Effect of the sulfonylurea glyburide on glycogen synthase activity in alloxan-induced diabetic rat adipocytes

1. The effect of glyburide (glibenclamide) treatment in vivo on the adipose tissue glycogen synthase activity of type II diabetic rats has been studied. 2. Three week treatment of diabetic animals with glyburide (5 mg/kg orally, in saline) increased adipose glycogen synthase activity and decreased blood glucose levels. 3. These results demonstrate that the sulfonylurea glyburide is capable of exerting direct insulin-like effect on adipose glycogen-synthase activity of type II diabetic rats in vivo.     

CAN总线在电动汽车BMS系统与充电桩之间通信的应用

电动汽车是我国新能源战略重点之一,国家电网公司为此积极展开电动汽车充电站的建设。国家电网将按照换电为主、插充为辅,集中充电、统一配送为基本商业模式,加快电动汽车充换电站的布局和建设。不论是插充方式还是集中充电,电动汽车的普及都离不开充电智能化,而BMS与充电桩或其他充电设备的无缝连接正是实现充电智能化的必要条件。文章提出了BMS管理系统与充电桩之间的通信设计方案,利用CANBUS实现BMS管理系统与充电桩的通讯,介绍了CAN通讯的硬件设计和软件设计,并经过与充电桩的反复测试,实现了BMS管理系统与充电桩的通信。     

乙炔吸收系统倒开车实现装置产品快速合格

中国石油吉林石化公司聚乙烯厂700kt/a乙烯装置老区采用溶剂吸收技术脱出乙炔精制乙烯工艺。多年来,乙炔吸收塔塔顶回流泵开车初期不上量问题一直制约着装置开车进度。经过摸索,技术人员尝试对开车流程进行调整,攻克了难题。文中对该装置具体的调整措施进行了阐述。     

空气压缩机组联动控制系统改造

本文分析空压机原联动控制系统的运行特点，对系统进行改造，利用自制电子式两位差动可调控制器取代压力控制器，克服原系统的缺陷。达到了改造的目的。     

大型油罐安装与焊接

讨论大型贮油罐的底板、壁板和顶板的铺设、吊装和焊接工艺。从安装、组对、焊材选用、焊接顺序、坡口形式到焊接检验、验收标准均进行了详细叙述。     

获得高熔敷速度与低稀释率的等离子粉末堆焊方法

对传统的堆焊方法而言，提高熔敷速度与降低稀释率是矛盾的，能否协调这两方面因素，是实现高效高质堆焊效果的关键，分析了提高熔敷速度，降低稀释率的各种途径，并基于理论的分析与工艺验证，提出采用小压缩孔径，拉长粉末会交点于工件距离是同时获得高熔敷速度，低稀释率堆焊效果的有效途径。     

Dismantling discrimination in dental education

In existence for more than 100 years, the schools of medicine and dentistry of Howard University and Meharry Medical College have been responsible for training the majority of African-American physicians and dentists. The dissolution of the doctrine of "separate but equal" has resulted in the acceptance of larger numbers of African-American health professionals to America's medical and dental educational institutions. The University of Tennessee School of Dentistry is a primary example of a formerly segregated institution that has changed its policies and presently possesses a respectable number of African-American dental alumni. In a recent acknowledgment of this fact on Alumni Day, black graduates of this University celebrated and sponsored a program to increase the number of African-American matriculants at the school.     

考虑几何非线性的结构形状优化灵敏度分析

基于非线性增量有限元理论,给出了全拉格朗日描述下的空间结构优化设计有限元刚度表达式,导出了考虑几何非线性项的结构形状优化位移灵敏度和应力灵敏度的计算公式,并通过数值算例验证了公式的正确性和有效性,同时表明灵敏度分析中,考虑几何非线性项将显著提高优化设计的效率和精度。     

DK5-1600智能型低压真空断路器

DK5－1600智能型低压真空断路器是联合开发的新产品。本文介绍该产品的适用范围、结构、原理、特点、基本参数和技术性能及主要应用。     

T lymphocyte responses to anti-neutrophil cytoplasmic autoantibody (ANCA) antigens are present in patients with ANCA-associated systemic vasculitis and persist during disease remission

The cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel has been identified in the cardiac muscle of a number of mammalian species, including humans. The goal of this study was to begin quantifying the structural requirements necessary for arylaminobenzoate block of the CFTR channel. The cardiac cAMP-dependent Cl- current (ICl) was measured using the whole-cell arrangement of the patch-clamp technique in guinea pig ventricular myocytes during stimulation of protein kinase A with forskolin. At drug concentrations below the IC50 value for channel block, reduction of ICl by the arylaminobenzoates occurred in a strongly voltage-dependent manner with preferential inhibition of the inward currents. At higher drug concentrations, block of both the inward and outward ICl was observed. Increasing the length of the carbon chain between the benzoate and phenyl rings of the arylaminobenzoates resulted in a marked increase in drug block of the channel, with IC50 values of 47, 17, and 4 microM for 2-benzylamino-5-nitro-benzoic acid, 5-nitro-2-(2-phenylethylamino)-benzoic acid, and 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB), respectively. Increasing the carbon chain length further with the compound 5-nitro-2-(4-phenylbutylamino)-benzoic acid, caused no additional increase in the potency of drug block (IC50 = 4 microM). Inhibition of ICl by the arylaminobenzoates was modulated by the pH of the external solution; increasing the pH from 7.4 to 10.0 greatly weakened NPPB block, whereas decreasing the pH to 6.4 enhanced block. In addition, block of ICl was observed during intracellular dialysis of NPPB, and this action was not affected by raising the external pH.