纳米聚N-异丙基丙烯酰胺微凝胶的光引发聚合

选择具有温敏性的高分子单体N－异丙基丙烯酰胺（N－isopropylacrylamide，NIPAM）为主单体，N，N′－亚甲基双丙烯酰胺（methylenebisacrylamide，MBA）为交联剂，运用光引发无皂乳液聚合的方法合成出粒径小于100nm的高分子微凝胶，并研究了在改变体系组成和条件时微凝胶粒径的变化。结果显示，在乳化剂临界胶束浓度以下，随着乳化剂浓度的提高，微凝胶粒子的粒径不断关小且趋向稳定；相比于热引发，产生的微凝胶具有较高的单分散性而且粒径较小。     

大环分子低维导体

本文综述了大环分子面－面堆积结构的准一维导体的结构、性质、导电机理、合成方法及研究进展。     

Methods to compare dissolution profiles and a rationale for wide dissolution specifications for metoprolol tartrate tablets

The objectives of this work were to apply several profile comparison approaches to dissolution data of four different but bioequivalent metoprolol tartrate tablet formulations to (1) identify the advantages and disadvantages of each approach, (2) quantify the metric for comparing dissolution profiles of each method, (3) determine metric limits that are consistent with the observed bioequivalence, and (4) rationalize the observed metric limits with respect to the role of dissolution in overall metoprolol absorption. Dissolution was performed by the USP monograph method on four formulations of metoprolol tartrate tablets (Lopressor plus fast, medium, and slow dissolving test formulations). Three general approaches to compare dissolution profiles were examined; they were ANOVA-based, model-independent, and model-dependent approaches. It is concluded that model-independent approaches and several model-dependent approaches yielded numerical results that can serve as objective and quantitative metrics for comparing entire dissolution profiles of the four metoprolol tartrate formulations. However, these methods presented complications. Some metrics were dependent on the length of the dissolution profile and the sampling scheme. Results from the pairwise procedures also depended on the pairing assignment of individual profiles. In spite of complications, these methods suggested wide dissolution specification limits. Wide dissolution specifications were rationalized through an analysis of in vitro-in vivo relationships, which indicated metoprolol dissolution from these formulations was not the rate-limiting step; hence, a range of dissolution profiles can be expected to yield equivalent plasma profiles.     

海上靶场角度量录取系统的研制

本文详细叙述了海上靶场角度量录取糸统的组成、测试原理及其功能设计，简要介绍了该系统在靶扬的应用情况．     

Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage

Amplification of genes involved in signal transduction and cell cycle control occurs in a significant fraction of human cancers. Loss of p53 function has been proposed to enable cells with gene amplification to arise spontaneously during growth in vitro. However, this conclusion derives from studies employing the UMP synthesis inhibitor N-phosphonacetyl-L-aspartate (PALA), which, in addition to selecting for cells containing extra copies of the CAD locus, enables p53-deficient cells to enter S phase and acquire the DNA breaks that initiate the amplification process. Thus, it has not been possible to determine if gene amplification occurs spontaneously or results from the inductive effects of the selective agent. The studies reported here assess whether p53 deficiency leads to spontaneous genetic instability by comparing cell cycle responses and amplification frequencies of the human fibrosarcoma cell line HT1080 when treated with PALA or with methotrexate, an antifolate that, under the conditions used, should not generate DNA breaks. p53-deficient HT1080 cells generated PALA-resistant variants containing amplified CAD genes at a frequency of >10(-5). By contrast, methotrexate selection did not result in resistant cells at a detectable frequency (<10(-9)). However, growth of HT1080 cells under conditions that induced DNA breakage prior to selection generated methotrexate-resistant clones containing amplified dihydrofolate reductase sequences at a high frequency. These data demonstrate that, under standard growth conditions, p53 loss is not sufficient to enable cells to produce the DNA breaks that initiate amplification. We propose that p53-deficient cells must proceed through S phase under conditions that induce DNA breakage for genetic instability to occur.     

Ice/metal interfaces: fracture energy and fractography

Results are presented of the fracture tests of ice/metal interfaces in an attempt to utilize fracture mechanics to characterize the failure of ice/solid adhesion. The four-point bending delamination specimen was used to measure the fracture energy of ice/aluminium and ice/steel joints at — 15 °C. The interfacial fracture energy was found to be dependent on ice type and formation procedure of the ice/metal composites. Crack growth was in a manner of asymmetrical bursting, and both cohesive and adhesive failure mechanisms were observed. Although the fracture of ice/metal interfaces was brittle in nature, the evidence of dislocation slip in ice crystals, as revealed by etching and replicating, suggests that microplastic deformations occur in the ice component.     

河道维护费征收中需注意的几个问题

依法征收河道工程维护费,是水行政主管部门的一项重要职能,是强化水利依法管理的重要手段和筹措水利建设资金的重要途径。随着依法行政进程的不断推进,被征管单位依法维权的意识不断增强。根据《行政诉讼法》的规定,人民法院审查行政案件,对具体行政行为是否合法进行审查。根据《行政复议法》的规定,复议机关审查复议案件,对具体行政行为是否合法     

清代皇家园林规划设计控制的量化研究——以圆明三园、清漪园为例

本文通过量化分析探索了清代皇家园林规划设计的控制规律及相关理论。     

液态混合有机标准物质研究

本研究采用重量法配制有机液态混合标样 ,并对配制方法、混合标样的均匀性、稳定性及影响不确定度的因素进行了研究 ,并用气相色谱法进行了比对分析。经稳定性监测 ,稳定度大于等于一年 ,不确定度小于± 2 %。