Molecular genetic diagnosis of autosomal dominant polycystic kidney disease in a newborn with bilateral cystic kidneys detected prenatally and multiple skeletal malformations

We report a case of leiomyosarcoma of the pancreas. A spindle cell pattern at light microscopy, immunocytochemical reactivity with desmin, alpha-1-antitrypsin, vimentin and actin and ultrastructural features of smooth muscle differentiation help to establish the diagnosis.     

Microcysts of the permanent adrenal cortex in perinates and infants,

Microscopic cysts in the permanent cortices of adrenal glands were studied in a series of 274 infants, some of whom had been stillborn and none of whom were more than 12 months old. After correction for length of gestation, there were no significant relationships between the occurence and number of microcysts and various maternal, placental, and perinatal diseases. A significant direct correlation was demonstrated statistically with shorter gestational period and shorter survival time after birth. We concluded that the adrenal microcysts are either a developmental feature or the result of a greater susceptibility to stress in the fetus and newborn than in older infants.