Optical high-frequency pulse generation with wavelength tunability by using a DBR laser with vernier-type gratings

An optical high-frequency pulse generation method with wavelength tunability is presented by taking advantage of vernier-type gratings in a distributed Bragg reflector laser diode. Experimental results showed that sinusoidal optical pulses, whose lasing wavelengths were tunable, were created with repetition frequencies around 30 GHz. The widths of the radio frequency spectra, furthermore, were drastically reduced by means of mode locking with externally injected optical pulses.     

SORPTION DRYING OF SOYBEAN SEEDS WITH SILICA GEL. I. HYDRODYNAMICS OF A FLUIDIZED BED DRYER

Fluidization technology has been employed to mix soybean seeds and silica gel particles in aim of sorption drying of particulate agricultural products. The characteristic fluidization velocities, mixing mechanisms and fluidization quality have been studied in a 180 mm I.D. fluidized bed. Two sizes of silica gel particles (SG2 and SG3) were selected, with the mass fractions in the range of 0.33-0.75 to form a static bed with height from 100 to 280 mm (H/D = 0.56-1.56). The results show that the dispersion rate of soybean seeds is increased with addition of either SG2 or SG3, and that the frequency and the span of pressure fluctuations within the bed are increased. It is inferred that the gas-solids contacting is improved with addition of small particles in the bed of large particles. In addition, for practical design and operation of such a fluidized bed of binary mixtures, empirical correlations for characteristic fluidization velocities were developed with a wide application.     

Quantitative assessment of cerebral blood flow by 123I-IMP SPECT: venous sampling method with hand warming in the water bath

In order to establish a noninvasive, quantitative method for measuring regional cerebral blood flow (rCBF) by N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) SPECT, we attempted to employ continuous venous sampling instead of arterial sampling. Forty two patients with cerebrovascular diseases were classified into two groups, with (group II: n = 35) and without (group I: n = 7) hand warming. In group II, either hand was warmed, wrapping in a hot blanket (group IIA) or immersed in a 44 degrees C water bath (group IIB). In each patient, immediately after intravenous bolus injection of 222 MBq IMP, arterial and venous blood samples were collected continuously for 5 min from the radial artery and the cubital vein, respectively. By octanol extraction, IMP was divided into the unmetabolized and metabolized fraction. The ratio of 123I-IMP radioactivity of venous blood compared to arterial blood (pass ratio, referred as %PR) was calculated in three fractions, whole blood, unmetabolized, and metabolized fraction. By using these parameters, we assessed the possibility to estimate the amount of unmetabolized IMP fraction of arterial blood, usually used as an input function, from venous samples. In group I, %PR demonstrated a considerable variation between individuals (whole IMP, 47.5 +/- 24.6% (mean +/- SD): unmetabolized IMP, 46.0 +/- 24.5%: metabolized IMP, 51.8 +/- 27.4%). In group II, especially in group IIB, both increase of %PR value and the decrease in variation (whole, 77.9 +/- 5.6%: unmetabolized, 75.7 +/- 5.7%: metabolized, 86.7 +/- 8.7%) were observed, which permitted the further calculation based on the assumption that %PR value was constant in each IMP fraction (whole blood and unmetabolized fraction).(ABSTRACT TRUNCATED AT 250 WORDS)     

THERMAL AND FREEZING STRAINS ON A FACE OF WET SANDSTONE SAMPLES UNDER A SUBZERO TEMPERATURE CYCLE

Some laboratory tests showed rather strange hysteresis loops in strain–temperature space, where the strains were measured with a strain gauge on the surface of a wet cubic rock sample under a subzero temperature cycle. This report gives introductory remarks and the first result on a new project launched by the present authors. The project is intended to make clear the major mechanisms responsible for the unexpected hysteresis loops in the strain–temperature diagram, in which an abrupt increase in strains appeared at a halfway point of the cooling process at higher cooling rates. The hysteresis loops suggest that various thermal and mechanical (or physical) phenomena take place within the rock sample; some possible candidates of causes behind the phenomena are discussed and a hypothesis associated with them is proposed. Furthermore, to separate an unexpected part of the hysteresis loop from its “regular” part, thermal strains on the surface of a spherical sample under a temperature cycle are calculated within the framework of linear thermoelasticity. The equivalence between strains on the surface of a cubic sample and that of a spherical one is discussed.     

Molecular characterization of the PEX5 gene encoding peroxisomal targeting signal 1 receptor from the methylotrophic yeast Pichia methanolica

In this study, we describe the molecular characterization of the PEX5 gene encoding the peroxisomal targeting signal 1 (PTS1) receptor from the methylotrophic yeast Pichia methanolica. The P. methanolica PEX5 (PmPEX5) gene contains a open reading frame corresponding to a gene product of 646 amino acid residues, and its deduced amino acid sequence shows a high similarity to those of Pex5ps from other methylotrophic yeasts. Like other Pex5ps, the PmPex5p possesses seven repeats of the TPR motif in the C-terminal region and three WXXXF/Y motifs. A strain with the disrupted PEX5 gene (pex5Delta) lost its ability to grow on peroxisome-inducible carbon sources, methanol and oleate, but grew normally on glucose and glycerol. Disruption of PmPEX5 caused a drastic decrease in peroxisomal enzyme activities and mislocalization of GFP-PTS1 and some peroxisomal methanol-metabolizing enzymes in the cytosol. Expression of the PmPEX5 gene was regulated by carbon sources, and it was strongly expressed by peroxisome-inducible carbon sources, especially methanol. Taken together, these findings show that PmPex5p has an essential physiological role in peroxisomal metabolism of P. methanolica, including methanol metabolism, and in peroxisomal localization and activation of methanol-metabolizing enzymes, e.g. AOD isozymes, DHAS and CTA.     

Antihypertensive activity of peptides identified in the in vitro gastrointestinal digest of pork meat

This study investigated the in vivo antihypertensive activity of three novel peptides identified in the in vitro digest of pork meat. These peptides were RPR, KAPVA and PTPVP and all of them showed significant antihypertensive activity after oral administration to spontaneously hypertensive rats, RPR being the peptide with the greatest in vivo activity. To our knowledge, this is the first report showing the in vivo antihypertensive action of the three peptides from nebulin (RPR) and titin (KAPVA and PTPVP), thus confirming their reported in vitro angiotensin I-converting enzyme (ACE) inhibitory activity. These findings suggest that pork meat could constitute a source of bioactive constituents that could be utilized in functional foods or nutraceuticals.     

In vitro and in vivo anti-Staphylococcus aureus activities of a new disinfection system utilizing photolysis of hydrogen peroxide

The present study aimed to evaluate in vitro and in vivo antibacterial activity of hydroxyl radical generation system by photolysis of H(2)O(2), which is a new disinfection system for the treatment of oral infection diseases such as periodontitis developed in our laboratory. Firstly, generation of the hydroxyl radical by the photolysis of H(2)O(2) in which 1 mol l(-1) H(2)O(2) was irradiated with a dual wavelength-light emitting diode (LED) at wavelengths of 400 and 465 nm was confirmed by applying an electron spin resonance-spin trapping technique. Secondly, the bactericidal effect of the system was examined under a similar condition in which Staphylococcus aureus suspended in 1 mol l(-1) H(2)O(2) was irradiated with LED light, resulting in substantial reduction of the colony forming unit (CFU) of the bacteria within a short time as 2 min. Finally, in vivo antibacterial effect of the photolysis of H(2)O(2) on a rat model of S. aureus infection was evaluated by a culture study. Since a significant reduction of recovered CFU of S. aureus was obtained, it is expected that in vitro antibacterial effect attributable to hydroxyl radicals generated by photolysis of H(2)O(2) could be well reflected in in vivo superficial bacterial infection.     

Characteristics of combined heat transfer of superheated steam drying: Numerical study on coupled convection and gas radiation heat transfer

A numerical study on a combined radiation and forced convection heat transfer of superheated steam, which is a radiation participating real gas, in thermally developing laminar flow through a parallel‐plate channel has been conducted to investigate characteristics of superheated steam drying. The integrodifferential energy equation was solved using an implicit finite‐difference technique with a marching solution procedure and an exponential wide‐band model for the treatment of the radiative transfer part. Comparison of results with and without gas radiation in various conditions shows that fluid radiation decreases the temperature of the main stream, but increases the total heat flux at a heat transfer surface. Furthermore, the results show that the fluid radiation decreases the inversion point temperature approximately to 150 to 240 °C with the increase of optical thickness. This numerical result agrees in an order of magnitude with the previous experimental studies, but is about 100 K lower than that of former theoretical predictions without considering fluid radiation. © 2000 Scripta Technica, Heat Trans Asian Res, 29(5): 385–399, 2000