Preparation and Characterization of Carboxymethyl Chitosan and β-Cyclodextrin Microspheres by Spray Drying

Three kinds of carboxymethyl chitosan/β-cyclodextrin microspheres loaded with theophylline were prepared by spray drying intended for pulmonary delivery. Mucociliotoxicity, permeation rate, and drug release characteristics of the product were investigated. The microspheres obtained by spray drying were found to be spherical with smooth or wrinkled surfaces. The mean particle size was between 3.39 and 6.06 µm. The microspheres demonstrated high product yield (43.7-50.2%), high drug loading (13.7-38.1%), and high encapsulation efficiency (86.9-92.8%). FT-IR indicated that there were interactions of theophylline with carboxymethyl chitosan matrix. Further studies on mucociliotoxicity and permeation confirmed that microspheres had better adaptability and high permeation rate. In vitro drug release from the microspheres was not related to the drug/polymer ratios.     

单孔护壁爆破数值模拟

运用LS-DYNA软件对单孔护壁爆破和切缝药包爆破进行了三维数值模拟,结果显示,由于PVC-U套管的存在,作用于孔壁的爆炸应力波峰值被显著削弱,降低率达到30%～46%,并推迟了其到达保留岩体孔壁时间.与传统的切缝药包爆破相比,保留岩体损伤更小.     

寻找无效或低效生产层的方法

注水和产液量加大是导致特高含水期油气生产成本上升的主要要素，如何寻找无效或低效生产层、控制无效或低效注水及产液量已成为搞好综合调整、降低油气生产成本的关键问题。因此，从理论分析、实验数据及经验值等方面分析、探讨了以累积注水倍数、数值模拟计算、吸水剖面资料、油井找水资料、注水井分层压力降落速度、精细地质研究等为依据的6种寻找无效或低效生产层的方法，并将其应用于喇嘛甸油田。实践表明，以累积注水倍数为依据，同时结合测井、试井资料，能够比较准确地判断无效或低效生产层。     

Hartstoffschichten für das Pressen und Prägen von Gläsern bei hohen Temperaturen

Hard and wear resistant coatings for the moulding and embossing of glasses at elevated temperatures Hard and wear resistant coatings of Titanium Aluminium Nitride TiAlN were deposited on various substrates by the application of different reactive deposition processes: RF-magnetron-sputtering, ion beam-sputtering and by the energetic cluster impact (ECI) process. The deposition of the coatings was performed under variation of biasing conditions and of process parameters such as pressures and flow rates of the process gases argon and nitrogen as well as of energies of species hitting the substrate surfaces. The microstructure particularly the growth morphology of several films was investigated by pictures of film cross sections recorded by transmission electron microscopy. Residual intrinsic film stresses were analyzed by measuring deflections of substrates in an interference optical microscope before and after the deposition of the coatings. By heating coated substrates and in-situ observation of deflections at elevated temperatures dependencies of thermally induced stresses on temperatures and variations of intrinsic stresses due to changes within the films could be analyzed and related to microstructure and growth conditions. In the paper specific characteristics of the deposition processes occuring on the scale both of atoms and of clusters which may contain several thousand of atoms are described and related to microstructure, residual stress states and damaging conditions. Different contributions to residual film stresses are analyzed on the base of theoretical considerations taking into account deposition kinetics and thermomecanical properties. The significance of achieved film properties for application, i. e. for the coating of tools for the manufacturing of optical components by moulding and embossing of glasses is discussed.     

硬质合金与铁基复合材料热等静压扩散连接

以烧结结态硬质合金和粉末态铁基复合材料为连接对象，研究了两种材料的热等静压扩攻连接工艺，获得了直接连接接头和加镍作中间过渡层的间接连接接头，考察了接头的结合界面形貌，界面的元素扩散和界面结合强度。     

稀土萃取信息系统

应稀土化学发展的需要,我们组建了稀土萃取信息系统。其中包括:数据的来源和数据类型;数据的组织;检索功能;数据间的关联;最优化设计以及萃取剂结构与其物理性质和结构与萃取性能的相关分析研究。     

佛尔哈德法测定氯化除汞上清液中的氯量

控制pH4-6，用锌粉还原氯化除汞上清液中的汞（Ⅱ）离子，取置换后液加入过量的硝酸银标准溶液，以硫酸铁铵溶液作指示剂，用硫氰酸钾标准滴定溶液滴定来测定氯量。该方法的检出限：0．25mg／100mL，回收率：98％-101％。     

注塑件/模具成本评估方法研究综述

对注塑模成本评估领域的主要研究方法进行了分析 ,指出了相关的几个成本评估流派。着重对成本评估的CEF方法进行了总结 ,并对当前国际上流行的派别的优缺点进行了总结。文末 ,给出了我们的研究思路大体概述     

浅谈如何做一名新时期创新型教师

教师的职业道德是贯穿教育全过程的精神支柱,它对学生和社会都会有深远的激励和影响作用;而熟练掌握专业知识和教育理论知识是教师业务能力的本质要求。新时期的创新型教师都必须不断地在这两个方面进行提升才能够符合时代的要求。     

矫直状态下钢管弹塑性变形区的研究

根据钢管矫直时的变形规律，通过对矫直中钢管的力学状态及矫直前后的状态参数分析，建立了一种适于现场应用的确定钢管弹、塑性变形区的新方法。