YBa2Cu3O7—δ超导体中决定Tc的两个内禀因素

本文综合报导我们研究组在YBa_2Cu_3O_(7-δ)的元素替代效应研究中所获得的实验结果和从中获得的重要结论。实验结果表明:正交晶体结构、氧含量、Cu的氧化价态,以及金属——半导体(绝缘体)相变等都只是决定Tc的表观因素;存在着CuO_2平面外和CuO_2平面上元素替代的两种不同机制;体系的载流子浓度和CuO_2平面上Cu原子间的动力学的短程反铁磁关联是决定Tc的两个内禀因素。Y系123相双元素替代和Bi系2212相的实验结果进一步证实了上述结论。     

产学研用联合培养应用型化学人才的实践与探索

在地方本科高校将实行转型,向应用技术型和职业教育类型转型的形势下,应用化学专业积极探索适合地方本科高校培养应用型化学专业人才的教育模式,采取生产、教学、科研与应用多种结合途径,提高了学生的综合素质和职业能力,提升教师的工程素质。     

Biological Evaluation and 3D-QSAR Studies of Curcumin Analogues as Aldehyde Dehydrogenase 1 Inhibitors

Aldehyde dehydrogenase 1 (ALDH1) is reported as a biomarker for identifying some cancer stem cells, and down-regulation or inhibition of the enzyme can be effective in anti-drug resistance and a potent therapeutic for some tumours. In this paper, the inhibitory activity, mechanism mode, molecular docking and 3D-QSAR (three-dimensional quantitative structure activity relationship) of curcumin analogues (CAs) against ALDH1 were studied. Results demonstrated that curcumin and CAs possessed potent inhibitory activity against ALDH1, and the CAs compound with ortho di-hydroxyl groups showed the most potent inhibitory activity. This study indicates that CAs may represent a new class of ALDH1 inhibitor.     

Discovery and in Vivo Evaluation of Novel RGD-Modified Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery

In the current study, the lipid-shell and polymer-core hybrid nanoparticles (lpNPs) modified by Arg–Gly–Asp(RGD) peptide, loaded with curcumin (Cur), were developed by emulsification-solvent volatilization method. The RGD-modified hybrid nanoparticles (RGD–lpNPs) could overcome the poor water solubility of Cur to meet the requirement of intravenous administration and tumor active targeting. The obtained optimal RGD-lpNPs, composed of PLGA (poly(lactic-co-glycolic acid))–mPEG (methoxyl poly(ethylene- glycol)), RGD–polyethylene glycol (PEG)–cholesterol (Chol) copolymers and lipids, had good entrapment efficiency, submicron size and negatively neutral surface charge. The core-shell structure of RGD–lpNPs was verified by TEM. Cytotoxicity analysis demonstrated that the RGD–lpNPs encapsulated Cur retained potent anti-tumor effects. Flow cytometry analysis revealed the cellular uptake of Cur encapsulated in the RGD–lpNPs was increased for human umbilical vein endothelial cells (HUVEC). Furthermore, Cur loaded RGD–lpNPs were more effective in inhibiting tumor growth in a subcutaneous B16 melanoma tumor model. The results of immunofluorescent and immunohistochemical studies by Cur loaded RGD–lpNPs therapies indicated that more apoptotic cells, fewer microvessels, and fewer proliferation-positive cells were observed. In conclusion, RGD–lpNPs encapsulating Cur were developed with enhanced anti-tumor activity in melanoma, and Cur loaded RGD–lpNPs represent an excellent tumor targeted formulation of Cur which might be an attractive candidate for cancer therapy.     

Enhanced thermoelectric effect of carbon fiber reinforced cement composites by metallic oxide/cement interface

Thermoelectric power of carbon fiber reinforced cement composites was firstly enhanced efficiently by metallic oxide microparticles in the cement matrix. The absolute Seebeck coefficient of these composites increased steadily with increasing metallic oxide content and achieved 4–5 folds of the original one. The largest absolute thermoelectric power of +100.28 µV/°C was obtained for the composite with 5.0 wt% Bi₂O₃ microparticles. The carrier scattering of the interface between oxide microparticles and cement matrix is probably attributed to the Seebeck effect enhancement.     

Human Adipose-Derived Mesenchymal Progenitor Cells Engraft into Rabbit Articular Cartilage

Mesenchymal stem cells (MSCs) are known to have the potential for articular cartilage regeneration, and are suggested for the treatment of osteoarthritis (OA). Here, we investigated whether intra-articular injection of xenogeneic human adipose-derived mesenchymal progenitor cells (haMPCs) promoted articular cartilage repair in rabbit OA model and engrafted into rabbit articular cartilage. The haMPCs were cultured in vitro, and phenotypes and differentiation characteristics of cells were evaluated. OA was induced surgically by anterior cruciate ligament transection (ACLT) and medical meniscectomy of knee joints. At six weeks following surgery, hyaluronic acid (HA) or haMPCs was injected into the knee joints, the contralateral knee served as normal control. All animals were sacrificed at the 16th week post-surgery. Assessments were carried out by macroscopic examination, hematoxylin/eosin (HE) and Safranin-O/Fast green stainings and immunohistochemistry. The data showed that haMPC treatment promoted cartilage repair. Signals of human mitochondrial can be directly detected in haMPC treated cartilage. The haMPCs expressed human leukocyte antigen I (HLA-I) but not HLA-II-DR in vivo. These results suggest that intra-articular injection of haMPCs promotes regeneration of articular cartilage in rabbit OA model, and support the notion that MPCs are transplantable between HLA-incompatible individuals.     

两片成组输送用于浮法冷修改造主线90°拐弯

本文就某厂浮法冷修改造主线９０°拐弯。介绍了在变速输送中两片组的形成、计算，两片成组玻璃在支线及主线末端的卸板     

非水分散聚合

本文综述了非水分散聚合体系的组成、表征、理论研究（如稳定机理、聚合机理、反应动力学）及实际应用等方面的情况。     

四种不同产地无烟煤性能研究

对四种国产无烟煤的化学成分、氧化率和岩相结果进行了分析，以及用此四种无烟煤在相同工艺条件下制成的微孔炭砖试样进行了试验研究。结果表明，阳泉煤制成的微孔炭砖性能优良，且阳泉煤变质程度最好，是生产微孔炭砖最为理想的原料；宁夏太西煤只要控制好煅烧质量，也是生产微孔炭砖的优质原料。