Personalities and alimentary behaviors in obese patients

The ability of lonidamine (LND), an energolytic derivative of indazole-carboxylic acid, to modulate the cytotoxic activity of cisplatin (CDDP) and epidoxorubicin (EPI), singly or in combination, was investigated in two human breast cancer cell lines (MCF7 and T47D). A 72-hr post-incubation with a non-cytotoxic concentration of LND (75 microM) increased the activity of a 1-hr CDDP treatment as well as that of a 1 to 16-hr EPI treatment. A different pattern of interaction among the drugs and modulator was observed as a function of the sequence of drug treatment. Specifically, supra-additive or additive effects of the combination were obtained in the two cell lines according to the different treatment schemes. In particular, the maximum potentiation was observed in MCF7 cells simultaneously exposed to CDDP, EPI and LND for 1 hr and then post-incubated with LND for 72 hr, and in T47 first exposed to EPI and LND, then to CDDP and LND, and finally post-incubated with LND. Flow cytometric analysis of MCF7 cell distribution in the different cycle phases showed that combined treatment with EPI/CDDP/LND was able to stabilize cell cycle perturbations (mainly G2M accumulation) induced by individual agents. The ability of LND to potentiate CDDP and EPI cytotoxicity, and the consideration that LND causes side effects different from those caused by alkylating agents and anthracyclines, make this compound an attractive candidate for multidrug combination therapy in breast cancer.     

风力发电机安装以外的作业

在德国的一项塔式起重机安装作业中．新颖的GTK1100展现了安装风力发电机以外的新用途。     

Local melting and tool slippage during friction stir spot welding of Al-alloys

Local melting and tool slippage during friction stir spot welding of different Al-alloy base materials is examined using a combination of detailed microscopy and temperature measurement. The stir zone peak temperature during welding is limited by either the solidus of the alloy in question or by spontaneous melting of intermetallic particles contained in the as-received base material. When spontaneous melting occurs this facilitates tool slippage at the contact interface. Accurate stir zone temperature and grain size measurements are essential elements when estimating the strain rate using the Zener–Hollomon relation. In Al 2024 and Al 7075 spot welds spontaneous melting of second-phase particles produces a drastic reduction in strain rate values. In Al 5754 and Al 6061 spot welds there is a strong correlation between tool rotational speed and estimated strain values. Local melted films dissolve rapidly in the high temperature stir zone and when the spot weld cools to room temperature following welding. Evidence of local melting is observed in Al 7075 friction stir spot welded joints made using a combination of rapid quenching, high plunge rates, and extremely short dwell time settings.     

Visualization research with large displays [analysis ofcommunication networks and services]

We describe our research at AT&T Infolab on using large displays to interactively analyze and visualize AT&T's communication networks and services     

Structural features determining the antibiotic potencies of natural and synthetic hop bitter resins, their precursors and derivatives

Twenty-six hop bitter resins, some hitherto not investigated, were tested for antimicrobial activities. Gram-positive bacteria were much more sensitive than Gram-negative ones. The inhibitory effect against Bacillus subtilis 168 was measured by several methods and the general rule could be established that the antibiotic properties are mainly dependent on the hydrophobic parts of the molecules. Thus the acyl-lupuphenones (2-acyl-3,5-4,4',6-tri(3-methyl-2-butenyl)-cyclohexane-triones (1, 3, 5) having three prenyl and one acyl side chain are the most active substances. Their minimum inhibitory concentration (MIC) increases from the capro (0.5 muM) to the aceto derivative (11 muM). Any substitution with hydrophilic functions or loss of hydrophobic groups causes reductions in biological activity. This is most evident with the corresponding acyl-phloroglucine precursors (2-acyl-1,3,5-trihydroxybenzenes) which lack the three prenyl side chains (MIC, 110 to 5050 muM respectively). Conversion of the central six-membered ring structure into a five-membered one results in additional losses of antimicrobial activity. These findings support the proposal that the lipophilic region of the cell membrane represents the target site for the hop bitter resins.     

覆膜陶瓷粉末烧结过程热应力场研究

研究覆膜陶瓷粉末在选择性激光烧结过程中的热应力场 ,分析烧结过程中各种工艺参数同烧结件质量之间的关系。通过编制相应的程序对其热应力场进行数值模拟 ,从而优化工艺参数 ,确保烧结件质量。     

新型智能变送器的研制

介绍了一种新型变送器,该装置可接收多种输入信号,具有模拟、数字及语音３种输出功能。分析了其原理、内部结构及输出特点。该装置通用性强、可靠性高,可用在工业测控系统进行各种参数的检测与变送。