Preparation and Characterization of Carboxymethyl Chitosan and β-Cyclodextrin Microspheres by Spray Drying

Three kinds of carboxymethyl chitosan/β-cyclodextrin microspheres loaded with theophylline were prepared by spray drying intended for pulmonary delivery. Mucociliotoxicity, permeation rate, and drug release characteristics of the product were investigated. The microspheres obtained by spray drying were found to be spherical with smooth or wrinkled surfaces. The mean particle size was between 3.39 and 6.06 µm. The microspheres demonstrated high product yield (43.7-50.2%), high drug loading (13.7-38.1%), and high encapsulation efficiency (86.9-92.8%). FT-IR indicated that there were interactions of theophylline with carboxymethyl chitosan matrix. Further studies on mucociliotoxicity and permeation confirmed that microspheres had better adaptability and high permeation rate. In vitro drug release from the microspheres was not related to the drug/polymer ratios.     

关于传统与现代设计理念的思考

中国传统的思维方式深深地影响了中国传统陶瓷艺术设计，中国传统陶瓷艺术设计的历史脉络清晰，深入到设计思维系统的深层，才有助于我们对当前的陶瓷设计作出有效的转化。现代陶瓷设计的观念是对传统陶瓷文化的延续和发展，深入挖掘传统思维方式的源头活水，才是发展中国现代陶瓷设计的关键。     

提高E^2PROM中NMOS管源漏穿通电压的实验研究

为了提高Ｅ＾２ＰＲＯＭ中Ｎ管源漏穿通电压，用实验的方法对制造工艺进行了研究。结果表明，高能量注入是提高ＶＰＴ的有效手段，但受到ｐｎ结击穿的限制，只适用于低区短沟Ｎ管；ＤＤＤ工艺大幅度高ＶＰＴ，但ｐｎ结击穿电压低于２０Ｖ，不能应用于高压ＭＯＳ管；采用适量的防穿通注入和适当增大沟道长度为最理想的工艺途径。     

数字化战场的技术体系结构

阐述了信息制胜战中数字战场的三种体系结构（作战体系结构、系统体制结构与技术体系结构）及信息系统技术体系近几年的发展；介绍了信息化战场提出的几种技术体系结构，进而分析指出了数字化战场发展过程中所需要开发的各种信息业务和应当注意加强研究的技术方面。     

The Synthesis of Covalent Triazine-Based Frameworks via Friedel–Crafts Reactions of Cyanuric Chloride with Thienyl and Carbazolyl Derivatives for Fluorescence Sensing to Picric Acid,Iodine and Capturing Iodine

A multifunctional thiophene-based covalent triazine framework (TTPATTh) with triphenylamine as core is synthesized by Friedel–Crafts reaction of cyanuric chloride with thienyl derivative for the first time. The yield of TTPATTh (99.59%) is far higher than that of the carbazole-based CTF (TTPATCz, 47.03%). TTPATTh and TTPATCz possess high BET surface areas with 1235 and 2501 m² g^–1 as well as high pore volumes with 1.60 and 2.23 cm³ g^–1, respectively. TTPATTh and TTPATCz have high thermal stability with high thermal decomposition temperatures of 514 and 598 °C in nitrogen atmosphere. With the introduction of triazine rings, the fluorescence sensing sensitivities of TTPATTh and TTPATCz to picric acid and iodine are improved significantly. Especially for TTPATTh, the K_sv values reach 5.95 × 10⁵ and 1.61 × 10⁴ L mol^–1, and LODs reach 1.02 × 10^–12 and 1.86 × 10^–12 mol L^–1. To the best of the knowledge, this is the most sensitive value among thiophene-based porous organic polymers to PA and I₂. Furthermore, TTPATTh and TTPATCz can also adsorb iodine in vapor phase, cyclohexane solution and aqueous solution, and release iodine by heating or in ethanol solution. The efficiency of controlling the release of iodine is higher than that in ethanol.     

免疫遗传算法在烧结矿配料优化中的应用

运用免疫遗传算法和MATLAB语言 ,编制了钢铁烧结矿配料优化计算仿真程序 ,计算机仿真结果表明符合实际生产工艺要求 ,可直接应用于生产 ,提高各种烧结矿的综合利用率 ,降低成本 1 0 32 %。从而证明了免疫遗传算法是一种切实有效的优化方法 ,该算法为钢铁烧结矿配料问题的优化求解提供了新的思路和方法。     

凹凸棒粘土用作高水速凝注浆悬浮剂

以凹凸棒粘土作为高水速凝固化充填材料的悬浮稳定剂，考察了不同制浆机械对凹凸棒粘土制浆率的影响。采用高剪切混合乳化机预制的1％凹凸棒粘土浆配制高水速凝固化充填材料甲、已料单浆可获得满意的悬浮稳定效果。其充填体结石抗压强度早期发展迅速，后期持续增长。采用此工艺，注浆料的材料成本仅增加2％。     

Guerbet十四醇的合成与表征

以正庚醇为原料 ,通过Guerbet反应合成Guerbet十四醇 (2 戊基壬醇 ,C14 GA)。用IR、NMR和元素分析测定了C14 GA的结构 ,并研究了反应温度和用料比对其产率的影响。实验结果如下 :(1)在较优化的反应条件下 (正庚醇的总加入量为 1mol,在实验过程中 ,先加入 1/ 3mol庚醇和 1/ 4mol的KOH ,在 16 0℃下反应 2h ,然后再加入剩下的 2 / 3mol庚醇和 4g 5 %Pd -C催化剂 ,在 15 5℃下反应 6h)合成产物 ,其产率可达到 5 4 2 0 % ;(2 )所合成的产物与试图要得到的Guerbet十四醇 (2 戊基壬醇 ,C14 GA)含有相同的基团 (2×—CH3、10×—CH2 —、1×CH、1×—CH2 —O—和 1×—OH) ,而且 ,所合成的产物中 ,w (C) =79 0 6 % ,w (H ) =13 6 2 % ,与从Guerbet十四醇分子式计算的理论值w(C) =78 5 0 % ,w (H) =14 0 1%基本一致。可见所合成的产物正是Guerbet十四醇 (C14 GA)     

基于模糊层次分析法综合评判工会竞赛成绩

为综合评判工会组织的各项竞赛活动的成绩,提出了基于模糊层次分析法的综合评判措施,主要包括竞赛项目权重的确定、竞赛成绩的量化和综合评判等过程.实际应用表明,模糊层次分析法可以最大限度减少主观因素对评价结果的影响,合理地确定各项赛事在工会竞赛活动中的权重,结合竞赛成绩的量化矩阵,使得综合评价结果科学、可信.     

Performance evaluation of anti-radiation based on the gamma degradation process

In the environment of space radiation, the high-energy charged particles or high-energy photons acting on a spacecraft can cause either temporary device degradation or permanent failure. The traditional probability model is difficult to obtain reliable estimation of unit radiation resistance performance with small samples. Considering that different products will change differently after high-energy particle radiation, we construct a model based on the gamma degradation process. This model can efficiently describe the law of unit radiation resistance variation with the total radiation dose levels under the effect of the total dose and displacement damage. Finally, the proposed model is used to assess the anti-radiation performance of the N-channel power MOSFET device STRH60N20FSY3 produced by STM to obtain average unit radiation resistance, survival probability, survival function, etc.