Stress analysis of a stepped rounded D‐ring with a ratio of H1/H2 = 3.0 under uniform squeeze rate and internal pressure by photoelastic experimental hybrid method

Stresses occurring in a stepped rounded D‐ring designed to have a ratio of H₁/H₂ = 3.0 and compressed to 20% squeeze and pressurized with internal pressures of 0 MPa, 0.98 MPa, 1.96 MPa, 3.92 MPa, 4.9 MPa and 5.89 MPa are analyzed using photoelastic experimental hybrid method. It was observed that when a pressure of 0 MPa and 20% compression are applied, the photoelastic isochromatic fringes of the stepped rounded D‐ring with a ratio of H₁/H₂ = 3.0 were almost symmetrical. However, as the applied internal pressure increased, the circular portion of the D‐ring moved over the step on the front side along the points 1_r–2_r towards the restraining wall of the front side of the groove. During the motion of the circular portion, the space between the restraining wall and the step on the front side was slowly filled; but unlike the D‐ring with a ratio of H₁/H₂ = 1.0 where complete filling occurred earlier before extrusion, complete filling of this space delayed until the portion of the D‐ring near the extrusion gap extruded. It was further noted that an internal pressure of up to 5.89 MPa was required to initiate extrusion in the D‐ring with a ratio of H₁/H₂ = 3.0.     

Improving linear processing systems via flexibility

In this paper we tried to improve a given stochastic processing line which is perfectly balanced. By introducing flexibility to a stochastic processing line, we can achieve the benefit of resource pooling. When we apply priority sequencing to the flexible processing line, we can attain an additional reduction in the mean throughput time. By using the heavy traffic approximation the ratio of improvement from flexibility is shown to be significant. We also considered the set-up time loss due to flexibility and derived the appropriate range in which flexibility outperforms set-up time loss. The result of this paper implies that we should consider the alternative of introducing flexibility to a processing system rather than trying to optimally allocate each segments of jobs and get a balanced processing line.     

The Discovery of Aurora Kinase Inhibitor by Multi-Docking-Based Virtual Screening

We report the discovery of aurora kinase inhibitor using the fragment-based virtual screening by multi-docking strategy. Among a number of fragments collected from eMololecules, we found four fragment molecules showing potent activity (>50% at 100 μM) against aurora kinase. Based on the explored fragment scaffold, we selected two compounds in our synthesized library and validated the biological activity against Aurora kinase.     

Effects of atomic size difference and heat of mixing parameters on the local structure of a model metallic glass system

Atomic size differences between constituting elements and the heat of mixing are key factors in designing a metallic glass system. In this study, the effects of atomic size differences and the heat of mixing on the glass-forming ability and the local structure of metallic glasses were studied via molecular dynamic simulations of an ideal system known as the Lennard-Jones embedded-atom method model. The atomic size difference and the heat of mixing of the system were varied by means of the Lennard-Jones parameters. The glass transition behavior was characterized based on the chemical short-range order and by a Voronoi analysis. Our simulations lead to optimized windows of atomic size differences and heat of mixing parameters for metallic glass-forming of the model system. Both a greater negative heat of mixing and a larger atomic size difference are necessary for the enhancement of the glass-forming ability.     

Spatial-temporal graph neural network for traffic forecasting: An overview and open research issues

Applied Intelligence - Traffic forecasting plays an important role of modern Intelligent Transportation Systems (ITS). With the recent rapid advancement in deep learning, graph neural networks...     

Mac-A-Mal: macOS malware analysis framework resistant to anti evasion techniques

Journal of Computer Virology and Hacking Techniques - With macOS increasing popularity, the number, and variety of macOS malware are rising as well. Yet, very few tools exist for dynamic analysis...     

Recent Progress of Fiber Shaped Lighting Devices for Smart Display Applications—A Fibertronic Perspective

Advances in material science and nanotechnology have fostered the miniaturization of devices. Over the past two decades, the form-factor of these devices has evolved from 3D rigid, volumetric devices through 2D film-based flexible electronics, finally to 1D fiber electronics (fibertronics). In this regard, fibertronic strategies toward wearable applications (e.g., electronic textiles (e-textiles)) have attracted considerable attention thanks to their capability to impart various functions into textiles with retaining textiles' intrinsic properties as well as imperceptible irritation by foreign matters. In recent years, extensive research has been carried out to develop various functional devices in the fiber form. Among various features, lighting and display features are the highly desirable functions in wearable electronics. This article discusses the recent progress of materials, architectural designs, and new fabrication technologies of fiber-shaped lighting devices and the current challenges corresponding to each device's operating mechanism. Moreover, opportunities and applications that the revolutionary convergence between the state-of-the-art fibertronic technology and age-long textile industry will bring in the future are also discussed.     

The APOA5-rs662799 Polymorphism Is a Determinant of Dyslipidemia in Vietnamese Primary School Children

Apolipoprotein A-V encoded by apolipoprotein 5 (APOA5) gene plays an important role in lipid metabolism, especially in the regulation of plasma triglycerol levels. The study aimed to evaluate the association of the APOA5-rs662799 polymorphism with dyslipidemia in Vietnamese children and the potential modification of obesity-related traits (body mass index, waist circumference, hip circumference, and waist-to-hip ratio) on this association. A case–control study was conducted with a total of 154 dyslipidemia cases and 389 controls at the age of 6 to 10 recruited at 31 primary schools in Hanoi city of Vietnam. Genotype for APOA5-rs662799 polymorphism was determined by the restriction fragment length polymorphism analysis. The association of APOA5-rs662799 polymorphism with dyslipidemia adjusting for age, sex, residence, and obesity-related traits was analyzed by binary logistic regression analysis. The results showed that in comparison with T/T and T/C carriers, the C/C carriers had a higher concentration of serum TAG in cases (p =0.049). Carriers of the C allele (C/C + T/C) had higher risk for developing dyslipidemia and hypertriglyceridemia than subjects with T/T genotype (odds ratio, OR = 1.7, p =0.0062 and OR = 1.6, p = 0.026, respectively). The association remained significant after adjusting for age, gender, residence, and obesity status (OR = 1.75, p = 0.006 and OR = 1.53, p = 0.049, respectively) or other obesity-related traits. The study suggested that the APOA5-rs662799 polymorphism may be a determinant of dyslipidemia and hypertriglyceridemia in Vietnamese children, independent of obesity-related traits.     

FeO0.7F1.3/C Nanocomposite as a High‐Capacity Cathode Material for Sodium‐Ion Batteries

Searching high capacity cathode materials is one of the most important fields of the research and development of sodium‐ion batteries (SIBs). Here, we report a FeO_0.7F_1.3/C nanocomposite synthesized via a solution process as a new cathode material for SIBs. This material exhibits a high initial discharge capacity of 496 mAh g^?1 in a sodium cell at 50 °C. From the 3^rd to 50^th cycle, the capacity fading is only 0.14% per cycle (from 388 mAh g^?1 at 3^rd the cycle to 360 mAh g^?1 at the 50^th cycle), demonstrating superior cyclability. A high energy density of 650 Wh kg^?1 is obtained at the material level. The reaction mechanism studies of FeO_0.7F_1.3/C with sodium show a hybridized mechanism of both intercalation and conversion reaction.