Recent Advances in Application of Computer-Aided Drug Design in Anti-Influenza A Virus Drug Discovery

Influenza A is an acute respiratory infectious disease caused by the influenza A virus, which seriously threatens global human health and causes substantial economic losses every year. With the emergence of new viral strains, anti-influenza drugs remain the most effective treatment for influenza A. Research on traditional, innovative small-molecule drugs faces many challenges, while computer-aided drug design (CADD) offers opportunities for the rapid and effective development of innovative drugs. This literature review describes the general process of CADD, the viral proteins that play an essential role in the life cycle of the influenza A virus and can be used as therapeutic targets for anti-influenza drugs, and examples of drug screening of viral target proteins by applying the CADD approach. Finally, the main limitations of current CADD strategies in anti-influenza drug discovery and the field’s future directions are discussed.     

基于有限样本的大气偏振模式生成方法

大气偏振模式在导航等领域具有广阔的应用前景,但是由于受到大气偏振信息采集装置物理特性的限制,在同一时刻只能获得局部的、不连续的偏振信息,对实际应用产生影响。针对此问题,本文通过挖掘大气偏振模式分布的连续性,提出一种大气偏振模式生成方法,从局部的偏振信息生成全天域的大气偏振模式。此外,偏振信息往往受到不同的天气条件、地理环境等因素的影响,而这些偏振数据在真实环境中难以采集。针对此问题,本文挖掘不同天气、地理条件下有限样本数据之间的多样性关系,以此关系将生成的大气偏振模式泛化到不同的条件下。本论文在仿真数据和实测数据上进行了实验,并与其它最新方法进行对比,实验结果证明了本文方法的优越性和鲁棒性。     

产科护理临床带教中存在的问题及对策

目的:发现产科护理临床带教存在的问题并且提出相应对策,提高带教的质量.方法:对护士带教情况进行调查和分析.结果:产科护理临床带教存在一些急需解决的问题.结论:迫切需要提出一些对策,提高产科护理临床带教的质量.     

提高水旱灾害防御能力 为汉川跨越式发展提供有力保障

湖北省汉川市地处江汉平原腹地,有长江最大支流汉江横贯全境,是一个襟江带湖的平原水网地区;境内地势低洼,河渠纵横,素有＂水袋子＂和＂千里汉江,险在汉川＂之称,是一个洪涝灾害频发的地方。     

An Information Hiding Algorithm Based on Bitmap Resource of Portable Executable File

An information hiding algorithm is proposed, which hides information by embedding secret data into the palette of bitmap resources of portable executable （PE） files. This algorithm has higher security than some traditional ones because of integrating secret data and bitmap resources together. Through analyzing the principle of bitmap resources parsing in an operating system and the layer of resource data in PE files, a safe and useful solution is presented to solve two problems that bitmap resources are incorrectly analyzed and other resources data are confused in the process of data embedding. The feasibility and effectiveness of the proposed algorithm are confirmed through computer experiments.     

Unscented Kalman filtering in the additive noise case

The unscented Kalman filter(UKF) has four implementations in the additive noise case,according to whether the state is augmented with noise vectors and whether a new set of sigma points is redrawn from the predicted state(which is so-called resampling) for the observation prediction.This paper concerns the differences of performances for those implementations,such as accuracy,adaptability,computational complexity,etc.The conditionally equivalent relationships between the augmented and non-augmented unscente...     

中国古代土地所有权问题刍议

中国传统社会是一个农耕社会,土地是社会生活中最主要的物质资源.探讨了中国古代土地所有权存在的基础,认为中国古代土地所有权是一个复合概念,它包含了公权与私权的相互混合,其产生、消灭及其具体内容在本质上表现出一种在国家权力作用下的所有权与他物权的混合性特征.     

液氯汽化工艺的改进

通过对原有液氯汽化工艺的分析,找出了其存在的若干问题,针对这些问题,对液氯汽化工艺进行了改进,提出了液氯热水两级汽化,并应用于生产,取得了可观的经济效益,值得在氯化行业特别是中小企业推广应用。