Predicting Intentions from Motion: The Subject-Adversarial Adaptation Approach

International Journal of Computer Vision - This paper aims at investigating the action prediction problem from a pure kinematic perspective. Specifically, we address the problem of recognizing...     

Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase

pp120/HA4 is a hepatocyte membrane glycoprotein phosphorylated by the insulin receptor tyrosine kinase. In this study, we have investigated the role of pp120/HA4 in insulin action. Transfection of antisense pp120/HA4 cDNA in H35 hepatoma cells resulted in inhibition of pp120/HA4 expression and was associated with a 2-3-fold decrease in the rate of insulin internalization. Furthermore, insulin internalization in NIH 3T3 fibroblasts co-transfected with insulin receptors and pp120/HA4 was increased 2-fold compared with cells expressing insulin receptors alone. In contrast, no effect on internalization was observed in cells overexpressing a naturally occurring splice variant of pp120/HA4 that lacks the phosphorylation sites in the intracellular domain. Insulin internalization was also unaffected in cells expressing three site-directed mutants of pp120/HA4 in which the sites of phosphorylation by the insulin receptor kinase had been removed (Y488F, Y488F/Y513F, and S503A). Our data suggest that pp120/HA4 is part of a complex of proteins required for receptor-mediated internalization of insulin. It is possible that this function is regulated by insulin-induced phosphorylation of the intracellular domain of pp120/HA4.     

Meeting Interactivity Requirements in Mobile E-Witness: An Experimental Study

This paper describes the design and development of a session-layer load balancing mechanism and its deployment in a mobile surveillance system named Mobile E-Witness (MEW), which we have developed (Ghini et al., Multimedia Tools and Applications, 37(3), 293–318, 2008). The load balancing mechanism proposed in this paper allows MEW to effectively meet interactivity requirements and it is based on an “early retransmission” technique that exploits the overall bandwidth provided by a number of heterogeneous (broadband and metropolitan area) wireless adapters incorporated in MEW. This technique anticipates a suspected unavailability of the adapters in order to avoid the effects of network congestion and guarantee continuity of the communication service and support for multimedia services such as IP telephony. We have carried out an experimental evaluation of the MEW prototype in order to assess its effectiveness in meeting interactivity and responsiveness requirements. This paper summarizes our design and the principal results we have obtained from the evaluation mentioned above.     

Catalysts for the aromatization ofn-butane prepared by surface-contact transfer of gallium onto ZSM-5 zeolite particles

ZSM-5 zeolite particles into which 0.6 weight per cent or less of gallium oxide has been incorporated by surface-contact transfer, may exhibit very high activity in the aromatization ofn-butane. In some cases, the yield in aromatics is as high as that obtained with the hybrid catalyst wherein the cocatalyst is prepared by evaporation of a solution of gallium nitrate in Ludox colloidal silica.     

PIGA (N,N-Di-n-butyl-5-chloro-2-(4-chlorophenyl)indol-3-ylglyoxylamide), a new mitochondrial benzodiazepine-receptor ligand, induces apoptosis in C6 glioma cells

Mitochondrial benzodiazepine-receptor (mBzR) ligands constitute a heterogeneous class of compounds that show a pleiotropic spectrum of effects within the cells, including the modulation of apoptosis. In this paper, a novel synthetic 2-phenylindol-3-ylglyoxylamide derivative, N,N-di-n-butyl-5-chloro-2-(4-chlorophenyl)indol-3-ylglyoxylamide (PIGA), which shows high affinity and selectivity for the mBzR, is demonstrated to induce apoptosis in rat C6 glioma cells. PIGA was able to dissipate mitochondrial transmembrane potential (DeltaPsim) and to cause a significant cytosolic accumulation of cytochrome c. Moreover, typical features of apoptotic cell death, such as caspase-3 activation and DNA fragmentation, were also detected in PIGA-treated cells. Our data expand the knowledge on mBzR ligand-mediated apoptosis and suggest PIGA as a novel proapoptotic compound with therapeutic potential against glial tumours, in which apoptosis resistance has been reported to be involved in carcinogenesis.     

Design and performance evaluation of a waste-to-energy plant integrated with a combined cycle

In this paper, a waste-to-energy (WTE) system integrated with a gas fuelled combined cycle is considered. The plant is designed as a possible future option for thermal utilization of urban wastes in the northern part of the Turin Province, Italy. The plant should provide electricity (about 160 MW at maximum electric load) to the grid and heat to a district heating network (about 50 MW at maximum thermal load). This kind of plants is particularly interesting because of the high net electric efficiency (about 46%) that is possible to achieve, compared with the equivalent global efficiency of the separate plants (about +7% waste utilization efficiency with respect to conventional plants), and the complex design that is required.     

On the thermoeconomic approach to the diagnosis of energy system malfunctions: Part 2. Malfunction definitions and assessment

This paper goes further with the aim at demonstrating the capabilities of the thermoeconomic approach to the diagnosis of energy utility systems. This paper deals with a common vocabulary, definitions of concepts and mathematical principles, and above all, focuses on the concept of malfunction, starting from an engineering point of view and then shifting to a pure formalization as thermoeconomic parameters. Possible malfunctions of components of a combined cycle power plant are described in this part in terms of causes and effects. In addition, the main theoretical aspects of the thermoeconomic approach are shown. In particular the fuel impact formula, which constitutes the main thermoeconomic tool for quantifying the effects of degradation, is discussed.     

Biometric,nutritional and sensory changes in intensively farmed Murray cod (Maccullochella peelii peelii, Mitchell) following different purging times

A period of purging before harvesting is common practice in intensive aquaculture to eliminate any possible off flavours from the fish. The present study was conducted to evaluate the biometrical, nutritional and sensory changes in intensively farmed Murray cod (Maccullochella peelii peelii) after 0, 2 and 4 weeks of purging. After the main biometric parameters were recorded, fish were analysed for proximate, fatty acid composition and flavour volatile compounds. A consumer preference test (triangle test) was also conducted to identify sensorial differences that may affect the consumer acceptability of the product.