Single Small Molecule-Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo

Photodynamic therapy (PDT) has emerged as an attractive alternative in cancer therapy, but its therapeutic effects are limited by the nonselective subcellular localization and poor intratumoral retention of small-molecule photosensitizes. Here a fiber-forming nanophotosensitizer (PQC NF) that is composed of mitochondria targeting small molecules of amphiphilicity is reported. Harnessing the specific mitochondria targeting, the light-activated PQC NFs produce approximately 110-fold higher amount of reactive oxygen species in cells than free photosensitizers and can dramatically induce mitochondrial disruption to trigger intense apoptosis, showing 20–50 times better in vitro anticancer potency than traditional photosensitizers. As fiber-shaped nanomaterials, PQC NFs also demonstrated a long-term retention in tumor sites, solving the challenge of rapid clearance of small-molecule photosensitizers from tumors. With these advantages, PQC NFs achieve a 100% complete cure rate in both subcutaneous and orthotopic oral cancer models with the administration of only a single dose. This type of single small molecule-assembled mitochondria targeting nanofibers offers an advantageous strategy to improve the in vivo therapeutic effects of conventional PDT.     

Stretchable ITO-Free Organic Solar Cells with Intrinsic Anti-Reflection Substrate for High-Efficiency Outdoor and Indoor Energy Harvesting

Flexible photovoltaic devices are promising candidates for triggering the Internet of Things (IoT). However, the power conversion efficiencies (PCEs) of flexible organic photovoltaic (OPV) devices with high conductivity poly(3,4-ethylene dioxythiophene):polystyrene sulfonate (PEDOT:PSS) electrodes on plastic are lagging behind the rigid devices due to the low transmittance of polyethylene terephthalate (PET)/PEDOT:PSS. Moreover, the poor stretchability of the commonly used plastic substrates largely hinders the practical application of wearable devices. Herein, a novel stretchable indium tin oxide (ITO)-free OPV device with a surface-texturing polydimethylsiloxane (PDMS) substrate for outdoor strong- and indoor dim-light energy harvesting is reported. The high diffuse transmittance and haze effect of the substrate enable stretchable ITO-free devices, yielding a high PCE of 15.3% under 1 sun illumination. More excitingly, the stretchable device based on textured PDMS/PEDOT:PSS maintains a comparable PCE of 20.5% (20.8% for the rigid device) under indoor light illumination. Notably, the stretchable device is much more insensitive to the light direction, maintaining 38.5% of the initial PCE at an extremely small incident angle of 10° (16.3% for glass/ITO-based counterpart). The texturing stretchable substrate provides a new direction for achieving high performance and enhanced light utilization for the stretchable light-harvesting device, suitable for indoor and outdoor applications.     

Public interest in continued use of Chinese government portals: A mixed methods study

Public adoption of policies detailed on government websites is an important topic in the field of e-government research, and researchers have mainly focused on the key factors that influence initial adoption. However, there has been much less discussion on factors influencing the continued use of government websites. This study identifies and tests a theoretical model that predicts consumers’ intentions to continue using government portals, using a mixed methods approach based on Grounded Theory. To construct a theoretical framework of public interest in continued use of government information portals, we interviewed 56 respondents and coded the interview data. Next, we tested the resulting model using data collected from a questionnaire-based survey of 354 users. The Structural Equation Modeling (SEM) results indicate that continued use is influenced by psychological perception, user characteristics, service parameters of the government portals and the government’s idea. Of these, psychological perception was found to have the strongest effect. These findings enrich the theoretical system of e-government public adoption of intention and have important practical significance for the development of Chinese government portals.     

Tungsten‐Based Materials for Lithium‐Ion Batteries

Lithium‐ion batteries are widely used as reliable electrochemical energy storage devices due to their high energy density and excellent cycling performance. The search for anode materials with excellent electrochemical performances remains critical to the further development of lithium‐ion batteries. Tungsten‐based materials are receiving considerable attention as promising anode materials for lithium‐ion batteries owing to their high intrinsic density and rich framework diversity. This review describes the advances of exploratory research on tungsten‐based materials (tungsten oxide, tungsten sulfide, tungsten diselenide, and their composites) in lithium‐ion batteries, including synthesis methods, microstructures, and electrochemical performance. Some personal prospects for the further development of this field are also proposed.     

Binary Controls on Interfacial Magnetism in Manganite Heterostructures

The complex interfacial correlations provide new routes toward tunable functionalities. Here, the wide range of tunabilities for magnetic properties are presented, including Curie temperature (from 245 to 320 K), coercive field (from 2 to 205 Oe), and saturated magnetic moment (from 0.9 to 2.8 µ_B Mn^?1), in a 9‐unit‐cell La_2/3Sr_1/3MnO₃ (LSMO) layer via modifying interfacial boundary conditions. Moreover, the LSMO/PbTiO₃‐based multilayers and superlattices that consist of PbTiO₃/LSMO/NdGaO₃ and PbTiO₃/LSMO/PbTiO₃ interfaces are characterized by two distinct Curie temperatures and coercive fields. The results reveal the feasibility of the interface‐resolved strategy based on boundary modification in fabricating potential devices with multiple accessible states for information storage. The wide‐range modulations on magnetic properties at LSMO/titanate interfaces are explained in terms of binary controls arising from the oxygen octahedral coupling (OOC) and magnetoelectric coupling (MEC). The results not only shed some light on understanding interfacial correlations in oxide heterostructures, but also pave an alternative path for exploring multiple accessible states in all‐oxide‐based electronic devices.     

稀土元素Ce填充p型方钴矿化合物的热电性能

用高温熔融-退火扩散法合成了富Co组成的方钴矿化合物CeyFexCo4-xSb12(y=0～0.42),并对化合物的结构和热电性能进行了研究.结果表明:化合物的晶格常数随Ce填充量的增加而线性增加.霍尔系数RH为正值,CeyFexCo4-xSb12化合物表现p型传导.载流子浓度和电导率随Ce填充量的增加而减少.Seebeck系数随Ce填充量的增加及温度的上升而增加.晶格热导率在Ce填充量约为0.29时达到最小值,说明在Sb组成的二十面体空洞中部分填充时,Ce的扰动对声子的散射作用最强.在725K时,组成为Ce0.29Fe1.41Co2.59Sb12.32化合物的最大无量纲热电性能指数达到0.65.     

p-GaN/Al0.35Ga0.65N/GaN应变量子阱肖特基紫外探测器

报道了p-GaN/Al0.35Ga0.65N/GaN应变量子阱结构的肖特基紫外探测器的制备及性能.器件的测试结果表明,在p-GaN/Al0.35Ga0.65N/GaN双异质结中强烈的压电极化和Stark效应共同作用下使得器件在正偏和反偏时的响应光谱都向短波方向移动了10nm.零偏下器件在280nm时的峰值响应为0.022A/W,在反向偏压为1V时,峰值响应增加到0.19A/W,接近理论值.在正向偏压下器件则呈平带状态,并在283和355nm处分别出现了两个小峰.在考虑极化的情况下,通过器件中载流子浓度分布的变化解释了器件在不同偏压下的响应特性,发现p-GaN/Al0.35Ga0.65N/GaN中的极化效应对器件的响应特性影响很大,通过改变偏压和适当的优化设计可以使探测器在紫外波段进行选择性吸收.     

一种用于电视调谐器的宽带CMOS低噪声放大器设计

介绍了一种宽带CMOS低噪声放大器设计方法,采用噪声抵消技术消除输入MOS管的噪声贡献.芯片采用TSMC 0.25μm 1P5M RF CMOS工艺实现.测试结果表明:在50～860MHz工作频率内,电压增益约为13.4dB;噪声系数在2.4～3.5dB之间;增益1dB压缩点为-6.7dBm;输入参考三阶交调点为3.3dBm.在2.5V直流电压下测得的功耗约为30mW.     

TD-SCDMA基站能力分析

在给定话务模型以及合理假设的情况下，给出不同业务占用信道资源的情况，以及TD-SCDMA基站单载波情况下所能提供的话务量及数据吞吐量。     

基于时频分布的信号相位跳变检测与估计方法

本文提出了利用时频分布的信号相位跳变检测方法,对由相位跳变而引起的时频分布峰值的变化规律进行了讨论。分析表明信号时频表示的幅度能够直观地反映出其相位的变化,因此通过对时频分布峰值特征的检测可以准确定位频率跳变时刻,并能够定量的了解这些参数的变化,从而为信号的相位调制类型识别提供帮助。相应的仿真实验证明了这一分析结论。