铂与氢、水和苯分子相互作用的量子化学研究

采用量子化学程序Gaussian98(A.9)从头算的B3LYP方法，全优化计算铂对氢、水和苯的化学吸附作用，得到了3种相关络合物PtX、PtXX和Ptxxx(X=H，H2O或C6H6)的平衡几何构型和电子结构信息，并探讨了这些络合物的成键性质，以及苯环与铂原子之间的分子轨道作用性质。结果表明，苯环与铂原子之间有很强的成键作用，并随着游离氢原子和水分子的参与，作用强度有很大变化。苯分子吸附在金属铂上，它的芳香性得到不同程度的降低，苯环被活化，苯环与铂原子之间形成η^2型π键络合物；水参与作用后，苯环与铂原子之间形成σ络合物；氢和水同时参与作用后，苯环与铂原子之间仅有很弱的π轨道作用。     

EMS1 gene expression in primary breast cancer: relationship to cyclin D1 and oestrogen receptor expression and patient survival

The EMS1 and CCND1 genes at chromosome 11q13 are amplified in about 15% of primary breast cancers but appear to confer different phenotypes in ER positive and ER negative tumours. Since there are no published data on EMS1 expression in large series of breast cancers we examined the relationship of EMS1 expression with EMS1 gene copy number and expression of mRNAs for cyclin D1 and ER. In a subset of 129 patients, where matched tumour RNA and DNA was available, EMS1 mRNA overexpression was associated predominantly with gene amplification (P = 0.0061), whereas cyclin D1 mRNA overexpression was not (P = 0.3142). In a more extensive series of 351 breast cancers, there was no correlation between cyclin D1 and EMS1 expression in the EMS1 and cyclin D1 overexpressors (P = 0.3503). Although an association between EMS1 mRNA expression and ER positivity was evident (P = 0.0232), when the samples were divided into quartiles of EMS1 or cyclin D1 mRNA expression, the increase in the proportion of ER positive tumours in the ascending EMS1 mRNA quartiles was not statistically significant (P = 0.0951). In marked contrast there was a significant stepwise increase in ER positivity in ascending quartiles of cyclin D1 mRNA (P = 0.030). A potential explanation for this difference was provided by the observation that in ER positive breast cancer cells oestradiol treatment resulted in increased cyclin D1 gene expression but was without effect on EMS1. The relationship between EMS1 expression and clinical outcome was examined in a subset of 234 patients with median follow-up of 74 months. High EMS1 expression was associated with age > 50 years (P = 0.0001), postmenopausal status (P = 0.0008), lymph node negativity (P = 0.019) and an apparent trend for worse prognosis in the ER negative subgroup. These data demonstrate that overexpression of EMS1 mRNA is largely due to EMS1 gene amplification, is independent of cyclin D1 and ER expression and, in contrast to cyclin D1, is not regulated by oestrogen. Independent overexpression of these genes may confer different phenotypes and disease outcomes in breast cancer as has been inferred from recent studies of EMS1 and CCND1 gene amplification.     

Designing the MPC105 PCI bridge/memory controller

The MPC105 peripheral component interconnection bridge/memory controller provides a platform-specification-compliant bridge between Power PC microprocessors and the PCI bus. With it, designers can create systems using peripherals already designed for a variety of standard PC interfaces. This bridge chip also integrates a secondary cache controller and high-performance memory controller that supports DRAM or synchronous DRAM and ROM or flash ROM     

新型合金代铬刷镀层的组织及强化机理的研究

采用Ｘ射线衍射仪，透射电镜和扫描隧道显微镜等手段对新型代铬镀层（Ｎｉ－Ｆｅ－Ｗ－Ｐ－Ｓ）相结构及组织进行了研究，并初步探讨了镀层的强化机理。研究表明，Ｎｉ－Ｆｅ－Ｗ－Ｐ－Ｓ合金镀层的组织是由含Ｆｅ、Ｗ、Ｐ、Ｓ的镍基固溶体和在其上弥散分布的金属间化合物Ｎｉ_３Ｆｅ所组成，镍基固溶体处于非晶和微晶的混合状态，合金镀层的镀态硬度为ＨＶ７００～７５０，在３００℃退火时。硬度达到最大值ＨＶ９００～９５０，其强化机理主要是微晶的晶界强化和Ｎｉ_３Ｆｅ的弥散强化。     

多路红外防盗报警器

介绍一种利用热释红外线传感器探头作为探测器的多路防盗报警器.该报警器能够自动完成交直流供电转换,具有灵敏度高、电压适用范围宽、准确可靠等特点,并配有多种声光报警方式.给出了该报警器的基本原理和方框图。     

Role of Epstein-Barr virus in fine-needle aspirates of metastatic neck nodes in the diagnosis of nasopharyngeal carcinoma

The crystal structure of the peptide Boc-Phe-Val-OMe determined by X-ray diffraction methods is reported in this paper. The crystals grown from aqueous methanol are orthorhombic, space group P2(1)2(1)2(1),a = 11.843(2), b = 21.493(4), c = 26.676(4) A3 and V = 6790 A3. Data were collected on a CAD4 diffractometer using MoK alpha radiation (lambda = 0.7107 A) up to Bragg angle theta = 26 degrees. The structure was solved by direct methods and refined by a least-squares procedure to an R value of 6.8% for 3288 observed reflections. There are three crystal-lographically independent peptide molecules in the asymmetric unit. All the three molecules exhibit extended conformation. The sidechain of the Val2 residue shows two different conformations. The conformation of the peptide Boc-Phe-Val-OMe is compared with the conformation of Ac-delta Phe-Val-OH. It is observed that while Boc-Phe-Val-OMe exhibits an extended conformation, Ac-delta Phe-Val-OH shows a folded conformation. The results of this comparison highlight the conformation constraining property of the delta Phe residue. Interestingly, even though Boc-Phe-Val-OMe and Ac-delta Phe-Val-OH are conformationally different, they exhibit similar packing patterns in the solid state.     

A formal model for the interoperability of service clouds

Large-scale service-oriented computing is based on the idea that services from various servers are combined into one distributed application. Referring to a collection of services on one server as a ??service cloud??, the problem investigated in this paper is to define formal high-level specifications of such distributed applications and to enable the location of suitable services for them. Based on the language-independent model of Abstract State Services (AS²s), which serves as a universal integrated model for data and software as services, we extend AS²s by high-level action schemes called ??plots?? as a means to specify permitted sequences of service operations. On these grounds, we develop a model for service mediators, that is, specifications of composed services in which service slots have to be filled by actual services, and investigate matching conditions for slots of mediators and services. For a services to match a slot in a mediator, a (generalised) projection of the mediator must comply with the plot of the service. Furthermore, the service must be semantically adequate, which requires the use of a service ontology.     

山东智慧旅游研究

文章对山东旅游行业的发展现状进行了调查、归纳和总结,提出了山东智慧旅游发展的思路和重点,并从山东旅游行业四个主要应用群体（旅游管理部门、景区、酒店和旅行社）出发,提出了山东智慧旅游解决方案。     

带以太网接口的GSM无线数据传输系统设计与实现

较为全面地介绍了当前远程监控系统的应用现状,并对现有传输系统的特点进行了分析和研究。在此基础上,提出了适用于远程监控系统的、基于GSM的无线数据传输系统的总体架构及设计方案,详细介绍了带有以太网接口的、基于GSM的无线数据传输系统的硬件电路与软件设计与实现方法。该系统适用于各种远程监测监控系统,对提高远程监控的数据传输效率和降低监控系统的运营成本具有重要意义。