Nonopioid analgesics shorten the duration of postoperative ileus

Morphine inhibits propagating and stimulates nonpropagating colon contractions in monkeys and humans. The use of morphine or other opioids that inhibit propulsive contractions prolongs postoperative ileus. In contrast, ketorolac tromethamine, a nonsteroidal analgesic, has no effect on colon contractions in monkeys. In 14 patients having elective abdominal operations, bipolar electrodes were implanted on the right (n = 13) and left (n = 10) colon. Group A (n = 8) received ketorolac, 30 mg IM q6h, for pain relief. Group B (n = 6) needed supplemental morphine, 2-10 mg IV or IM, plus ketorolac to control their pain. Myoelectric activity was recorded from each subject on postop Days 1-5 and analyzed by computer for electrical control activity (ECA), short and long electrical response activity (ERA), and propagation of long ERA. There was a difference between the two groups in return of propagated long ERA bursts that correlated with clinical recovery from postoperative ileus. Postoperative analgesia with ketorolac resulted in faster resolution of ileus compared to morphine plus ketorolac because opioid-induced motor abnormalities in the colon were avoided.     

Quantitative study of the surface composition of binary alloys by Auger spectroscopy

An internal calibration method for Auger spectra of binary alloys is proposed. It comprises the in situ breaking of pre-notched, homogenized, alloys rods in ultrahigh vacuum and the immediate analysis of the fracture surface.An investigation of a wide range of compositions of each of the alloys PtSn, AgAu, AuSn and AgSn shows that the observed signal intensity ratio is proportional to the corresponding atomic ratio of the elements present, which would suggest that matrix effects do not play an important role.     

Provision of apparatus to resuscitation and intensive therapy departments of the cardiology service

The article describes monitoring systems for following critically-ill patients, and cardio-resuscitation complex, apparatus for defibrillation, and short-term anaesthesy, cardiostimulators. All these units have been elaborated and serially produced by the Radioelectronic Medical Equipment Association. Their importance and place in providing the patients treatment and diagnosis in resuscitation and intensive care departments of the cardiological service are shown.     

Histochemical study of sodium nucleinate-activated peritoneal macrophages

The activity of various enzyme groups and the levels of protein and glycogen in the peritoneal macrophages of CBA mice treated intraperitoneally with sodium nucleinate were determined histochemically with the use of cytophotometry. A significant increase in the activity of the lysosomal enzymes, such as acid phosphatase and nonspecific esterases and an increase in the activity of lactate, malate, glutamate, alpha-glycerophosphate, and beta-hydroxybutyrate dehydrogenases. NAD.H- and NADF.H-diaphorases accompanied by an increase in the level of the total protein and glycogen were observed. Analysis of the changes was indicative of an increase in the inherent physiological metabolic and functional level under the effect of sodium nucleinate. It is suggested that the macrophage sub-populations with an increased metabolic activity appeared in the peritoneal exudate of the stimulated animals. Participation of the host low molecular DNA in the maintenance of the physiological level of th nonspecific antiinfectious resistance is suggested.     

Detection and several characteristics of leach genome palindromes

About 5% of the loach (Misgurnus fossillis L.) DNA reassociates at Cot values virtually equal to zero. 50% of the reassociate are resistant to nuclease S1 treatment and reveal the properties of double-stranded structure when chromatographed on hydroxyapatite. Some proofs of palindromic (hair-pin) nature of this fraction have been obtained. An introduction of nicked scissions into the palindromic DNA by pancreatic DNAse treatment under pessimal conditions made it possible to investigated reassociation kinetics of the nucleotide sequences forming palindromes. Two different types of nucleotide sequences appeared to exist in the palindromic fraction with repetition frequencies (ni) equal to 3 X 10(2) and about 1. Homologies were revealed between these sequences and the fraction of corresponding repetition frequency of the main part of the genome. Adjacent sequences contain repetitive regions with ni equal to 10(5) and 5 X 10(3). On the basis of the data obtained some conclusions were made about the distribution of usual and inverted repetitions in the loach genome.     

Fine structure of the olfactory organ of elasmobranchs (Elasmobranchii)]

The study acetylene amines were capable of inhibiting the processes of lipids peroxidation both in the enzymatic and non-enzymatic peroxidation system. The inhibitory effect of the study compounds depended upon the degree of the compound unsaturation. An elevation of the unsaturation degree to a definite extent is attended also by an increased inhibitory action on the processes of the lipids peroxidation.