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排序方式: 共有920条查询结果,搜索用时 15 毫秒
911.
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913.
This paper presents an interactive system for realistic visualization of earth-scale clouds. Realistic images can be generated at interactive frame rates while the viewpoint and the sunlight directions can be changed interactively. The realistic display of earth-scale clouds requires us to render large volume data representing the density distribution of the clouds. However, this is generally time-consuming and it is difficult to achieve the interactive performance, especially when the sunlight direction ca... 相似文献
914.
Yoshinori Hamamoto K.C. Amanul Alam Atsushi Akisawa Takao Kashiwagi 《International Journal of Refrigeration》2005,28(3):1704
The performance of a two-stage adsorption chiller with different mass allocation between upper and bottom beds has been investigated numerically. It is found that the chiller can be driven effectively by the waste heat of temperature 55 °C with the heat sink at environment temperature. Results show that cooling capacity can be improved with the optimum allocation of adsorbent mass to the bottom beds than that to the upper beds. The improvement in Coefficient of Performance (COP) values, however, is less significant. It is also seen that the improvement in cooling capacity is more significant for the relatively higher heat source temperature. It is shown that the cooling capacity can be improved up to 20% if the heat source temperature is 80 °C and the average outlet temperature is fixed at 7 °C. 相似文献
915.
When or whether elderly drivers stop driving is concerning not only to the drivers themselves but also to their family members. Therefore, it is important for family members to take the initiative if they wish to obtain information on the likelihood of the drivers’ involvement in crashes. On the basis of the older drivers’ Everyday Behavior Questionnaire (EBQ) developed in this paper, we attempt to predict drivers’ involvement in crashes using the responses given by their family members. The results revealed that this 14-item questionnaire has a sufficient level of internal consistency as well as a significant correlation (r = 0.29) with the experience of involvement in crashes in the last three years (p < 0.01). Although the EBQ is a proxy-reported questionnaire and does not include items directly related to driving behaviors, the correlation between the EBQ and crash involvement is stronger than that of the self-reported Driver Behavior Questionnaire reported in deWinter and Dodou (2010), who conducted a meta-analysis and estimated the overall correlation among samples of earlier studies. In addition, logistic regression analysis showed that the EBQ score and the exposure to driving risks, measured by the frequency of driving, are significant predictors of involvement in crashes. 相似文献
916.
Yuki Tada Kaichi Kasai Nana Makiuchi Naoya Igarashi Koudai Kani Shun Takano Hiroe Honda Tsutomu Yanagibashi Yasuharu Watanabe Fumitake Usui-Kawanishi Yukihiro Furusawa Mayuko Ichimura-Shimizu Yoshiaki Tabuchi Kiyoshi Takatsu Koichi Tsuneyama Yoshinori Nagai 《International journal of molecular sciences》2022,23(21)
Macrophages play critical roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). However, it is unclear which macrophage subsets are critically involved in the development of inflammation and fibrosis in NASH. In TSNO mice fed a high-fat/cholesterol/cholate-based diet, which exhibit advanced liver fibrosis that mimics human NASH, we found that Kupffer cells (KCs) were less abundant and recruited macrophages were more abundant, forming hepatic crown-like structures (hCLS) in the liver. The recruited macrophages comprised two subsets: CD11c+/Ly6C− and CD11c−/Ly6C+ cells. CD11c+ cells were present in a mesh-like pattern around the lipid droplets, constituting the hCLS. In addition, CD11c+ cells colocalized with collagen fibers, suggesting that this subset of recruited macrophages might promote advanced liver fibrosis. In contrast, Ly6C+ cells were present in doughnut-like inflammatory lesions, with a lipid droplet in the center. Finally, RNA sequence analysis indicates that CD11c+/Ly6C− cells promote liver fibrosis and hepatic stellate cell (HSC) activation, whereas CD11c−/Ly6C+ cells are a macrophage subset that play an anti-inflammatory role and promote tissue repair in NASH. Taken together, our data revealed changes in liver macrophage subsets during the development of NASH and shed light on the roles of the recruited macrophages in the pathogenesis of advanced fibrosis in NASH. 相似文献
917.
918.
Dr. Riku Kawasaki Hidetoshi Hirano Keita Yamana Ayano Oshige Kotaro Nishimura Nanami Kono Dr. Yu Sanada Kaori Bando Anri Tabata Naoki Yasukawa Dr. Hideki Azuma Takushi Takata Dr. Yoshinori Sakurai Prof. Hiroki Tanaka Prof. Minoru Suzuki Dr. Naoki Tarutani Prof. Kiyofumi Katagiri Prof. Takeshi Nagasaki Prof. Atsushi Ikeda 《Chembiochem : a European journal of chemical biology》2023,24(15):e202300186
Minimally invasive boron neutron capture therapy (BNCT) is an elegant approach for cancer treatment. The highly selective and efficient deliverability of boron agents to cancer cells is the key to maximizing the therapeutic benefits of BNCT. In addition, enhancement of the frequencies to achieve boron neutron capture reaction is also significant in improving therapeutic efficacy by providing a highly concentrated boron agent in each boron nanoparticle. As the density of the thermal neutron beam remains low, it is unable to induce high-efficiency cell destruction. Herein, we report phospholipid-coated boronic oxide nanoparticles as agents for BNCT that can provide a highly concentrated boron atom in each nanoparticle. The current system exhibited in vitro BNCT activity seven times higher than that of commercial boron agents. Furthermore, the system could penetrate cancer spheroids deeply, efficiently suppressing thermal neutron irradiation-induced growth. 相似文献
919.
Lydia H. Zhang Michelle Tang Xavier Tao Qian Shao Vienna Thomas Saki Shimizu Miki Kasano Yoshinori Ishikawa Takayuki Inukai Prof. Daniel K. Nomura 《Chembiochem : a European journal of chemical biology》2023,24(23):e202300371
Dysregulated oxidative stress plays a major role in cancer pathogenesis and some types of cancer cells are particularly vulnerable to inhibition of their cellular antioxidant capacity. Glutamate-cysteine ligase (GCL) is the first and rate-limiting step in the synthesis of the major cellular antioxidant glutathione (GSH). Developing a GCL inhibitor may be an attractive therapeutic strategy for certain cancer types that are particularly sensitive to oxidative stress. In this study, we reveal a cysteine-reactive ligand, EN25, that covalently targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL, and leads to inhibition of GCL activity. This interaction also leads to reduced cellular GSH levels and impaired cell viability in ARID1A-deficient cancer cells, which are particularly vulnerable to glutathione depletion, but not in ARID1A-positive cancer cells. Our studies uncover a novel potential ligandable site within GCLM that can be targeted to inhibit GSH synthesis in vulnerable cancer cell types. 相似文献
920.
Ayu Nakagawa Hirotoshi Nakabayashi Yoshinori Nishiwaki Shuhei Ogo Tadaharu Ueda Takuya Hasegawa 《Journal of the American Ceramic Society》2023,106(2):1149-1158
Ca14Al10Zn6O35:Mn4+ (CAZ:Mn) phosphor material, which shows deep-red luminescence, was synthesized by the coprecipitation (COP) method using a Na2CO3/NaOH solution as the precipitant. COP–CAZ:Mn phosphor exhibited a 2.1 times higher luminescence intensity than the corresponding phosphor prepared using the conventional solid-state reaction (SSR) method. This substantial increase in luminescence was mainly ascribed to the existence of a greater proportion of tetravalent manganese in COP–CAZ:Mn phosphor. Furthermore, COP–CAZ:Mn phosphor was modified with SiO2 via hydrolysis of tetraethoxysilane (TEOS) to waterproof the compound because it is easily decomposed through hydrolysis under humid conditions. The SiO2-modified CAZ:Mn phosphor maintained its crystal structure and high photoluminescence intensity after the water-resistance test. Therefore, waterproof CAZ:Mn phosphor with a high luminescence intensity was successfully discovered by utilizing the coprecipitation method and SiO2 modification. 相似文献