论西部历史文化名城的保护与建设

本文首先提出了历史文化名城的保护作用和保护目的,确定历史文化名城的保护范畴及保护方式,阐述了历史文化名城建设中所面临的实际问题与解决对策.在此基础上,再引伸出西部历史文化名城的特点与风貌,重点对平遥、西安等城市作了较为详细的介绍和分析。文章最后提出了对西部历史文化名城的建设与发展的一些意见和看法.     

Estimating Displacement of Periodic Motion With Inertial Sensors

Inertial sensors, like accelerometers and gyroscopes, are rarely used by themselves to measure displacement. Accuracy of inertial sensors is greatly handicapped by the notorious integration drift, which arises due to numerical integration of the sensors zero bias error. A solution is proposed in this paper to provide drift free estimation of displacement from inertial sensors.     

Nitric oxide synthase in cardiac sarcoplasmic reticulum

NO. is a free radical that modulates heart function and metabolism. We report that a neuronal-type NO synthase (NOS) is located on cardiac sarcoplasmic reticulum (SR) membrane vesicles and that endogenous NO. produced by SR-associated NOS inhibits SR Ca2+ uptake. Ca2+-dependent biochemical conversion of L-arginine to L-citrulline was observed from isolated rabbit cardiac SR vesicles in the presence of NOS substrates and cofactors. Endogenous NO. was generated from the vesicles and detected by electron paramagnetic resonance spin-trapping measurements. Immunoelectron microscopy demonstrated labeling of cardiac SR vesicles by using anti-neuronal NOS (nNOS), but not anti-endothelial NOS (eNOS) or anti-inducible NOS (iNOS) antibodies, whereas skeletal muscle SR vesicles had no nNOS immunoreactivity. The nNOS immunoreactivity also displayed a pattern consistent with SR localization in confocal micrographs of sections of human myocardium. Western blotting demonstrated that cardiac SR NOS is larger than brain NOS (160 vs. 155 kDa). No immunodetection was observed in cardiac SR vesicles from nNOS knockout mice or with an anti-nNOS mu antibody, suggesting the possibility of a new nNOS-type isoform. 45Ca uptake by cardiac SR vesicles, catalyzed by Ca2+-ATPase, was inhibited by NO. produced endogenously from cardiac SR NOS, and 7-nitroindazole, a selective nNOS inhibitor, completely prevented this inhibition. These results suggest that a cardiac muscle nNOS isoform is located on SR of cardiac myocytes, where it may respond to intracellular Ca2+ concentration and modulate SR Ca2+ ion active transport in the heart.     

Comparative analysis of Epstein-Barr virus gene polymorphisms in nasal T/NK-cell lymphomas and normal nasal tissues: implications on virus strain selection in malignancy

Whether particular Epstein-Barr virus (EBV) strains are preferentially selected in malignant diseases remains controversial. Assessment of the importance of strain variation in the pathogenicity of EBV has been hampered principally by the lack of accurate data on the prevalence of virus variants in the normal population. To clarify this issue, a detailed comparative analysis of the EBV genomes contained in normal nasal and nasopharyngeal mucosal tissues and in nasal T/NK-cell lymphoma, which originates at these anatomic sites, was carried out by PCR amplification across the 30-bp deletion and the 33-bp repeat loci in the LMP1 gene and the type-specific polymorphic loci in the EBNA2 and EBNA3C genes and by sequence analysis of the 3' C-terminal region of the LMP1 gene. Whilst the majority of EBV strains in either normal or tumour tissues were type 1 viruses with similar numbers of LMP1 repeats, a marked predominance of LMP1 deletion (del-LMP1) over non-deleted/wild-type LMP1 (wt-LMP1) variants was observed in nasal T/NK-cell lymphoma. Although del-LMP1 variants were also prevalent in the normal carriers of our population, wt-LMP1 was detected at a significantly higher frequency in normal vs. tumour tissues (p = 0.036). More critically, wt-LMP1 variants were found frequently in mixed infection with del-LMP1 variants in the normal carriers. Sequence analysis identified 2 major del-LMP1 (and several wt-LMP1) variants containing signatory nucleotide changes in relation to the prototype B95-8 sequence in both normal and neoplastic nasal tissues. Together, our data provide strong evidence for a selection mechanism for del-LMP1 over the wt-LMP1 variants in tumours.     

Growth of Cu2ZnSnS4 thin films on Si (100) substrates by multisource evaporation

Cu₂ZnSnS₄ films were grown on Si (100) by vacuum evaporation using elemental Cu, Sn, S and binary ZnS as sources. X-ray diffraction patterns of films grown at different substrate temperatures indicated that polycrystalline growth was suppressed and the orientational growths were relatively induced in a film grown at higher temperatures. Tetragonal structure of Cu₂ZnSnS₄ films was confirmed by studying RHEED patterns. The existence of c-axis ([001] direction) growth, two kinds of a-axis (〈100〉 direction) growth and four kinds of {112} twins which can be classified as two symmetrical pairs is proposed. Broad emissions at around 1.45 eV and 1.31 eV were observed in the photoluminescence spectrum measured at 13 K.     

Improved cure optimization in pultrusion with pre-heating and die-cooler temperature

Optimization studies are performed on the pultrusion of a thermosetting composite. The three-dimensional finite element/nodal control volume procedure developed for simulation and optimization of the process is employed for this purpose. The aim of optimization is to achieve the desired degree of cure with minimum local variations across the pultrudate cross-section. The die-heating environment is optimized for a few cases with different initial temperatures for a glass/epoxy wet preform and for the cooler installed within the pultrusion die near its entrance. The role of these temperature parameters in moderating the optimization constraints is examined. Simultaneous optimization of die-heater temperatures and pull-speed is also considered. It is observed that the temperature overshoot within the composite pultrudate can be reduced and better optimization results can be achieved by a proper choice of a pre-die temperature for the composite and the die-cooler temperature.     

Neutral-point voltage control for a three-level DC-AC inverterusing equivalent-input-disturbance approach

One problem with a single source three-level inverter is the drafting of its neutral-point voltage. This may occur during transition or when unbalanced loads are connected to the inverter system. Variation of neutral-point voltage may greatly deteriorate     

Effects of chip rate on selective RAKE combining

The focus of this paper is to characterize the performance of a RAKE receiver tracking the L strongest multipath components and to quantify the effects of the chip rate on spread spectrum systems operating in dense multipath frequency-selective fading environments. Analytical expressions for the symbol error probability are derived in terms of the chip rate, multipath spread of the channel and an arbitrary number of combined paths     

Sample size calculations for studies with correlated observations

Correlated data occur frequently in biomedical research. Examples include longitudinal studies, family studies, and ophthalmologic studies. In this paper, we present a method to compute sample sizes and statistical powers for studies involving correlated observations. This is a multivariate extension of the work by Self and Mauritsen (1988, Biometrics 44, 79-86), who derived a sample size and power formula for generalized linear models based on the score statistic. For correlated data, we appeal to a statistic based on the generalized estimating equation method (Liang and Zeger, 1986, Biometrika 73, 13-22). We highlight the additional assumptions needed to deal with correlated data. Some special cases that are commonly seen in practice are discussed, followed by simulation studies.