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排序方式: 共有1692条查询结果,搜索用时 15 毫秒
41.
Jannatul Aklima Sawaros Onchaiya Tomonori Saotome Punitha Velmurugan Taihei Motoichi Jannatul Naima Yutaka Kuroda Yoshihiro Ohta 《International journal of molecular sciences》2022,23(17)
Protein quality control is essential for cellular homeostasis. In this study, we examined the effect of improperly folded proteins that do not form amyloid fibrils on mitochondria, which play important roles in ATP production and cell death. First, we prepared domain 3 of the dengue envelope protein in wild type and four mutants with widely different biophysical properties in misfolded/aggregated or destabilized states. The effects of the different proteins were detected using fluorescence microscopy and Western blotting, which revealed that three of the five proteins disrupted both inner and outer membrane integrity, while the other two proteins, including the wild type, did not. Next, we examined the common characteristics of the proteins that displayed toxicity against mitochondria by measuring oligomer size, molten globule-like properties, and thermal stability. The common feature of all three toxic proteins was thermal instability. Therefore, our data strongly suggest that thermally unstable proteins generated in the cytosol can cause cellular damage by coming into direct contact with mitochondria. More importantly, we revealed that this damage is not amyloid-specific. 相似文献
42.
Tomohiro Fujii Jun Nishikawa Soichiro Fukuda Naoto Kubota Junzo Nojima Koichi Fujisawa Ryo Ogawa Atsushi Goto Koichi Hamabe Shinichi Hashimoto Aung Phyo Wai Hisashi Iizasa Hironori Yoshiyama Kohei Sakai Yutaka Suehiro Takahiro Yamasaki Taro Takami 《International journal of molecular sciences》2022,23(18)
DNA methylation of both viral and host DNA is one of the major mechanisms involved in the development of Epstein–Barr virus-associated gastric carcinoma (EBVaGC); thus, epigenetic treatment using demethylating agents would seem to be promising. We have verified the effect of , which was discovered by screening for demethylating agents. MC180295 inhibited cell growth of the EBVaGC cell lines YCCEL1 and SNU719 in a dose-dependent manner. In a cell cycle analysis, growth arrest and apoptosis were observed in both YCCEL1 and SNU719 cells treated with MC180295. MKN28 cells infected with EBV were sensitive to MC180295 and showed more significant inhibition of cell growth compared to controls without EBV infection. Serial analysis of gene expression analysis showed the expression of genes belonging to the role of BRCA1 in DNA damage response and cell cycle control chromosomal replication to be significantly reduced after MC180295 treatment. We confirmed with quantitative PCR that the expression levels of BRCA2, FANCM, RAD51, TOP2A, and CDC45 were significantly decreased by MC180295. LMP1 and BZLF1 are EBV genes with expression that is epigenetically regulated, and MC180295 could up-regulate their expression. In conclusion, MC180295 inhibited the growth of EBVaGC cells by suppressing DNA repair and the cell cycle. MC180295相似文献
43.
To create a character animation, a 3D character model is often needed. However, since humanlike characters are not rigid bodies, to deform the character model to fit each animation frame is tedious work. Therefore, we propose an easy-to-use method for creating a set of consistent 3D character models from some hand-drawn sketches while keeping the projected silhouettes and features of the created models consistent with the input sketches. Since the character models possess vertexwise correspondences, they can be used for frame-consistent texture mapping or for making character animations. In our system, the user only needs to annotate the correspondence of the features among the input-vector-based sketches; the remaining processes are all performed automatically. 相似文献
44.
Shiomi N Yamaguchi Y Nakai H Fujita T Katsuda T Katoh S 《Journal of Bioscience and Bioengineering》2006,102(3):206-209
The rates of degradation of cyanuric acid, a key intermediate in a metabolic pathway of s-triazine herbicides, were measured for Pseudomonas sp. NRRL B-12227. The rate of degradation was affected by the rate of cyanuric acid transport through cell membranes and the activity of cyanuric acid amidohydrolase inside the cells. At low concentrations of cyanuric acid, the acclimation of cells to cyanuric acid and/or added nutrients effectively enhanced the degradation rate. The strain was also applied to bioremediation using a Bioremediation with Self-Immobilization System (BSIS), in which Pseudomonas sp. NRRL B-12227 cells were co-immobilized with Bacillus subtilis, the latter of which secretes a viscous polymer, in a shallow layer of soil packed in a column. More than 70% of the Pseudomonas sp. NRRL B-12227 cells were co-immobilized with the B. subtilis in a 7.5 cm layer of the packed soil by self-aggregation. More than 60% of the 1 mM cyanuric acid supplied to the packed soil was degraded in this layer during a 72 h period. 相似文献
45.
46.
Naoki Horiguchi Hiroyuki Yoshida Yutaka Abe 《Journal of Nuclear Science and Technology》2019,56(3):278-290
Venturi scrubbers for filtered venting have been installed in nuclear power plants worldwide. Venturi scrubbers can eliminate fission products from a polluted gas by interaction through gas–liquid interfaces. Therefore, droplet diameter is important from the viewpoint of decontamination. When Venturi scrubbers are used in severe accidents, the gas flow velocity might be extremely high. In these studies, the authors did not measure droplet diameter under extremely high gas velocity conditions. In the scenarios, experimental data pertaining to droplet diameter, under the extremely high gas flow velocity, are required. Therefore, this objective is to evaluate the diameter of extremely high-speed droplets. A visualization experiment was conducted using a Venturi scrubber. The droplet diameter distribution and the Sauter mean diameter (SMD) were determined. By comparing between the experimental value of SMDs and the one evaluated using Nukiyama–Tanasawa equation, it was confirmed that the Nukiyama–Tanasawa equation can be used to evaluate SMD with good accuracy in the gas velocity range of 82–250 m/s, except the highest gas velocity conditions. Furthermore, the droplet generation mechanism in the Venturi scrubber was considered to clarify the main reason why the Nukiyama–Tanasawa equation can be used to evaluate SMD droplet diameter. 相似文献
47.
48.
Voltage Control of Static Var Compensator for a Remote System Interconnected by Long‐Distance AC Cables 下载免费PDF全文
Yuji Tamura Shinji Takasaki Yasuyuki Miyazaki Hideo Takeda Shoichi Irokawa Kikuo Takagi Naoto Nagaoka 《Electrical Engineering in Japan》2014,186(3):19-30
The voltage variation in a remote system is large when the system is connected by long‐distance AC cables due to the cable capacitance. In Japan, the longest 54‐km 66‐kV AC submarine cable interconnection between the Kyushu mainland and Goto Islands was commissioned in 2005. It was requested to mitigate the voltage variation caused by switching off and on one circuit of the two circuits in the AC cables when a fault occurs. Since the conventional voltage control methods such as transformer tap changer or shunt capacitor and reactor banks are not sufficient because of their slow response time, a static var compensator (SVC) was installed on the Goto Islands. In such an application, an SVC control method should be developed so as not to override the existing voltage control systems. This paper describes the SVC control method developed for the Goto Islands AC interconnection project, which can be applied to similar situations. The effectiveness of the control method was verified by the results of effective value simulation and of field testing, which was implemented before the SVC was commissioned in 2007. © 2013 Wiley Periodicals, Inc. Electr Eng Jpn, 186(3): 19–30, 2014; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/eej.22337 相似文献
49.
Yutaka Kawahara Atsushi Nakayama Masatoshi Shioya Masaki Tsuji Hideki Yamane Tadahisa Iwata 《Journal of Materials Science》2012,47(4):1887-1892
Structure of poly(dioxanone) (PPDX) fibers produced through a two-step melt-spinning process with an additional short-period
annealing above the melting temperature of PPDX was investigated and the effect of annealing on the degradation behavior was
discussed. The morphological study carried out by etching the fibers using a phosphate or permanganate solution suggested
that the fibers take a skin–core structure, and both the skin layer and the core region consist of a bundle of microfibrils.
The micro-beam X-ray diffraction analysis revealed that the short-period annealing in the production process only slightly
promotes the crystallization in the skin layer but contributes to increasing the packing of amorphous chains near the skin,
which seems to be the controlling factor of the hydrolytic degradation behavior of the fibers. 相似文献
50.
Yosuke Ue Ryoichi Hara Hiroyuki Kita Yutaka Saito Katsuyuki Takitani Masami Saito 《Electrical Engineering in Japan》2012,180(3):55-63
Photovoltaic (PV) systems are attracting attention as one of the promising countermeasures against global warming and the environmental issues. However, the generation output from PV systems is generally unstable and unpredictable. Therefore, large penetration of PV systems may cause some serious impacts on power system operation, such as load frequency control, voltage regulation, etc. Estimation of the influences of PV system installation is becoming important, but it requires simultaneous multipoint solar radiation measurements. The Japan Meteorological Business Support Center has provided 1‐minute meteorological data observed in Japan, but its solar radiation data includes quantization errors. This paper proposes a regeneration method for solar radiation data including quantization errors. It also analyzes the spatial smoothing effect of global solar radiation fluctuations. © 2012 Wiley Periodicals, Inc. Electr Eng Jpn, 180(3): 55–63, 2012; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/eej.21274 相似文献