Synthesis and biological activity of novel thiazolidinediones

Novel compounds having a dual pharmacophore were synthesised and evaluated for their insulin sensitiser and anti-inflammatory properties in different animal models.     

Thermal performance of “still on roof” system

This paper presents an analysis of periodic heat flux through a roof, on which a solar still has been placed. It is seen that on a typical hot day in Delhi, for high reflectivity of the bottom of the basin (on account of deposits or otherwise) the daily heat flux in the room gets reduced by 40% and the production of distilled water is 0.6 kg/m² day; the produced swings in the heat flux also get reduced in magnitude. For a typical cold day in Delhi, if a black dye is mixed with basin water the daily heat flux in the room increases by a factor of two and the yield of the distillate becomes 5.0 kg/m² day.     

Reliability Bounds for Decomposable Multi-component Systems

This paper obtains lower and upper bounds for decomposable multi-component complex systems. Some particular cases are discussed.     

Formation of M23C6 type carbides in heat-treated extra low carbon Mn-Si and Mn-Si-Nb high strength low alloy “mar” steels

Structural investigations in extra low carbon mar steels with nominal compositions A1 (4 Mn-1.0 Si), A2 (4 Mn-1.0 Si – 0.042 Nb), A3 (～ 5 Mn-1.5 Si), A4 (2.6 Mn-1.0 Si) and A5 (～ 5 Mn-2.5 Si) in the heat treated condition by X-ray diffraction technique (Debye-Scherrer method) for identifying strengthening mechanisms. Results on the formation of M₂₃C₆ type carbide either singly (in most cases) or in combination with austenite. Discussion pertaining to 1. identification of factors promoting the structural changes and, 2. their likely effect on mechanical properties.     

On profit considerations of a maintained system with minor repair

A maintained system is considered which can exit from the operable state to two states: failed and less productive. Profit equations are developed to study the system behaviour and a condition is derived under which the system can be profitably operated in a less productive state. A numerical example has been included to illustrate the results.     

Techniques based on genetic algorithms for large deflection analysis of beams

A couple of non-convex search strategies, based on the genetic algorithm, are suggested and numerically explored in the context of large-deflection analysis of planar, elastic beams. The first of these strategies is based on the stationarity of the energy functional in the equilibrium state and may therefore be considered weak. The second approach, on the other hand, attempts to directly solve the governing differential equation within an optimisation framework and such a solution may be thought of as strong. Several numerical illustrations and verifications with ‘exact’ solutions, if available, are provided For communication     

Surface-modified superparamagnetic nanoparticles for drug delivery: preparation, characterization, and cytotoxicity studies

Superparamagnetic iron oxide nanoparticles have been used for many years as magnetic resonance imaging (MRI) contrast agents or in drug delivery applications. In this study, a novel approach to prepare magnetic polymeric nanoparticles with magnetic core and polymeric shell using inverse microemulsion polymerization process is reported. Poly(ethyleneglycol) (PEG)-modified superparamagnetic iron oxide nanoparticles with specific shape and size have been prepared inside the aqueous cores of AOT/n-Hexane reverse micelles and characterized by various physicochemical means such as transmission electron microscopy (TEM), infrared spectroscopy, atomic force microscopy (AFM), vibrating sample magnetometry (VSM), and ultraviolet/visible spectroscopy. The inverse microemulsion polymerization of a polymerizable derivative of PEG and a cross-linking agent resulted in a stable hydrophilic polymeric shell of the nanoparticles. The results taken together from TEM and AFM studies showed that the particles are spherical in shape with core-shell structure. The average size of the PEG-modified nanoparticles was found to be around 40-50 nm with narrow size distribution. The magnetic measurement studies revealed the superparamagnetic behavior of the nanoparticles with saturation magnetization values between 45-50 electromagnetic units per gram. The cytotoxicity profile of the nanoparticles on human dermal fibroblasts as measured by standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that the particles are nontoxic and may be useful for various in vivo and in vitro biomedical applications.     

Synthesis of palladium nanoparticles using a continuous flow polymeric micro reactor

A continuous flow polymeric micro reactor, fabricated using a negative photo resist SU-8 on a 10 x 10 cm PEEK (polyetheretherketone) substrate by standard UV lithography, was utilized to synthesize palladium nanoparticles. The nanoparticles were characterized by Transmission Electron Microscopy, Selected Area Electron Diffraction and X-ray Diffraction. The Pd nanoparticles synthesized in the micro reactor were found to have a narrower size distribution when compared with those obtained by the conventional batch process.     

Cationic poly(lactide-co-glycolide) nanoparticles as efficient in vivo gene transfection agents

Poly(lactide-co-glycolide) (PLGA), a biocompatible and biodegradable polyester co-polymer of PLA and PGA, has been recognized for its ability to deliver genes. However, gene delivery by PLGA nanoparticles is limited by their negative charge and their poor transport through mucosal barriers. In this study, PLGA nanoparticles were surface modified with cationic chitosan in an effort to improve their gene delivery capability. PLGA nanoparticles were synthesized by emulsion-diffusion-evaporation technique using PVA-chitosan (PLGA1) or PVA-chitosan-PEG (PLGA2) blend as stabilizers. This method is reproducible and produces nanoparticles with hydrodynamic diameter <200 nm. The nanoparticles were characterized by zetasizer, photon correlation spectroscopy and atomic force microscopy. A549 epithelial cells were transfected in vitro with PLGA particles complexed with a reporter plasmid encoding green fluorescent protein. PLGA particles transferred EGFP gene, but were less efficient than the lipofectamine control. The nanoparticles were also tested for their ability to transport across the nasal mucosa in vivo in mice. The results show that both PLGA1 and PLGA2 facilitate gene delivery and expression in vivo with increased efficiency and without causing inflammation, as measured by IL-6. Together, these results indicate that chitosan-modified PLGA nanoparticles have greater potential as gene carriers.