小桥涵盖板施工中常见质量问题成因与防治

结合施工实践，介绍了小桥涵盖板：沲工中出现的质量问题，分析了产生问题的主要原因，从具体施工方法的角度．提出防治这些问题的措施，指出只有施工、试验、质检、监理人员各方主体各负其责，分头把关，才能减少质量通病的发生。     

城市化背景下城市规划与产业规划的互动关系

以江苏省近20年来的城市化进程为背景,通过城市规划与产业规划互动发展的研究,以此来研究城市规划与产业规划是否存在先导性与推动性、相容性与相背性以及协调性和互动性关系,为确保城市化背景下的城市和产业良性发展提供理论依据。     

中关村信息产业专门化街区的建构

通过对中关村“电子一条街”城市空间和景观演化的分析，初步讨论了信息产业专门化街区形成的原因。通过对信息产业专门化街区构成要素以及要素间邻近度的分析，总结了信息产业专门化街区的发展趋势，并在此基础上提出了“电子街区”的规划结构图。     

上海市安亭新镇人工水体近自然型水景建设途径与技术

以上海安亭新镇人工水体的调查监测结果为依据,探讨了人工水体近自然型水质调控及城市水景观建设规划、实施和管护技术体系,包括水系近自然生态护岸工程、补给水截污净化工程、综合防治水体污染、富营养化工程和水体景观绿化工程4个方面,以期将水中污染物质迁移出水体,起到防治水体污染和富营养化的作用。     

Fully automated single-molecule force spectroscopy for screening applications

With the introduction of single-molecule force spectroscopy (SMFS) it has become possible to directly access the interactions of various molecular systems. A bottleneck in conventional SMFS is collecting the large amount of data required for statistically meaningful analysis. Currently, atomic force microscopy (AFM)-based SMFS requires the user to tediously 'fish' for single molecules. In addition, most experimental and environmental conditions must be manually adjusted. Here, we developed a fully automated single-molecule force spectroscope. The instrument is able to perform SMFS while monitoring and regulating experimental conditions such as buffer composition and temperature. Cantilever alignment and calibration can also be automatically performed during experiments. This, combined with in-line data analysis, enables the instrument, once set up, to perform complete SMFS experiments autonomously.     

Overview of active personal dosemeters for individual monitoring in the European Union

In 2001, the European Radiation Dosimetry Group, EURADOS, started a working group on 'Harmonisation of Individual Monitoring in Europe and the Dissemination of Information on New Techniques in this Field'. Within this group, one of the projects consisted of analysing the status of active personal dosemeters (APDs) in Europe. This paper reviews the regulatory requirements for APDs in 15 EU member states and summarises the main characteristics of commercial and new developments in this field. In particular, it focuses on the comparison of APD performance and standard passive dosimetry systems. Based on this information, an evaluation is initiated to establish why several countries are reluctant to accept APDs for dose records.     

Molecular parameters of type IV alpha-internexin and type IV-type III alpha-internexin-vimentin copolymer intermediate filaments

During neuronal development, a dynamic replacement mechanism occurs in which the type VI nestin and type III vimentin intermediate filament proteins are replaced by a series of type IV proteins beginning with alpha-internexin. We have explored molecular details of how the type III to type IV replacement process may occur. First, we have demonstrated by cross-linking experiments that bacterially expressed forms of alpha-internexin and vimentin form heterodimer molecules in vitro that assemble into copolymer intermediate filaments. We show using a urea disassembly assay that alpha-internexin molecules are likely to be more stable than those of vimentin. Second, by analyses of the induced cross-links, we have determined the axial lengths of alpha-internexin homodimer and alpha-internexin-vimentin heterodimer molecules and their modes of alignments in filaments. We report that these dimensions are the same as those reported earlier for vimentin homopolymer molecules and, by implication, are also the same for the other neuronal type IV proteins. These data suggest that during neuronal development, alpha-internexin molecules are readily assimilated onto the pre-existing vimentin cytoskeletal intermediate filament network because the axial lengths and axial alignments of their molecules are the same. Furthermore, the dynamic replacement process may be driven by a positive equilibrium due to the increased stability of the alpha-internexin network.