全文获取类型
收费全文 | 100527篇 |
免费 | 8055篇 |
国内免费 | 4263篇 |
专业分类
电工技术 | 5610篇 |
技术理论 | 6篇 |
综合类 | 6248篇 |
化学工业 | 16550篇 |
金属工艺 | 6150篇 |
机械仪表 | 6952篇 |
建筑科学 | 8066篇 |
矿业工程 | 3403篇 |
能源动力 | 2905篇 |
轻工业 | 6275篇 |
水利工程 | 1658篇 |
石油天然气 | 7330篇 |
武器工业 | 805篇 |
无线电 | 10690篇 |
一般工业技术 | 11553篇 |
冶金工业 | 6020篇 |
原子能技术 | 1010篇 |
自动化技术 | 11614篇 |
出版年
2024年 | 449篇 |
2023年 | 1772篇 |
2022年 | 3114篇 |
2021年 | 4250篇 |
2020年 | 3313篇 |
2019年 | 2692篇 |
2018年 | 2907篇 |
2017年 | 3283篇 |
2016年 | 3038篇 |
2015年 | 4104篇 |
2014年 | 4901篇 |
2013年 | 5834篇 |
2012年 | 6297篇 |
2011年 | 6724篇 |
2010年 | 5769篇 |
2009年 | 5509篇 |
2008年 | 5363篇 |
2007年 | 5080篇 |
2006年 | 5409篇 |
2005年 | 4710篇 |
2004年 | 2990篇 |
2003年 | 2832篇 |
2002年 | 2657篇 |
2001年 | 2414篇 |
2000年 | 2328篇 |
1999年 | 2679篇 |
1998年 | 2403篇 |
1997年 | 1959篇 |
1996年 | 1824篇 |
1995年 | 1474篇 |
1994年 | 1210篇 |
1993年 | 808篇 |
1992年 | 653篇 |
1991年 | 453篇 |
1990年 | 364篇 |
1989年 | 313篇 |
1988年 | 241篇 |
1987年 | 155篇 |
1986年 | 134篇 |
1985年 | 83篇 |
1984年 | 53篇 |
1983年 | 48篇 |
1982年 | 50篇 |
1981年 | 40篇 |
1980年 | 31篇 |
1979年 | 16篇 |
1978年 | 4篇 |
1977年 | 33篇 |
1976年 | 70篇 |
1975年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
This paper studies a Kansas Department of Transportation welded plate girder bridge that developed fatigue cracks at small web gaps close to the girder top flange. Repair had been previously performed by softening the connection plate end with a slot retrofit, but cracks were recently found to have reinitiated at some of the repaired details and are again propagating. A comprehensive finite-element method study was performed to investigate the cracking behavior observed in the bridge and to recommend appropriate measures for future bridge retrofit. The analytical results show that stresses developed at the top flange web gaps could exceed yielding under the loading of an HS15 fatigue truck. The current slot repair used in the bridge was found to have introduced higher magnitude fatigue stresses in the web gap. To achieve a permanent repair of the bridge, it is recommended that a welded connection plate to flange attachment be used during future bridge retrofit. The web gap details should be able to withstand unlimited number of load cycles once this additional repair is performed. 相似文献
52.
53.
Miao Wang Xinluo Zhao Masato Ohkohchi Yoshinori Ando 《Fullerenes, Nanotubes and Carbon Nanostructures》1996,4(5):1027-1039
Carbon nanotubes prepared by de arc discharge of graphite electrodes in He and CH4 gas took markedly different morphology. Thick nanotubes embellished with many carbon nanoparticles were obtained by evaporation under high CH4 gas pressure and high arc current. Thin and long carbon nanotubes were obtained under a CH4 gas pressure of 50Torr and an arc current of 20A for the anode with a diameter of 6mm. 相似文献
54.
The iron status of 22 children and adolescents with Crohn's disease (mean age: 13 years) was evaluated. Eleven patients were suffering from active disease with inflammation, identified by at least one abnormal value for serum orosomucoid, C-reactive protein or sedimentation rate (group I). Eleven patients were in clinical remission and showed no biological evidence of inflammation (group II). Hemoglobin and red cell indices, erythrocyte protoporphyrin, serum iron, transferrin, serum ferritin and basic red cell ferritin were determined in all patients. The usual indicators of iron status, particularly serum ferritin, were affected by the inflammatory processes, but basic red cell ferritin appeared to be independent of inflammation. Basic red cell ferritin can therefore be considered to be a reliable indicator of iron status in children and adolescents with Crohn's disease. 相似文献
55.
DF Muir 《Canadian Metallurgical Quarterly》1997,4(4):292-303
Tumor development and progression in the nervous system are poorly understood. Consequently, even though there seems to be little possibility of major advances in existing clinical modalities used to treat malignant brain tumors, no targeted molecular therapies have risen to take their place. The variability and plasticity of brain neoplasms make them an illusive target for study and therapeutic intervention. Further complicated by infiltration of vital nervous tissue, clinical studies have serious practical limitations and the ability to assess tumor progression in vivo is still a developing technology. Evaluation of potential new therapies for brain tumors is heavily dependent on the development of more informative and cognate experimental models. To develop and validate new models, it is particularly important to integrate clinical, pathological, and cell biological characterizations of malignant brain tumors. This discussion provides an overview of developments in tumor cell culture and the impact of animal models on brain tumor research. Studies of malignant glial neoplasms associated with a dismal prognosis in patients receive particular attention. 相似文献
56.
WC对Cu/WC_P复合材料性能及组织的影响 总被引:8,自引:0,他引:8
通过WC含量对WC/Cu复合材料性能的影响,确定了冷压-烧结法制备Cu/WC材料的适宜WC含量为10vol%左右。并就WC对该材料组织和再结晶行为的影响进行了有益的探讨。 相似文献
57.
从油田现场反应的情况出发,对调整井固井,尾管固井,大位移井套管固井和其他固井的质量问题进行了分析,针对各种问题产生的原因,提出了相应换解决办法。 相似文献
58.
SM Kornblau E Estey T Madden HT Tran S Zhao U Consoli V Snell G Sanchez-Williams H Kantarjian M Keating RA Newman M Andreeff 《Canadian Metallurgical Quarterly》1997,15(5):1796-1802
PURPOSE: Expression of the multidrug resistance gene (MDR1) p170 protein is frequent in leukemic blasts from patients with relapsed acute myelogenous leukemia (AML). A phase I study using the nonimmunosuppressive MDR1 blocker SDZ PSC-833 (PSC) in combination with mitoxantrone (MITO) and etoposide (VP) was performed. PATIENTS AND METHODS: Starting doses (LVL0) of MITO (3.25 mg/m2/d on days 1 and 3 to 6) and VP (210 mg/m2/d on days 1 and 3 to 5) were 40% of the maximal-tolerated dose (MTD) from a prior study. A 1.5-mg/kg loading dose of PSC was followed by a 120-hour continuous infusion of 10 mg/kg/d on days 2 to 6. Blood samples for PSC, MITO, and VP pharmacokinetics (PK) were taken on days 1 and 3, and samples for MDR1 expression were taken on day 0. RESULTS: Severe mucositis developed in all patients at LVL0; therefore, MITO and VP doses were reduced to 2.5 and 170 mg/m2 (LVL-1) for the next seven patients, and this dose proved to be MTD. All LVL0 and three LVL-1 patients had transient elevations in the serum bilirubin level to > or = 4 mg/dL. Serum creatinine level increased to greater than 2 mg/dL in one case. There were no other grade 3 or 4 nonhematologic toxicities observed. The peripheral blood was cleared of leukemia in three LVL0 and four LVL-1 patients. The marrow was cleared of leukemic cells in one LVL0 and five LVL-1 patients, and a significant reduction in marrow leukemic infiltrate was observed in eight of 10. No patient achieved complete remission (CR), and all died of progressive disease (n = 8) or infection (n = 2). MDR1 expression was detected by fluorescent-activated cell sorter (FACS) analysis in five of seven cases. An elevated MDR1 mRNA level was detected by quantitative polymerase chain reaction (Q-PCR) in six of eight cases studied. Clearing of leukemia cells from the marrow occurred in four of six MDR1-positive and one of three MDR1-negative patients. Despite the fact that LVL0 doses had to be reduced due to toxicity, coadministration of PSC did not produce a consistent effect on MITO PK; however, it did repeatedly lead to increased levels of VP in the serum. CONCLUSION: We conclude that PSC-MITO-VP is a tolerable regimen with antileukemic activity. Addition of PSC necessitated a 66% reduction in MITO and VP doses from a prior study without PSC. 相似文献
59.
60.
L Bini B Magi B Marzocchi F Arcuri S Tripodi M Cintorino JC Sanchez S Frutiger G Hughes V Pallini DF Hochstrasser P Tosi 《Canadian Metallurgical Quarterly》1997,18(15):2832-2841
Reference two-dimensional (2-D) gels are presented for human breast ductal carcinoma and histologically normal tissue. Whole biopsy fragments were analyzed, including epithelial and nonepithelial components. Thirty-five spots have been assigned by gel matching to the human liver SWISS-2DPAGE reference map and/or to the human primary keratinocyte IPG map from the Danish Center for Human Genome. N-terminal microsequencing was applied to confirm randomly chosen matching assignments and to identify six new spots. Protein expression profiles in ductal carcinoma and in normal breast tissue appeared to be similar, except for a pattern consisting of 32 spots, which were highly expressed in all carcinoma specimens, and less intense and occasionally undetectable in normal tissue. This difference was statistically significant. Assignment has been obtained for several spots, namely GRP94, GRP78, GRP75, mitochondrial HSP60, calreticulin, protein disulfide isomerase, peptidyl-prolyl cis-trans isomerase, collagen-binding protein 2, fructose bisphosphate aldolase, glyceraldehyde-3-phosphate dehydrogenase, thioredoxin, cytochrome c oxidase VA subunit, tubulin beta isoform and macrophage migration inhibitory factor (MIF). The cancer- and tissue-specificity of the described pattern was assessed by matching to the Swiss-2DPAGE human liver, hepatoma, lymphoma, erythroleukemia reference maps. The pattern of 32 spots was found to be indicative of epithelial neoplasia. 相似文献