Consumption of solutions containing sodium chloride is enhanced in female oxytocin-deficient mice.

Intact and ovariectomized oxytocin (OT)-deficient (OT-/-) and wild-type (OT+/+) mice were tested for consumption of 0.5 M NaCl solution or tap water in a 2-bottle choice test. During 3 days of acclimation, voluntary ingestion of NaCl was equal between genotypes. After overnight fluid deprivation, intact OT-/- mice ingested 2 times more NaCl solution than OT+/+ mice in the 6th hr, but not the 1 st hr, after reintroduction of fluid. Ovariectomized mice consumed less than intact mice after overnight fluid deprivation. When a 0.2 M NaCl solution was administered for 6 days in ovariectomized mice, OT-/- mice voluntarily consumed greater amounts than OT+/+ mice. After overnight fluid deprivation, consumption by OT-/- mice was 3 times that of OT+/+ mice at 1 hr and 2-fold greater after 6 hr. Enhanced intake of NaCl-containing solutions in female OT-/- mice suggests that central OT may be an important inhibitor of sodium consumption. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Risk Factors for Course of Posttraumatic Stress Disorder Among Vietnam Veterans: A 14-Year Follow-Up of American Legionnaires.

Risk factors affecting the course of posttraumatic stress disorder (PTSD) are poorly understood. As part of a larger study on characterizing exposure to herbicides in Vietnam, the authors investigated this issue in a random sample of 1,377 American Legionnaires who had served in Southeast Asia during the Vietnam War and were followed over a 14-year period. High combat exposure, perceived negative community attitudes at homecoming, minority race, depression symptoms at Time 1, and more anger at Time 1 predicted a more chronic course. Community involvement at Time 1 was protective and associated with decreased risk at Time 2. Discomfort in disclosing Vietnam experiences was associated with an increased risk for developing PTSD but did not predict its course. Combat exposure predicted PTSD course more strongly than any other risk factor. Findings suggest recovery from PTSD is significantly influenced by perceived social support. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Good clinical laboratory practice (GCLP): the need for a hybrid of good laboratory practice and good clinical practice guidelines/standards for medical testing laboratories conducting clinical trials in developing countries.

There has been a significant increase in the number of clinical drug trials (particularly phase III) being conducted in developing countries for infectious diseases such as HIV, malaria, and tuberculosis. Laboratory results provided by medical testing laboratories in the region are critical to ensuring the safety of patients and the generation of good quality data. A number of well accepted Good Clinical Practice (GCP) and Good Laboratory Practice (GLP) guidelines govern the conduct of clinical trials internationally. Good Clinical Practice guidelines remain too vague with respect to sample analysis to ensure practical implementation in these laboratories. In their strictest sense, Good Laboratory Practice guidelines refer to the analysis of samples from non-clinical studies. A specific set of minimum standards or requirements for practical implementation of clinical trial requirements in medical testing laboratories in the developing world is urgently required.     

Infrastructure IP for configuration and test of boards and systems

Embedding infrastructure IP to optimize chip-level manufacturing test and debugging has recently become common practice. However, adopting the same approach for boards and systems requires a different family of infrastructure IP. This article introduces such a family and discusses how it can optimize manufacturing test and debugging, as well as support configurability, especially in today's reconfigurable products.     

Experimental and analytical studies of innovative prestressed concrete box-girder bridges

This paper presents experimental and analytical results of four scaled prestressed concrete box-girder bridges with corrugated steel webs. The location of prestressing strands at both ends of the specimens and the thickness of end diaphragms are the two major parameters. Based on the experimental results of all four specimens, their seismic behavior is critically examined, including hysteretic loops, ductility factor, dissipated energy, and failure mode, etc. It was found that both the thickness of end diaphragms and the location of prestressing strands at both ends of the specimens are insignificant when the specimens failed at the mid-span due to concrete crushing, and the proposed analytical model can be used to predict the load-displacement relationship of such bridges.     

Convergence of simultaneous perturbation stochastic approximation for nondifferentiable optimization

We consider simultaneous perturbation stochastic approximation for function minimization. The standard assumption for convergence is that the function be three times differentiable, although weaker assumptions have been used for special cases. However, all work that we are aware of at least requires differentiability. We relax the differentiability requirement and prove convergence using convex analysis.     

Recent Development of Cognitive and Neuropsychological Assessment in Asian Countries.

There is a growing trend of research in neuropsychological assessment in Asia: The mean number of published studies increased from 1.8 in the 1980s to 16.0 in 2 recent years. About 40% of the studies reviewed concerned test development or adaptation, with the latter greatly outnumbering the former. To facilitate the test selection for clinical use, 36 clinical measures were evaluated based on some statistical criteria. The results showed that only 8 neuropsychological tests (5 Chinese. 2 Korean, and 1 Japanese) met the criteria. Given that Asian and Western populations differ on certain cognitive processes, future development of neuropsychological assessment measures in Asia should move from the adaptation of Western tests toward the construction of original tests with better ecological validity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

广泛应用机器人技术是提高连铸安全性的重要步骤

1前言及历史背景 为避免钢水造成燃烧或破碎引起对人体的可能伤害,必须对连铸平台的平面布置进行分析.     

Prediction of Undrained Sinkhole Collapse

Sinkholes are surface depressions or shafts resulting from the collapse of a submerged cavity in soil. The cavities that lead to sinkholes form as a result of underlying geology in limestone areas, or as a result of human activity such as mining or leakage from a sewer. The formation of sinkholes is often sudden and can lead to extensive damage and loss of life, especially in urban areas. Much of the literature on the subject of sinkhole formation is empirical in nature, often being associated with specific locations. This paper presents the results of a study, using numerical modeling, of the undrained stability of the submerged cavities that lead to sinkhole formation. Finite-element limit analysis techniques (using programs developed at the University of Newcastle) are used to obtain upper and lower bound values of a suitable load parameter, which bracket the exact solution. The results are compared to analytical solutions, both from literature and derived independently.     

Competitiveness of Inexperienced and Experienced Contractors in Bidding

This paper tests the assertion that experienced contractors are more competitive than inexperienced contractors by measuring the effect of experience on bidding competitiveness for building contracts procured by a regular client. Contractors are grouped into experienced and inexperienced contractors, and two levels of contractors’ experience are identified: (1) bidding experience only and (2) bidding plus construction experience. Results of two-sample t tests show that experienced contractors are more competitive than inexperienced contractors. Contractors’ competitiveness in respect of school contracts and other contracts are further compared in evaluating the relationship between the project type and experience effect. Experienced contractors are, on average, more competitive in competing for school contracts. It emerges that the factor of project type familiarity amplifies the experience effect. A comparison of experienced contractors’ competitiveness in bidding for (1) new building works and (2) alteration and extension works shows that the effect of experience would be more significant when contract works packages are highly standardized.