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131.
Li Z.-M. Landheer D. Veilleux M. Conn D.R. Surridge R. Xu J.M. McDonald R.I. 《Photonics Technology Letters, IEEE》1992,4(5):473-476
The authors have developed a 2-D device simulator for heterostructure metal-semiconductor-metal (MSM) photodetectors. They have incorporated a model of multilayer optics into the simulator and used it to analyze the temporal response of a resonant-cavity enhanced heterostructure with a confining buffer layer and a distributed Bragg reflector (DBR). The authors show that through fine tuning the layer thicknesses, optical resonance enhancement of the light absorption can be obtained 相似文献
132.
Prostaglandin A2 (PGA2) potently inhibits cell proliferation and suppresses tumor growth in vivo, but little is known regarding the molecular mechanisms mediating these effects. Here we demonstrate that treatment of breast carcinoma MCF-7 cells with PGA2 leads to G1 arrest associated with a dramatic decrease in the levels of cyclin D1 and cyclin-dependent kinase 4 (cdk4) and accompanied by an increase in the expression of p21. We further show that these effects occur independent of cellular p53 status. The decline in cyclin D and cdk4 protein levels is correlated with loss in cdk4 kinase activity, cdk2 activity is also significantly inhibited in PGA2-treated cells, an effect closely associated with the upregulation of p21. Immunoprecipitation experiments verified that p21 was indeed complexed with cdk2 in PGA2-treated cells. Additional experiments with synchronized MCF-7 cultures stimulated with serum revealed that treatment with PGA2 prevents the progression of cells from G1 to S. Accordingly, the kinase activity associated with cdk4, cyclin E, and cdk2 immunocomplexes, which normally increases following serum addition, was unchanged in PGA2-treated cells. Furthermore, the retinoblastoma protein (Rb), a substrate of cdk4 and cdk2 whose phosphorylation is necessary for cell cycle progression, remains underphosphorylated in PGA2-treated serum-stimulated cells. These findings indicate that PGA2 exerts its growth-inhibitory effects through modulation of the expression and/or activity of several key G1 regulatory proteins. Our results highlight the chemotherapeutic potential of PGA2, particularly for suppressing growth of tumors lacking p53 function. 相似文献
133.
Q Hu M Trevisan Y Xu W Dong SA Berger SD Lyman MD Minden 《Canadian Metallurgical Quarterly》1995,95(6):2530-2538
The growth of human leukemic cells in culture and in vivo is dependent upon the presence of hematopoietic growth factors. Most populations of human leukemic acute myeloblastic leukemia (AML) cells express c-Kit on their surface and respond to Kit ligand (KL) in culture. To determine if this interaction was of potential significance in vivo we used a mouse model system. 32D cells, a murine IL-3-dependent myeloid cell line, were rendered KL responsive by transfection of the murine c-Kit. After injection of 32D or 32D-Kit cells into syngeneic hosts, animals bearing 32D-Kit cells, but not 32D cells, became moribund and were killed. These animals had circulating leukemic blast cells, infiltration of bone marrow, spleen, brain, liver, lung, and kidney. Cells recovered from some of the animals continued to be dependent upon IL-3 or KL for growth while in other cases the cells were factor independent. This model illustrates that the constitutive expression of c-Kit enhances the leukemic potential of 32D cells. The model will be useful for studying the progression of leukemia in vivo and testing whether interruption of the interaction of Kit and KL can affect the growth of leukemic cells. 相似文献
134.
Performance analysis of the bidirectional associative memory and animproved model from the matched-filtering viewpoint 总被引:1,自引:0,他引:1
Bai-Ling Zhang Bing-Zheng Xu Chung-Ping Kwong 《Neural Networks, IEEE Transactions on》1993,4(5):864-872
This paper discusses the bidirectional associative memory (BAM) model from the matched-filtering viewpoint and offers it a new interpretation. Our attention is focused on the problem of stability and attractivity of equilibrium states. Several sufficient and/or necessary conditions are presented. To improve the BAM performance, an exponential function is used to enhance the correlations between the binary vectors of the retrieval key and that of the stored pattern similar to the key. The modified model is shown to be asymptotically stable. Theoretical analysis and simulation results demonstrate that the modified model performs much better than the original BAM in terms of memory capacity and error correction capability. 相似文献
135.
136.
Fanggao Chang Tao Li Yongxia Ge Zhenping Chen Zhongshi Liu Xiping Jing 《Journal of Materials Science》2007,42(17):7109-7115
DC resistivity, dielectric constant, dielectric loss and positron annihilation spectra of (Ba1−x
Ho
x
)TiO3 ceramics have been measured as a function of holmium concentration x. It has been found that the DC resistivity of (Ba1−x
Ho
x
)TiO3 is strongly dependent on the Ho content: it decreases three orders of magnitude and reaches a minimum at x = 0.4%. Doping with 0.6% holmium increases the permittivity of BaTiO3 by approximately three times (from ∼1,300 to ∼4,000), with only a slight increase in the corresponding dielectric loss. The
local electron density and defect concentration estimated using positron annihilation technique conforms well to the features
found in the dielectric and resistivity measurements. The results have been discussed in terms of a mixed compensation model. 相似文献
137.
W. Tang H.Z. Shi G. Xu B.S. Ong Z.D. Popovic J.C. Deng J. Zhao G.H. Rao 《Advanced materials (Deerfield Beach, Fla.)》2005,17(19):2307-2311
138.
Document caching and connection caching are extensively studied problems. In document caching, one has to maintain caches
containing documents accessible in a network. In connection caching, one has to maintain a set of open network connections
that handle data transfer. Previous work investigated these two problems separately while in practice the problems occur together:
In order to load a document, one has to establish a connection between network nodes if the required connection is not already
open. In this paper we present the first study that integrates document and connection caching. We first consider a very basic
model in which all documents have the same size and the cost of loading a document or establishing a connection is equal to
1. We present deterministic and randomized online algorithms that achieve nearly optimal competitive ratios unless the size
of the connection cache is extremely small. We then consider general settings where documents have varying sizes. We investigate
a FAULT model in which the loading cost of a document is 1 as well as a BIT model in which the loading cost is equal to the
size of the document. 相似文献
139.
Non-redundant data clustering 总被引:6,自引:6,他引:0
Data clustering is a popular approach for automatically finding classes, concepts, or groups of patterns. In practice, this
discovery process should avoid redundancies with existing knowledge about class structures or groupings, and reveal novel,
previously unknown aspects of the data. In order to deal with this problem, we present an extension of the information bottleneck
framework, called coordinated conditional information bottleneck, which takes negative relevance information into account by maximizing a conditional mutual information score subject to
constraints. Algorithmically, one can apply an alternating optimization scheme that can be used in conjunction with different
types of numeric and non-numeric attributes. We discuss extensions of the technique to the tasks of semi-supervised classification
and enumeration of successive non-redundant clusterings. We present experimental results for applications in text mining and
computer vision. 相似文献
140.