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101.
Francillette Yannick Boucher Eric Bier Nathalie Lussier Maxime Bouchard Kévin Belchior Patricia Gaboury Sébastien 《User Modeling and User-Adapted Interaction》2020,30(5):895-947
User Modeling and User-Adapted Interaction - Intelligent environments may improve the independence and quality of life of persons with mild cognitive impairment (MCI) or Alzheimer’s disease... 相似文献
102.
Alexis Joël Graneix Jérémie Balcaen Yannick 《Metallurgical and Materials Transactions A》2021,52(11):5055-5065
Metallurgical and Materials Transactions A - Laser welding is currently a versatile and reliable assembly technique. To save weight in aerostructures and propulsion units and to reduce thermal... 相似文献
103.
Dr. Floriane Gibault Dr. Manon Sturbaut Mathilde Coevoet Dr. Martine Pugnière Dr. Ashley Burtscher Dr. Frédéric Allemand Prof. Patricia Melnyk Prof. Wanjin Hong Prof. Brian P. Rubin Dr. Ajaybabu V. Pobbati Prof. Jean-François Guichou Prof. Philippe Cotelle Dr. Fabrice Bailly 《ChemMedChem》2021,16(18):2823-2844
Starting from our previously reported hit, a series of 1,5-diaryl-1,2,3-triazole-4-carbohydrazones were synthesized and evaluated as inhibitors of the YAP/TAZ-TEAD complex. Their binding to hTEAD2 was confirmed by nanodifferential scanning fluorimetry, and some of the compounds were also found to moderately disrupt the YAP-TEAD interaction, as assessed by a fluorescence polarization assay. A TEAD luciferase gene reporter assay performed in HEK293T cells and RTqPCR measurements in MDA-MB231 cells showed that these compounds inhibit YAP/TAZ-TEAD activity to cells in the micromolar range. In spite of the cytotoxic effects displayed by some of the compounds of this series, they are still good starting points and can be suitably modified into an effective and viable YAP-TEAD disruptor in the future. 相似文献
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Magorzata Prokopowicz Adam Jarmua Yannick Casamayou-Boucau Fiona Gordon Alan Ryder Justyna Sobich Piotr Maj Joanna Ciela Zbigniew Zieliski Piotr Fita Wojciech Rode 《International journal of molecular sciences》2021,22(5)
A homo-dimeric enzyme, thymidylate synthase (TS), has been a long-standing molecular target in chemotherapy. To further elucidate properties and interactions with ligands of wild-type mouse thymidylate synthase (mTS) and its two single mutants, H190A and W103G, spectroscopic and theoretical investigations have been employed. In these mutants, histidine at position 190 and tryptophan at position 103 are substituted with alanine and glycine, respectively. Several emission-based spectroscopy methods used in the paper demonstrate an especially important role for Trp 103 in TS ligands binding. In addition, the Advanced Poisson–Boltzmann Solver (APBS) results show considerable differences in the distribution of electrostatic potential around Trp 103, as compared to distributions observed for all remaining Trp residues in the mTS family of structures. Together, spectroscopic and APBS results reveal a possible interplay between Trp 103 and His190, which contributes to a reduction in enzymatic activity in the case of H190A mutation. Comparison of electrostatic potential for mTS complexes, and their mutants, with the substrate, dUMP, and inhibitors, FdUMP and N-OH-dCMP, suggests its weaker influence on the enzyme–ligand interactions in NOH-dCMP-mTS compared to dUMP-mTS and FdUMP-mTS complexes. This difference may be crucial for the explanation of the ”abortive reaction” inhibitory mechanism of NOH-dCMP towards TS. In addition, based on structural analyses and the H190A mutant capacity to form a denaturation-resistant complex with N-OH-dCMP in the mTHF-dependent reaction, His190 is apparently responsible for a strong preference of the enzyme active center for the anti rotamer of the imino inhibitor form. 相似文献
106.
Bailly François Charbonneau Eve Danès Loane Begon Mickael 《Multibody System Dynamics》2021,52(2):193-209
Multibody System Dynamics - Looking for new arm strategies for better twisting performances during a backward somersault is of interest for the acrobatic sports community while being a complex... 相似文献
107.
Yannick Hermans Andreas Klein Hori Pada Sarker Mohammad N. Huda Henrik Junge Thierry Toupance Wolfram Jaegermann 《Advanced functional materials》2020,30(10)
CuFeO2 is recognized as a potential photocathode for photo(electro)chemical water splitting. However, photocurrents with CuFeO2‐based systems are rather low so far. In order to optimize charge carrier separation and water reduction kinetics, defined CuFeO2/Pt, CuFeO2/Ag, and CuFeO2/NiOx(OH)y heterostructures are made in this work through a photodeposition procedure based on a 2H CuFeO2 hexagonal nanoplatelet shaped powder. However, water splitting performance tests in a closed batch photoreactor show that these heterostructured powders exhibit limited water reduction efficiencies. To test whether Fermi level pinning intrinsically limits the water reduction capacity of CuFeO2, the Fermi level tunability in CuFeO2 is evaluated by creating CuFeO2/ITO and CuFeO2/H2O interfaces and analyzing the electronic and chemical properties of the interfaces through photoelectron spectroscopy. The results indicate that Fermi level pinning at the Fe3+/Fe2+ electron polaron formation level may intrinsically prohibit CuFeO2 from acquiring enough photovoltage to reach the water reduction potential. This result is complemented with density functional theory calculations as well. 相似文献
108.
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110.
Nicolas Bruneau Sylvain Guilley Zakaria Najm Yannick Teglia 《Journal of Cryptology》2018,31(2):351-393
Masking schemes based on tables recomputation are classical countermeasures against high-order side-channel attacks. Still, they are known to be attackable at order d in the case the masking involves d shares. In this work, we mathematically show that an attack of order strictly greater than d can be more successful than an attack at order d. To do so, we leverage the idea presented by Tunstall, Whitnall and Oswald at FSE 2013: We exhibit attacks which exploit the multiple leakages linked to one mask during the recomputation of tables. Specifically, regarding first-order table recomputation, improved by a shuffled execution, we show that there is a window of opportunity, in terms of noise variance, where a novel highly multivariate third-order attack is more efficient than a classical bivariate second-order attack. Moreover, we show on the example of the high-order secure table computation presented by Coron at EUROCRYPT 2014 that the window of opportunity enlarges linearly with the security order d. These results extend that of the CHES ’15 eponymous paper. Here, we also investigate the case of degree one leakage models and formally show that the Hamming weight model is the less favorable to the attacker. Eventually, we validate our attack on a real ATMEL smartcard. 相似文献