Fast Li+ Transport via Silica Network-Driven Nanochannels in Ionomer-in-Framework for Lithium Metal Batteries

For the development of all-solid-state lithium metal batteries (LMBs), a high-porous silica aerogel (SA)-reinforced single-Li⁺ conducting nanocomposite polymer electrolyte (NPE) is prepared via two-step selective functionalization. The mesoporous SA is introduced as a mechanical framework for NPE as well as a channel for fast lithium cation migration. Two types of monomers containing weak-binding imide anions and Li⁺ cations are synthesized and used to prepare NPEs, where these monomers are grafted in SA to produce SA-based NPEs (SANPEs) as ionomer-in-framework. This hybrid SANPE exhibits high ionic conductivities (≈10⁻³ S cm⁻¹), high modulus (≈10⁵ Pa), high lithium transference number (0.84), and wide electrochemical window (>4.8 V). The resultant SANPE in the lithium symmetric cell possesses long-term cyclic stability without short-circuiting over 800 h under 0.2 mA cm⁻². Furthermore, the LiFePO₄|SANPE|Li solid-state batteries present a high discharge capacity of 167 mAh g⁻¹ at 0.1 C, good rate capability up to 1 C, wide operating temperatures (from −10 to 40 °C), and a stable cycling performance with 97% capacity retention and 100% coulombic efficiency after 75 cycles at 1 C and 25 °C. The SANPE demonstrates a new design principle for solid-state electrolytes, allowing for a perfect complex between inorganic silica and organic polymer, for high-energy-density LMBs.     

Redox and pH Dual Responsive Polymer Based Nanoparticles for In Vivo Drug Delivery

Responsive nanomaterials have emerged as promising candidates as drug delivery vehicles in order to address biomedical diseases such as cancer. In this work, polymer‐based responsive nanoparticles prepared by a supramolecular approach are loaded with doxorubicin (DOX) for the cancer therapy. The nanoparticles contain disulfide bonds within the polymer network, allowing the release of the DOX payload in a reducing environment within the endoplasm of cancer cells. In addition, the loaded drug can also be released under acidic environment. In vitro anticancer studies using redox and pH dual responsive nanoparticles show excellent performance in inducing cell death and apoptosis. Zebrafish larvae treated with DOX‐loaded nanoparticles exhibit an improved viability as compared with the cases treated with free DOX by the end of a 3 d treatment. Confocal imaging is utilized to provide the daily assessment of tumor size on zebrafish larva models treated with DOX‐loaded nanoparticles, presenting sustainable reduction of tumor. This work demonstrates the development of functional nanoparticles with dual responsive properties for both in vitro and in vivo drug delivery in the cancer therapy.     

A Novel and Facile Route to Synthesize Atomic‐Layered MoS2 Film for Large‐Area Electronics

High‐quality and large‐area molybdenum disulfide (MoS₂) thin film is highly desirable for applications in large‐area electronics. However, there remains a challenge in attaining MoS₂ film of reasonable crystallinity due to the absence of appropriate choice and control of precursors, as well as choice of suitable growth substrates. Herein, a novel and facile route is reported for synthesizing few‐layered MoS₂ film with new precursors via chemical vapor deposition. Prior to growth, an aqueous solution of sodium molybdate as the molybdenum precursor is spun onto the growth substrate and dimethyl disulfide as the liquid sulfur precursor is supplied with a bubbling system during growth. To supplement the limiting effect of Mo (sodium molybdate), a supplementary Mo is supplied by dissolving molybdenum hexacarbonyl (Mo(CO)₆) in the liquid sulfur precursor delivered by the bubbler. By precisely controlling the amounts of precursors and hydrogen flow, full coverage of MoS₂ film is readily achievable in 20 min. Large‐area MoS₂ field effect transistors (FETs) fabricated with a conventional photolithography have a carrier mobility as high as 18.9 cm² V^?1 s^?1, which is the highest reported for bottom‐gated MoS₂‐FETs fabricated via photolithography with an on/off ratio of ≈10⁵ at room temperature.     

Quantitative Proteomics Study Reveals Changes in the Molecular Landscape of Human Embryonic Stem Cells with Impaired Stem Cell Differentiation upon Exposure to Titanium Dioxide Nanoparticles

The increasing number of nanoparticles (NPs) being used in various industries has led to growing concerns of potential hazards that NP exposure can incur on human health. However, its global effects on humans and the underlying mechanisms are not systemically studied. Human embryonic stem cells (hESCs), with the ability to differentiate to any cell types, provide a unique system to assess cellular, developmental, and functional toxicity in vitro within a single system highly relevant to human physiology. Here, the quantitative proteomics approach is adopted to evaluate the molecular consequences of titanium dioxide NPs (TiO₂ NPs) exposure in hESCs. The study identifies ≈328 unique proteins significantly affected by TiO₂ NPs exposure. Proteomics analysis highlights that TiO₂ NPs can induce DNA damage, elevated oxidative stress, apoptotic responses, and cellular differentiation. Furthermore, in vivo analysis demonstrates remarkable reduction in the ability of hESCs in teratoma formation after TiO₂ NPs exposure, suggesting impaired pluripotency. Subsequently, it is found that TiO₂ NPs can disrupt hESC mesoderm differentiation into cardiomyocytes. The study unveils comprehensive changes in the molecular landscape of hESCs by TiO₂ NPs and identifies the impact which TiO₂ NPs can have on the pluripotency and differentiation properties of human stem cells.     

Reduction of false positives in lung nodule detection using a two-level neural classification

The authors have developed a neural-digital computer-aided diagnosis system, based on a parameterized two-level convolution neural network (CNN) architecture and on a special multilabel output encoding procedure. The developed architecture was trained, tested, and evaluated specifically on the problem of diagnosis of lung cancer nodules found on digitized chest radiographs. The system performs automatic "suspect" localization, feature extraction, and diagnosis of a particular pattern-class aimed at a high degree of "true-positive fraction" detection and low "false-positive fraction" detection. In this paper, the authors aim at the presentation of the two-level neural classification method in reducing false-positives in their system. They employed receiver operating characteristics (ROC) method with the area under the ROC curve (A(z)) as the performance index to evaluate all the simulation results. The two-level CNN showed superior performance (A(z)=0.93) to the single-level CNN (A(z)=0.85). The proposed two-level CNN architecture is proven to be promising and to be extensible, problem-independent, and therefore, applicable to other medical or difficult diagnostic tasks in two-dimensional (2-D) image environments.     

Modeling and simulation of powered hip orthosis by pneumatic actuators

In this study, a simulation model for a powered hip orthosis (PHO) with air muscles to predict the gait of paraplegics is presented which can be used as a design tool for hip orthoses. Before simulation, mathematical models for a human dummy with an orthosis and a pneumatic muscle actuator were generated. For the air muscle, coefficients required were obtained by static and dynamic experiments of the air muscle and experiments for the valve controlling the air pressure. The computation was conducted on the ADAMS package together with MATLAB. Computer simulation of the flexion of hip joints by the pneumatic muscle results in similar values to those from gait analysis. With the development of a simulation model for a PHO, the gait simulation model using pneumatic muscles can be used to analyze and evaluate the characteristics and efficiency of a PHO by setting the input and boundary conditions.     

A method to exchange procedurally represented 2D CAD model data using ISO 10303 STEP

Procedural models have the advantage of being easy to edit simply by changing the values of the parameters of their constructional operations. Such models are said to embody design intent, in the sense that modifications to them conform to the method of creation used by their original creator. They also comply with any constraints implied by the particular constructional operations used. This paper introduces the development and standardization process of the ISO 10303-112 specification and describes the concept of procedural 2D modeling, a method of representing procedural 2D CAD models in STEP in harmony with other STEP resources. The feasibility of procedural 2D modeling commands for the exchange of procedurally represented 2D CAD model data is demonstrated through an experiment where procedural 2D CAD model data in neutral form generated with an in-house 2D modeling system are translated to and modified in a commercial 3D mechanical CAD system.     

An enhanced cross-layer fast handover scheme for mobile IPv6 in the IEEE 802.16e networks

The IEEE 802.16e standard enhances the IEEE 802.16 for the mobility support. Mobile stations can move while receiving services, thus ongoing IP sessions may be maintained during a handover in the IEEE 802.16e. To reduce handover latency, the idea of cross-layer handover which incorporates layer 2 handover with IP layer has been devised. Various cross-layer handover schemes supporting fast handover in the IEEE 802.16e networks have been proposed. However, the problem of the conventional cross-layer fast handover schemes is that they are heavily influenced by the new address confirmation latency which is the most time-consuming procedure. In this paper, we propose an enhanced cross-layer fast handover scheme which is not susceptible to the new address confirmation latency. Detailed performance analysis is performed in terms of the signaling costs and the handover latencies to show the effectiveness of the proposed scheme compared with the conventional ones. The results of the performance evaluation confirm the effectiveness of the proposed scheme.     

Sol-Gel Processing and Pyroelectric Properties of Highly Oriented Pb(Mg,Zn)1/3Nb2/3O3 Thin Films

Thin films of Pb(Mg,Zn)_1/3Nb_2/3O₃ (PMZN) were fabricated by spin casting the partially hydrolyzed Pb-Mg-Zn-Nb-O complex alkoxide sols on (111)Pt-coated MgO (100) planes. A strong preferential orientation of (100) perovskite was observed in the thin film derived from the sol exhibiting pseudoplastic behavior. A small-angle X-ray scattering experiment in the Porod region was performed to correlate the observed preferential orientation with the network structure of precursor in the PMZN sol. It was shown that weakly branched precursor systems led to highly oriented perovskite grains after thin-film formation. The highly (100) oriented PMZN film exhibited a larger pyroelectric coefficient (>2 μC/(cm²-K)) and pyroelectric figure-of-merit ( F _D > 4 × 10^1–4 Pa^−1/2) than the PMZN thin film having randomly oriented grains.     

Structure of sol-gel prepared ferroelectric Bi3.4La0.6Ti3O12

The Bi_3.4La_0.6Ti₃O₁₂ (BLT) thin film and powder have been prepared by a sol-gel method with annealing at 700^°C. Randomly oriented BLT thin film exhibits a large remanent polarization, 2P _r = 72 μC/cm², with a dc applied field strength of 320 kV/cm. Structure of sol-gel derived BLT powder has been investigated by neutron scatterings, and refined by a Rietveld method resulting a reasonable goodness of fit (wR _p = 6.7%, and R _p = 5.7%) using an orthorhombic (B2cb, a = 5.4221 Å, b = 5.4032 Å, and c = 32.8361 Å). Two different TiO₆ octahedra exhibit different polarization directions; (100) from Ti(1)O₆, and (011) from Ti(2)O₆, which explains the observed large 2P _r of the randomly oriented BLT thin film.