HSPA4 Is a Biomarker of Placenta Accreta and Enhances the Angiogenesis Ability of Vessel Endothelial Cells

Placenta accreta spectrum (PAS) accounts for 7% of maternal mortality and is associated with intraoperative and postoperative morbidity caused by massive blood loss, infection, and adjacent organ damage. The aims of this study were to identify the protein biomarkers of PAS and to further explore their pathogenetic roles in PAS. For this purpose, we collected five placentas from pregnant subjects with PAS complications and another five placentas from normal pregnancy (NP) cases. Then, we enriched protein samples by specifically isolating the trophoblast villous, deeply invading into the uterine muscle layer in the PAS patients. Next, fluorescence-based two-dimensional difference gel electrophoresis (2D-DIGE) and MALDI-TOF/MS were used to identify the proteins differentially abundant between PAS and NP placenta tissues. As a result, nineteen spots were determined as differentially abundant proteins, ten and nine of which were more abundant in PAS and NP placenta tissues, respectively. Then, specific validation with western blot assay and immunohisto/cytochemistry (IHC) assay confirmed that heat shock 70 kDa protein 4 (HSPA4) and chorionic somatomammotropin hormone (CSH) were PAS protein biomarkers. Further tube formation assays demonstrated that HSPA4 promoted the in vitro angiogenesis ability of vessel endothelial cells, which is consistent with the in vivo scenario of PAS complications. In this study, we not only identified PAS protein biomarkers but also connected the promoted angiogenesis with placenta invasion, investigating the pathogenetic mechanism of PAS.     

用核糖体工程技术二次开发海洋微生物菌株资源的研究

经对无活性的海洋来源放线菌B3054进行链霉素抗性筛选,获得了一株具有抗肿瘤活性的链霉素抗性突变株SY-1.从该突变株的发酵物中分离得到了4个活性化合物,其中1个为新天然产物.对该菌株突变前后的rpsL基因(编码核糖体蛋白S12)进行分析未发现发生突变,提示突变位点可能在核糖体的另外亚基上.实验结果表明,核糖体工程技术可用于无活性菌株资源的二次开发利用.     

摩擦改进剂对改善燃油经济性的影响研究

采用四球机试验,考察了钼胺化合物、二烷基二硫代氨基甲酸钼、无灰型摩擦改进剂与摩擦因数的关系以及它们之间的复配作用。结果表明：摩擦改进剂（FM）降低摩擦因数的效果与其化学结构有关;加入量提高,摩擦因数的改善效果明显;不同化学结构的摩擦改进剂复配使用,可以减低整个温度区的摩擦因数。     

Terahertz Direct Modulation Techniques for High-speed Communication Systems

Terahertz communication technology can provide abundant frequency resources,strong confidentiality,antijamming capability,communication tracking capability and ...     

拔染剂的应用性能研究

综合分析了三种拔染剂在拔染浆中的稳定性、吸湿性和渗透性等应用性能，并得出一些重要结论。     

添加ZrO2对铜基摩擦材料摩擦磨损性能的影响

采用粉末冶金方法制备了高速列车用铜基摩擦材料,研究了添加ZrO2的量对材料的摩擦因数、磨损量的影响规律。结果表明:在添加ZrO2的材料中,含5%(质量分数,下同)ZrO2的材料摩擦因数较高,磨损量也较大;添加8%ZrO2的材料在高速下的摩擦因数较高,磨损率较小且变化平稳。材料的磨损在较低的速度下以粘着磨损为主;随着速度的上升,磨损也逐渐变成以剥层脱落和氧化磨损的混合机制为主。     

全自动剥多芯线一体机控制系统设计

针对目前国内多芯线材内芯加工困难和生产效率低下问题,介绍了一种全自动剥多芯线控制系统.以C8051F340单片机为控制核心,采用主从式MCU结构,液晶HJ12864ZW为人机界面;主MCU设定和显示多芯线加工的相关参数及报警输出,从MCU通过串口接收主MCU的信息控制4台步进电机和捋线装置实现多芯线材的加工.通过实验表明,该控制系统可实现多芯线材裁剪、剥皮、剥内芯一体全自动加工功能,具有良好的应用前景.     

基于Rough集方法的RS-MAXNET网络分类器模型

Rough集（RS）理论中如何补偿或拓展Rs约简的局部决策规则使之更加接近全局规则是一个重要的议题。本文提出RS与MAXNET网络结合拓展建立盼MAXNET全局网络分类器模型。基于上述模型进行的脱机手写模式识别算法说明了其有效性。     

[(t-BuCP)_2NdMe]_2/添加剂体系催化丙烯腈聚合

本文研究了［（t－BuCP）2NdMe］2／添加剂体系对丙烯腈的催化聚合,并考察了添加剂比例、温度、催化剂用量、单体浓度及溶剂对聚合活性的影响．