7 T renal MRI: challenges and promises

The progression to 7 Tesla (7 T) magnetic resonance imaging (MRI) yields promises of substantial increase in signal-to-noise (SNR) ratio. This increase can be traded off to increase image spatial resolution or to decrease acquisition time. However, renal 7 T MRI remains challenging due to inhomogeneity of the radiofrequency field and due to specific absorption rate (SAR) constraints. A number of studies has been published in the field of renal 7 T imaging. While the focus initially was on anatomic imaging and renal MR angiography, later studies have explored renal functional imaging. Although anatomic imaging remains somewhat limited by inhomogeneous excitation and SAR constraints, functional imaging results are promising. The increased SNR at 7 T has been particularly advantageous for blood oxygen level-dependent and arterial spin labelling MRI, as well as sodium MR imaging, thanks to changes in field-strength-dependent magnetic properties. Here, we provide an overview of the currently available literature on renal 7 T MRI. In addition, we provide a brief overview of challenges and opportunities in renal 7 T MR imaging.     

Generation-Recombination Noise: The Fundamental Sensitivity Limit for Kinetic Inductance Detectors

We present measurements of quasiparticle generation-recombination noise in aluminium Microwave Kinetic Inductance Detectors, the fundamental noise source for these detectors. Both the quasiparticle lifetime and the number of quasiparticles can be determined from the noise spectra. The number of quasiparticles saturates to 10?μm^?3 at temperatures below 160?mK, which is shown to limit the quasiparticle lifetime to 4?ms. These numbers lead to a generation-recombination noise limited noise equivalent power (NEP) of 1.5×10^?19?W/Hz^1/2. Since NEP∝N _qp , lowering the number of remnant quasiparticles will be crucial to improve the sensitivity of these detectors. We show that the readout power now limits the number of quasiparticles and thereby the sensitivity.     

Ultra Low Background Cryogenic Test Facility for Far-Infrared Radiation Detectors

The next generation of far infrared radiation detectors is aimed to reach photon noise limited performance in space based observatories such as SPICA and BLISS. These detectors operate at loading powers of the astronomical signal of a few Attowatt (10^?18 W) or less, corresponding to a sensitivity expressed in noise equivalent power as low as $\mathrm{NEP} = 2\times10^{-20}\ \mbox{W}/\sqrt{\mathrm{Hz}}$ . We have developed a cryogenic test setup for microwave Kinetic Inductance Detectors (MKIDs) that aims to reach these ultra-low background levels. Stray light is stopped by using a box in a box design with a sample holder inside another closed box. Microwave signals for the MKID readout enters the outer box through custom made coax cable filters. The stray light loading per pixel is estimated to be less than 60×10^?18 W during nominal operation, a number limited by the intrinsic sensitivity of the MKIDs used to validate the system.     

The Superconducting Ferromagnet UCoGe

The correlated metal UCoGe is a weak itinerant ferromagnet with a Curie temperature T _C=3 K and a superconductor with a transition temperature T _s=0.6 K. We review its basic thermal, magnetic—on the macro and microscopic scale—and transport properties, as well as the response to high pressure. The data unambiguously show that superconductivity and ferromagnetism coexist below T _s=0.6 K and are carried by the same 5f electrons. We present evidence that UCoGe is a p-wave superconductor and argue that superconductivity is mediated by critical ferromagnetic spin fluctuations.     

Au-Sn SLID Bonding: A Reliable HT Interconnect and Die Attach Technology

Au-Sn solid–liquid interdiffusion (SLID) bonding is an established reliable high temperature (HT) die attach and interconnect technology. This article presents the life cycle of an optimized HT Au-Sn SLID bond, from fabrication, via thermal treatment, to mechanical rupture. The layered structure of a strong and uniform virgin bond was identified by X-ray diffraction to be Au/ζ (Au_0.85Sn_0.15)/Au. During HT exposure, it was transformed to Au/β (Au_1.8Sn_0.2)/Au. After HT exposure, the die shear strength was reduced by 50 pct, from 14 Pa to 70 MPa, which is still remarkably high. Fractographic studies revealed a change in fracture mode; it was changed from a combination of adhesive Au/Ni and cohesive SiC fracture to a cohesive β-phase fracture. Design rules for high quality Au-Sn SLID bonds are given.     

Multi-disciplinary design optimization of a combustor

A technique for design optimization of a combustor is presented. This technique entails the use of computational fluid dynamics (CFD) and mathematical optimization to minimize the combustor exit temperature profile. The empirical and semi-empirical correlations commonly used for optimizing combustor exit temperature profile do not guarantee optimum. As an experimental approach is time consuming and costly, use is made of numerical techniques. However, using CFD without mathematical optimization on a trial and error basis does not guarantee optimal solutions. A better approach, which is often viewed as too expensive, is a combination of the two approaches, thus incorporating the influence of the variables automatically. In this study the combustor exit temperature profile is optimized. The optimum (uniform) combustor exit temperature profile mainly depends on the geometric parameters. Combustor parameters have been used as optimization variables. The combustor investigated is an experimental liquid-fuelled atmospheric combustor with a turbulent diffusion flame. The CFD simulations use the Fluent code with a standard k–? model. The optimization is carried out using the Dynamic-Q algorithm, which is specifically designed to handle constrained problems where the objective and constraint functions are expensive to evaluate. The optimization leads to a more uniform combustor exit temperature profile compared with the original.     

17.9% Metal‐wrap‐through mc‐Si cells resulting in module efficiency of 17.0%

We obtained 17.9% cell efficiency on thin and large mc‐Si REC wafers using ECN's metal‐wrap‐through (MWT) concept. Optimization of several cell processing steps led to an increase of more than 2% absolute in cell efficiency. With these cells 36‐cell modules were manufactured at 100% yield in our industry scale module pilot line. The highest module efficiency obtained (as independently confirmed by JRC‐ESTI) was 17%. In this module the average cell efficiency was 17.8%; this shows a small difference between cell and module efficiency. Copyright © 2011 John Wiley & Sons, Ltd.     

Polymer nanosieve membranes for CO2-capture applications

Microporous organic polymers (MOPs) are of potential significance for gas storage, gas separation and low-dielectric applications. Among many approaches for obtaining such materials, solution-processable MOPs derived from rigid and contorted macromolecular structures are promising because of their excellent mass transport and mass exchange capability. Here we show a class of amorphous MOP, prepared by [2+3] cycloaddition modification of a polymer containing an aromatic nitrile group with an azide compound, showing super-permeable characteristics and outstanding CO(2) separation performance, even under polymer plasticization conditions such as CO(2)/light gas mixtures. This unprecedented result arises from the introduction of tetrazole groups into highly microporous polymeric frameworks, leading to more favourable CO(2) sorption with superior affinity in gas mixtures, and selective CO(2) transport by presorbed CO(2) molecules that limit access by other light gas molecules. This strategy provides a direction in the design of MOP membrane materials for economic CO(2) capture processes.     

Prevalence of gastrointestinal disorders recorded at postmortem inspection in white veal calves and associated risk factors

The study aimed at assessing the prevalence of poor rumen development, presence of rumen plaques, rumen papillae hyperkeratinization, and abomasal lesions in veal calves and to investigate risk factors for their occurrence at the farm level. Within a wide cross-sectional study, a sample of 170 veal farms representative of the European veal meat production systems was considered in the 3 major producing countries (99 in the Netherlands, 47 in France, and 24 in Italy). An average of 59 ± 10 (SD) rumens and abomasa belonging to calves from a single batch per farm were inspected at the abattoir by trained observers to assess the incidence of these gastrointestinal disorders. Potential risk factors for their occurrence related to farm management, housing, and to the feeding plan were obtained by a questionnaire submitted to the stockperson. Prevalence of poor rumen development (almost no papillae present), rumen plaques, and hyperkeratinization were 60.4, 31.4, and 6.1% of rumens, respectively, whereas abomasal lesions in the pyloric area were recorded in 74.1% of abomasa. Independent variables related to the feeding system confirmed to be the main risk factors for the occurrence of gastrointestinal disorders in veal calves. However, additional risk sources for each given problem were identified among housing and management variables. The provision of a low amount of solid feed (≤50 kg of dry matter/head per cycle) was a relevant risk for rumen underdevelopment. Rumen wall alterations (plaques and hyperkeratinization) and abomasal lesions were instead associated with the administration of large quantities of solids (151-300 kg of dry matter/head per cycle) in calves receiving milk replacer during the entire fattening cycle. Among the types of solid feed, cereal grain acted as a preventive measure for low rumen development, whereas it was a risk factor for the occurrence of rumen plaques, papillae hyperkeratinization, and abomasal lesions. Some housing and management options adopted to improve veal calf welfare (i.e., higher space allowance and use of heating) were associated with lower risk for gastrointestinal disorders.