A 16-bit 1 MSPS SAR ADC with foreground calibration and residual voltage shift strategy

In this paper, a 16-bit 1MSPS foreground calibration successive approximation register analog-to-digital converter (SAR ADC) is developed by the CMOS 0.25 μm process. An on-chip all-digital foreground weights calibration technique integrating self-calibration weight measurement with PN port auto-balance technique is designed to improve the performance and lower the costs of the developed SAR ADC. The SAR ADC has a chip area of 2.7 × 2.4 mm², and consumes only 100 μW at the 2.5 V supply voltage with 100 KSPS. The INL and DNL are both less than 0.5 LSB.     

基于改进SSD的航天发动机试验报警方法

航天发动机是导弹和火箭的推进装置,其可靠性直接影响航天器的性能。发动机试验是航天发动机的研发、应用过程中不可或缺的一环,其中发动机试验影像是判断发动机性能的重要数据。针对发动机点火故障影像中出现火星等异常情况的突发性和隐蔽性,提出一种基于改进单发多框检测(SSD)的航天发动机试验预警方法。该方法在SSD目标检测算法的基础上,使用算法性能更强的深度残差网络替代原有基础网络,以提高目标检测的精度。同时,针对SSD目标检测算法对小尺度样本的漏检特性,提出基于先验尺度调整的改进措施,提高算法在此种应用环境下的小尺度样本的检测精度。实验表明,该算法适用于航天发动机试验预警应用,且在准确性和实时性上表现良好。     

Developing MXenes from Wireless Communication to Electromagnetic Attenuation

There is an urgent global need for wire-less communication utilizing materials that can provide simultaneous flexibility and high conductivity.Avoiding the harm...     

Event vertex and time reconstruction in large-volume liquid scintillator detectors

Large-volume liquid scintillator detectors with ultra-low background levels have been widely used to study neutrino physics and search for dark matter. Event ve...     

THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors

Multiple myeloma (MM) is a hematological disease marked by abnormal growth of B cells in bone marrow. Inherent chromosomal instability and DNA damage are major hallmarks of MM, which implicates an aberrant DNA repair mechanism. Studies have implicated a role for CDK12 in the control of expression of DNA damage response genes. In this study, we examined the effect of a small molecule inhibitor of CDK12–THZ531 on MM cells. Treatment of MM cells with THZ531 led to heightened cell death accompanied by an extensive effect on gene expression changes. In particular, we observed downregulation of genes involved in DNA repair pathways. With this insight, we extended our study to identify synthetic lethal mechanisms that could be exploited for the treatment of MM cells. Combination of THZ531 with either DNA-PK inhibitor (KU-0060648) or PARP inhibitor (Olaparib) led to synergistic cell death. In addition, combination treatment of THZ531 with Olaparib significantly reduced tumor burden in animal models. Our findings suggest that using a CDK12 inhibitor in combination with other DNA repair inhibitors may establish an effective therapeutic regimen to benefit myeloma patients.     

BOPP薄膜市场现状及发展趋势

介绍了我国双向拉伸聚丙烯薄膜的市场现状,并对其发展趋势进行了展望。     

Wire-in-Wire TiO2/C Nanofibers Free-Standing Anodes for Li-Ion and K-Ion Batteries with Long Cycling Stability and High Capacity

Wearable and portable mobile phones play a critical role in the market,and one of the key technologies is the flexible electrode with high spe-cific capacity an...     

Analysis of miRNA Expression Profiling of RIP2 Knockdown in Chicken HD11 Cells When Infected with Avian Pathogenic E. coli (APEC)

Colibacillosis is an acute and chronic avian disease caused by avian pathogenic E. coli (APEC). Previous studies have demonstrated that RIP2 plays a significant role in APEC infection. Moreover, increasing evidence indicates that microRNAs (miRNAs) are involved in host–pathogen interactions and the immune response. However, the role of miRNAs in the host against APEC infection remains unclear. Herein, we attempted to reveal new miRNAs potentially involved in the regulation of the immune and inflammatory response against APEC infection, with a particular focus on those possibly correlated with RIP2 expression, via miRNA-seq, RT-qPCR, Western blotting, dual-luciferase reporter assay, and CCK-8. The results showed that a total of 93 and 148 differentially expressed (DE) miRNAs were identified in the knockdown of RIP2 cells following APEC infection (shRIP2+APEC) vs. knockdown of RIP2 cells (shRIP2) and shRIP2 vs. wild-type cells (WT), respectively. Among those identified DE miRNAs, the biological function of gga-miR-455-5p was investigated. It was found that gga-miR-455-5p regulated by RIP2 was involved in the immune and inflammatory response against APEC infection via targeting of IRF2 to modulate the expression of type I interferons. Additionally, RIP2 could directly regulate the production of the type I interferons. Altogether, these findings highlighted the crucial role of miRNAs, especially gga-miR-455-5p, in host defense against APEC infection.     

Unfolding core asymmetries with x-ray emission images in symmetry diagnostic experiments

A novel inversion technique is proposed to unfold core asymmetries at the source with x-ray emission images, which were obtained from imploded surrogate capsules in symmetry diagnostic experiments. The axisymmetrical core emission can be expanded as a Fourier series, with Legendre polynomials and spherical Bessel functions as bases concerned with polar angle and radius, respectively. A least-squares estimator is employed to obtain the unknown coefficients from its two-dimensional image data. The unfolded Legendre coefficients can be further used to test modeling of drive asymmetries in hohlraums. This technique is also demonstrated with a proof-of-principle experiment performed on the Shenguang II laser facility [L. Zunqi et al., Chin. J. Lasers B10, 6 (2001)].     

Nanoindentation measurement of core–skin interphase viscoelastic properties in a sandwich glass composite

Mechanics of Time-Dependent Materials - Debonding at the core–skin interphase region is one of the primary failure modes in core sandwich composites under shear loads. As a result, the...