The beta 1 integrin, very late activation antigen-4 on human neutrophils can contribute to neutrophil migration through connective tissue fibroblast barriers

Polymorphonuclear leucocyte (PMNL) accumulation in extravascular tissues and inflammatory exudates is dependent on their migration through blood vessel endothelium and then through connective tissue. Previously we utilized a barrier of human synovial and dermal fibroblasts (HSF or HDF) grown on microporous filters, as a model of PMNL migration through connective tissue. Those studies showed that beta 2 (CD18) and the beta 1 integrins, very late activation antigen-5 (VLA-5) and VLA-6, in part mediate this PMNL migration. Here we report that VLA-4, which can also be expressed at low levels on activated PMNL, is also involved in PMNL migration induced by C5a through fibroblast (HSF and HDF) barriers, because monoclonal antibody (mAb) to VLA-4 significantly inhibited (by 20-30%) PMNL migration. Blocking the function of CD18, VLA-5 or VLA-6 was not required for detection of the VLA-4-mediated migration. Combination treatment with mAb to VLA-4 and with mAb to VLA-5 or to VLA-6 further inhibited PMNL migration, irrespective of whether CD11/CD18 mechanisms were blocked with anti-CD18 mAb or not. Treatment of PMNL with a peptide based on the VLA-4-binding domain in the CS-1 fragment of fibronectin, but not a control peptide, inhibited PMNL migration to a comparable extent to treatment with mAb to VLA-4. A low level of VLA-4 was expressed on C5a-activated PMNL, detected by immunofluorescence flow cytometry. These results suggest that VLA-4 can be mobilized by human peripheral blood PMNL and can, in addition to VLA-5, VLA-6 and CD11/CD18 integrins, mediate PMNL migration through connective tissue. This is in marked contrast to PMNL transendothelial migration, where beta 1 integrins appear to play no significant role.     

广义杠杆规则及其在配方计算中的应用

作者将相图中的一维杠杆规则推广至多元配料系统而成为广义杠杆规则，并利用这一规则对配方计算中解的可行域问题进行了深入的讨论，给出了几何解释及工艺诠释，对配方设计有一定的指导作用。     

Dynamic lithium-ion battery model for system simulation

Presents here a complete dynamic model of a lithium ion battery that is suitable for virtual-prototyping of portable battery-powered systems. The model accounts for nonlinear equilibrium potentials, rate- and temperature-dependencies, thermal effects and response to transient power demand. The model is based on publicly available data such as the manufacturers' data sheets. The Sony US18650 is used as an example. The model output agrees both with manufacturer's data and with experimental results. The model can be easily modified to fit data from different batteries and can be extended for wide dynamic ranges of different temperatures and current rates.     

电子膨胀阀在电子吊舱制冷系统中的应用研究

介绍了军用飞机电子吊舱蒸汽压缩制冷环境控制系统的工作特点，给出了电子膨胀阀在电子吊舱地面模拟制冷系统中的初步试验研究结果。     

变井储系数的确定方法及其在反褶积分析中的应用

中针对变井储试井分析问题，给出了确定变井储系数及计算续流量的方法，并用反褶积分析积分析方法解释了未出现径向流的早期测压数据，给出了解决早期试井资料分析问题的有效方法。     

油气集输管道最佳敷设方式的分析

根据大庆油田油气集输工艺设计的实践，分析了几种实用的油气集输管道敷设方式的优缺点。在对不同敷设方式的管道热耗做了较详细计算的基础上，进行了比较，提出了确定油气集输管道的最佳敷设方式：站外管道基本上采用埋地敷设；站内管道则应依据站址处的常年最高地下水位资料来确定，即在保证管道不长期受地下水浸泡的前提下，站内室外管道以埋地敷设为主，室内管道以架空与理地同时敷设为最佳；地下水位高的站内，以架空敷设最佳。     

复杂目标近场电磁散射的可视化计算方法

首次介绍了复杂目标近场散射计算的可视化方法。采用非均匀有理Ｂ样条曲面（ＮＵＲＢＳ）精确构造任意形状散射体，结合几何体近场透视变换和Ｚ－Ｂｕｆｆｅｒ技术实现了基于Ｗｉｎｄｏｗｓ平台的近场散射计算。提出广义雷达散射截面的概念并给出的若干算例。该方法充分利用了计算机３Ｄ图形设备的几何运算能力，运算速度快，严谨高，可扩展性好。     

高温超导研究的新进展

本文简要回顾了一年来高温超导的新进展，特别介绍和讨论了新型高温超导体系和线材、带材、块材及薄膜应用的发展情况。     

Si_（1－x）Ge_x／Si定向耦合器的研制

在运用ＳｉＧｅ脊形波导单模条件和有效折射率法分析ＳｉＧｅ／Ｓｉ定向耦合器结构参数的基础上，采用分子束外延和各向异性腐蚀技术制备出Ｓｉ１－ｘＧｅｘ／Ｓｉ（ｘ＝０．０５）单模定向耦合器．在波长为１．３μｍ时，平均串音小于－１８．１ｄＢ，输出功率耦合效率达到９８．１％