An optimal loading principle of burnable poisons for an OTTO refueling scheme in pebble bed HTGR cores

An optimal loading principle of burnable poisons (BPs) is proposed to eliminate the problem of an excessively high power peaking factor in once-through-then-out (OTTO) pebble bed HTGR cores. The effectiveness of the principle is confirmed through neutronic and thermal hydraulic calculations for an HTGR core with thermal power of 600 MWt. Spherical BP particles are distributed uniformly together with TRISO-coated fuel particle inside the free fuel zones of fuel pebbles to maintain constant k_∞ during burnup. The applicability of BP materials, such as B₄C, Gd₂O₃, Sm₂O₃, Eu₂O₃, Er₂O₃, CdO, and HfO₂, is investigated. Because complete BP depletion at the target burnup is required to avoid reactivity loss and extra enrichment, the four BP materials considered as applicable candidates are B₄C, Gd₂O₃, Er₂O₃, and CdO. The complete BP depletion is demonstrated by a burning fraction at the target burnup. The power density is excessively high at the core top and the power peaking factor is 4.44 when no BP is added to the fuel pebbles. Optimal BP loading reduces the power peaking factor from 4.44 to about 1.7. Because of the power peaking factor reduction, the maximum fuel temperatures are lower than the maximum permissible values of 1250 °C for normal operation and 1600 °C during a depressurization accident.     

Biocompatibility of a-C:H film coating for synthetic vascular graft

Amorphous hydrogenated carbon (a-C:H) films have many excellent properties such as biocompatibility, anti-corrosion, and chemical stability. Therefore, there are many reports on application of a-C:H film as surface modification technique for biomaterials. However, it is difficult to deposit a-C:H film on complex structures such as artificial heart blood pump and synthetic vascular grafts. In our previous work, we have developed an electrode which is adapted to such irregular structures for plasma CVD technique.In this study, a-C:H film was deposited on a synthetic vascular graft inner-wall by r.f. plasma CVD technique with cylindrical electrode. The purpose of such coating is improvement of biocompatibility of the vascular graft. The biocompatibility of the a-C:H film was evaluated by cytocompatibility and plasma protein adhesion. For the a-C:H film deposition, cytocompatibility and protein adsorbent of the vascular grafts were improved for biological response under cell culture with mouth fibroblasts and plasma proteins (albumin, fibrinogen, and globulin), respectively. This study indicates that the a-C:H films coatings is expected to surface modification for medical appliances.     

Classification of particles by centrifugal separator and analysis of the fluid behavior

This study gives fundamental knowledge on the particle classification performance by centrifugal separator.It is found that the cut size of a centrifugal separator decreases as the rotational speed increases and the liquid flow rate decreases. Fitting our experimental results with the theory, they agree with each other at high flow rate. However, the difference between them generates at low flow rate. This is because dead spaces are generated in the centrifugal separator at the low flow rate. Also, the computer simulation of the fluid behavior in the centrifugal separator can find the decrease of the velocity near the wall under the low flow rate, which suggests the possibility of the formation of dead spaces in the separator.     

Defect reduction in Cu dual damascene process using short-loop test structures

This paper outlines the defect reduction measures performed during the development of a 130-nm Cu dual-damascene process. The test methodology, using short-loop test structures, included defect tracing, overlaying defect data and electrical measurement data, physical analyses based on these results, and analyses of defect size distribution. While the defect size distributions for large-scale integration processes are considered to depend on x/sup -k/, the distribution for the Cu dual-damascene process is found to be different and is instead characterized by a cumulative distribution described by the composition of several Lorentzian functions. Using these procedures, defect densities were successfully reduced by 50% in half the time taken previously and without the need for actual products.     

cDNA cloning, gene expression and subcellular localization of anthocyanin 5-aromatic acyltransferase from Gentiana triflora

Acylation of anthocyanins with hydroxycinnamic acid derivatives is one of the most important and less under-stood modification reactions during anthocyanin biosynthesis. Anthocyanin aromatic acyltransferase catalyses the transfer of hydroxycinnamic acid moieties from their CoA esters to the glycosyl groups of anthocyanins. A full-length cDNA encoding the anthocyanin 5-aromatic acyltransferase (5AT) (EC 2.3.1.153) that acylates the glucose bound at the 5-position of anthocyanidin 3,5-diglucoside was isolated from petals of Gentiana triflora on the basis of the amino acid sequence of the purified enzyme. The isolated full-length cDNA had an open reading frame of 469 amino acids and the calculated molecular weight was 52,736. The deduced amino acid sequence contains consensus motifs that are conserved among the putative acyl CoA-mediated acyltransferases, and this indicates that 5AT is a member of a proposed superfamily of multi-functional acyltransferases (St-Pierre et al. (1998) Plant J. 14, 703-713). The cDNA was expressed in Escherichia coli and yeast, and confirmed to encode 5AT. The enzymatic characteristics of the recombinant 5AT were consistent with those of the native gentian 5AT. Immunoblot analysis using specific antibodies to 5AT showed that the 5AT protein is present in petals, but not in sepals, stems or leaves of G. triflora. RNA blot analysis showed that the 5AT gene is expressed only in petals and that its expression is temporally regulated during flower development coordinately with other anthocyanin biosynthetic genes. Immunohistochemical analysis demonstrated that the 5AT protein is specifically expressed in the outer epidermal cells of gentian petals and that it is localized mainly in the cytosol.     

Inhibition in a microgravity environment of the recovery of Escherichia coli cells damaged by heavy ion beams during the NASDA ISS phase I program of NASA Shuttle/Mir mission no. 6

OBJECTIVE: To explore whether there are different disease patterns of rheumatoid arthritis (RA) in women and men. METHODS: We studied 55 male case patients and 110 female control patients who developed RA between 1970 and 1985 and who resided and received medical care in Olmsted County, Minnesota, for at least 10 years after the diagnosis of RA. Case and control patients were matched for the date of first diagnosis. The pattern and extent of joint involvement, the frequency of joint surgeries, and the presence and type of extraarticular manifestations were determined by retrospective chart review. RESULTS: Incidence rates in women were variable and age dependent, whereas the risk in men older than 36 years was constant over their lifetime. Erosive disease was more frequent in men than in women (72% versus 55%, respectively; P < 0.05) and tended to occur earlier (47% versus 31% for erosive disease within the first 4 years of RA). Although male sex was correlated with a higher risk of bony erosions and an accelerated course of RA, structural consequences of joint destruction were more pronounced in women. Joint surgery was performed more frequently in women (50%) than in men (27%) (P = 0.01). In particular, the frequencies of arthroplasties and arthrodeses of hand and foot joints were different (34 procedures in women versus 1 procedure in men; P < 0.001). Sex influenced the risk as well as the pattern of organ involvement in RA. Nodules and rheumatoid lung disease were typical manifestations in men (P = 0.001 and P < 0.001, respectively), whereas women typically developed sicca syndrome (P = 0.05). Despite differences in disease aggressiveness and disease pattern, there was little difference in the medical therapy in the men compared with the women. CONCLUSION: RA is a heterogeneous disease with variations in phenotype. Sex-associated factors influence disease severity as well as disease pattern. Because sex-related effects influence treatment goals, treatment responses, and side effects, they should be considered in clinical study design and analysis as well as in the treatment decisions for individual patients with RA.     

A majority-logic device using an irreversible single-electron box

We describe a majority-logic gate device suitable for use in developing single-electron integrated circuits. The device consists of a capacitor array for input summation and an irreversible single-electron box for threshold operation. It accepts three binary inputs and produces a corresponding output, a complementary majority-logic output, by using the change in its tunneling threshold caused by the input signals; it produces a logical 1 output if two or three of the inputs are logical 0 and a logical 0 output if two or three of the inputs are logical 1. We combined several of these gate devices to form subsystems, a shift register and a full adder, and confirmed their operation by computer simulation. The gate device is simple in structure and powerful in terms of implementing digital functions with a small number of devices. These superior features will enable the device to contribute to the development of single-electron integrated circuits.     

沥青混合料劈裂强度与压实度及路用性能相关性研究

为评估15℃劈裂强度作为沥青路面交工验收指标的合理性,选择Sup-13、Sup-20、ATB-25和SMA-13四种沥青混合料,研究15℃劈裂强度与芯样压实度及沥青混合料路用性能的相关性。结果表明,沥青混合料15℃劈裂强度与芯样压实度呈正相关,当压实度为最大理论密度的93%时,Sup-13、Sup-20、SMA-13和ATB-25的劈裂强度分别为1.260MPa、1.423MPa、1.066MPa和1.470MPa。15℃劈裂强度与60℃动稳定度、冻融劈裂强度比和残留稳定度呈正相关,与低温破坏应变呈负相关,相关系数不低于0.6241。