同源连杆机构构成特性和传动角的研究

从理论上揭示了原始机构及其同源机构在尺寸型上的内在联系,即它们的确生成了同一条轨迹.还提出,同源机构与原始机构的对应构件有相同的角速度;在通常使用情况下,同源四杆机构与原始四杆机构具有相同的传动角.     

全固体化Nd：YVO_4单频绿光激光器

采用“面对面”激光二极管泵浦Ｎｄ：ＹＶＯ４和ＫＴＰ内腔倍频，获得单横模单纵横绿光输出。阈值泵浦功率为１２ｍｗ，实测的单端绿光最大单横模输出为７．３ｍｗ，最大单纵模输出为１．５ｍｗ，光光转换效率为１．９％。全固化系统设计小型紧凑，运转可靠。     

压力表常见故障与维修技术分析

随着我国现代化发展的不断加快,很多领域都使用高科技自动控制仪器.压力表的维修、安装与调试过程直接关系到工业生产,压力表的准确度对安全生产尤为重要,研究常见故障的维修技术是有效保证机械测量的准确性和可靠性.本文从影响压力表准确度的主要因素出发,着重介绍了压力表常见的一些故障,并且进行原因分析找出合理的维修处理方法,旨在不断提高压力表的准确度、操作水平和工艺.     

冠醚液晶/PVC二元复合膜的温控离子渗透作用(英文)

冠醚液晶具有液晶的有序性和冠醚络合金属离子的特性,采用单臂冠醚液晶成功地用粒模拟生物膜的离子传输,首次提出了冠醚液晶和PVC的二元复合膜,这种新的仿生膜模型种巧妙地模拟生物膜的温控传输,能更充分发挥膜传输中液晶的基本功能。因此,提出了冠醚液晶分子在液晶志时能自组装成离子通道传输离子。     

铝电解电容器的温度加速因子

采用温度作为铝电解电容器寿命加速因子,通常根据“１０℃法则”或“７℃法则”计算。作者通过对６３Ｖ－４７μＦ铝电解电容器在四种不同温度下的负荷试验（＋８５℃、＋９５℃、＋１０５℃、＋１１５℃）后对数百只样品、数万个测量数据进行了处理分析。认为单纯地使用“１０℃法则”或“７℃法则”不能准确地描述温度加速因子。作者结合铝电解电容器的结构,分析了铝电解电容器的失效因素,给出了负荷试验中温度与铝电解电容器寿命的关系。     

非平衡磁控溅射TiAlN薄膜的抗高温氧化行为研究

采用非平衡磁控溅射技术在Q235钢基体上制备了TiAlN薄膜,通过精密电子天平、纳米力学探针、划痕测试仪及扫描电镜等测试分析,研究了薄膜氧化动力学行为、薄膜显微硬度和结合力的变化规律及不同温度下氧化后薄膜表面形貌演变规律,探讨了Ti AlN薄膜的抗高温氧化机制。结果表明,在700℃以上TiAlN薄膜的氧化动力学行为服从抛物线规律。随着氧化温度的升高,薄膜的显微硬度和结合力逐渐下降,当氧化温度升高到800℃时,薄膜具有较高的显微硬度和结合力,分别为19.3 GPa和32.1 N,表现出良好的抗高温氧化性能。当氧化温度升高到900℃时,薄膜表面出现了明显的鼓包和裂纹,此时薄膜发生了严重氧化,薄膜已失去对基体的保护作用。     

Comprehensive Analysis of hsa-miR-654-5p’s Tumor-Suppressing Functions

The pivotal roles of miRNAs in carcinogenesis, metastasis, and prognosis have been demonstrated recently in various cancers. This study intended to investigate the specific roles of hsa-miR-654-5p in lung cancer, which is, in general, rarely discussed. A series of closed-loop bioinformatic functional analyses were integrated with in vitro experimental validation to explore the overall biological functions and pan-cancer regulation pattern of miR-654-5p. We found that miR-654-5p abundance was significantly elevated in LUAD tissues and correlated with patients’ survival. A total of 275 potential targets of miR-654-5p were then identified and the miR-654-5p-RNF8 regulation axis was validated in vitro as a proof of concept. Furthermore, we revealed the tumor-suppressing roles of miR-654-5p and demonstrated that miR-654-5p inhibited the lung cancer cell epithelial-mesenchymal transition (EMT) process, cell proliferation, and migration using target-based, abundance-based, and ssGSEA-based bioinformatic methods and in vitro validation. Following the construction of a protein–protein interaction network, 11 highly interconnected hub genes were identified and a five-genes risk scoring model was developed to assess their potential prognostic ability. Our study does not only provide a basic miRNA-mRNA-phenotypes reference map for understanding the function of miR-654-5p in different cancers but also reveals the tumor-suppressing roles and prognostic values of miR-654-5p.