终止浪涌的简单高效浪涌电流限制器

通常为200W或200W以上负载供电的离线电源,都需要采用浪涌电流限制器.毫无限制的浪涌电流可达数百安培.这样大的电流会损坏线路整流器,融断保险、使输入滤波电感器开路、或损坏PFC(功率因数校正)滤波器电容.     

Ultrasound elastography: a dynamic programming approach

This paper introduces a 2-D strain imaging technique based on minimizing a cost function using dynamic programming (DP). The cost function incorporates similarity of echo amplitudes and displacement continuity. Since tissue deformations are smooth, the incorporation of the smoothness into the cost function results in reduced decorrelation noise. As a result, the method generates high-quality strain images of freehand palpation elastography with up to 10% compression, showing that the method is more robust to signal decorrelation (caused by scatterer motion in high axial compression and nonaxial motions of the probe) in comparison to the standard correlation techniques. The method operates in less than 1 s and is thus also potentially suitable for real time elastography.      

Disruptive Technologies,Services, or Business Models?

Convergence in the realm of media, consumer electronics, computer technologies, and telecommunications has contributed to societal changes in terms of individual expectations and behavior leading to the re-appraisal of traditional market segments. Key innovations like the internet create a global platform that provides for new means in product and services configuration. This expands opportunities and threats in the business environment contributing to increased competition in a dynamic environment where traditional boundaries are shifting. In a world of converging technologies, increasing marketplace dynamics and rapid technological advances, new upcoming “disruptive technologies” such as Voice-over-IP (VoIP) pose threats to traditional telecommunications companies. Business leaders in order to succeed need to be “thinking outside the box”. We introduce the concept of a business model as a tool in crafting strategy for the purpose of achieving sustainable innovation in the face of the reshaping of the industry and the market. We apply this model to the VoIP market and in particular the Skype technology and service. The significance of this contribution is that it highlights the importance of developing an innovative business model to take advantage of disruptive technologies. Our analysis of the dimensions of innovations shows that the more dimensions the greater the impact. ICT convergence is leading to a paradigm shift with innovation effects that are both effective and disruptive. Thus, leading to equally disruptive business models reshaping innovation strategy.

A Generalized System for Photo-Responsive Membrane Rupture in Polymersomes

Polymersomes are vesicles whose membranes are comprised of self-assembled block co-polymers. We recently showed that co-encapsulating conjugated multi-porphyrin dyes in a polymersome membrane with ferritin protein in the aqueous lumen confers photo-lability to the polymersome. In the present study, we illustrate that the photo-lability can be extended to vesicles containing dextran, an inert and inexpensive polysaccharide, as the luminal solute. Here we explore how structural features of the polymersome/porphyrin/dextran composite affect its photo-response. Increasing dextran molecular weight, decreasing block copolymer molecular weight, and altering fluorophore-membrane interactions results in increasing the photo-responsiveness of the polymersomes. Amphiphilic interactions of the luminal encapsulant with the membrane coupled with localized heat production in the hydrophobic bilayer likely cause differential thermal expansion in the membrane and the subsequent membrane rupture. This study suggests a general approach to impart photo-responsiveness to any biomimetic vesicle system without chemical modification, as well as a simple, bio-inert method for constructing photo-sensitive carriers for controlled release of encapsulants.     

Self‐Healing Fibre Reinforced Composites via a Bioinspired Vasculature

This paper demonstrates the first steps towards self‐healing composites that exploit a design philosophy inspired by the damage tolerance and self‐repair functions of bone. Cracking in either fibre reinforced polymers (FRP) or bone, if left unattended, can grow under subsequent cyclic stresses eventually leading to catastrophic failure of the structure. On detection of cracks, an FRP component must be repaired or completely replaced, whereas bone utilises a series of complex processes to repair such damage. Under normal circumstances, these processes allow the skeleton to continually perform over the lifespan of the organism, a highly desirable aspiration for engineering materials. A simple vasculature design incorporated into a FRP via a “lost wax” process was found to facilitate a self‐healing function which resulted in an outstanding recovery (≥96%) in post‐impact compression strength. The process involved infusion of a healing resin through the vascule channels. Resin egress from the backface damage, ultrasonic C‐scan testing, and microscopic evaluation all provide evidence that sufficient vascule–damage connectivity exists to confer a reliable and efficient self‐healing function.     

Biospecific Self‐Assembly of a Nanoparticle Coating for Targeted and Stimuli‐Responsive Drug Delivery

Biology provides a range of materials, mechanisms, and insights to meet the diverse requirements of nanomedicine. Here, a biologically based nanoparticle coating system that offers three characteristic features is reported. First, the coating can be self‐assembled through a noncovalent biospecific interaction mechanism between a lectin protein (Concanavalin A) and the polysaccharide glycogen. This biospecific self‐assembly enables the coating to be applied simply without the generation of covalent bonds. Second, glycoprotein‐based biofunctionality can be incorporated into the coating through the same noncovalent biospecific interaction mechanism. Here, the glycoprotein transferrin is incorporated into the coating since this moiety is commonly used to target cancer cells through a receptor‐mediated endocytosis mechanism. Third, the coating can be triggered to disassemble in response to a reduction in pH that is characteristic of endosomal uptake. In a proof‐of‐concept study, comparing coated and uncoated nanoparticles, model drug‐loaded nanoparticles (doxorubicin‐loaded mesoporous silica nanoparticles) are prepared and it is observed that the coated nanoparticle has enhanced cytotoxicity for cancer cell lines but attenuated cytotoxicity for noncancerous cell lines. These studies demonstrate that biology provides unique materials and mechanism appropriate to meet the needs for emerging applications in the medical and life sciences.     

Miniaturized Flexible Electronic Systems with Wireless Power and Near‐Field Communication Capabilities

A class of thin, lightweight, flexible, near‐field communication (NFC) devices with ultraminiaturized format is introduced, and systematic investigations of the mechanics, radio frequency characteristics, and materials aspects associated with their optimized construction are presented. These systems allow advantages in mechanical strength, placement versatility, and minimized interfacial stresses compared to other NFC technologies and wearable electronics. Detailed experimental studies and theoretical modeling of the mechanical and electromagnetic properties of these systems establish understanding of the key design considerations. These concepts can apply to many other types of wireless communication systems including biosensors and electronic implants.     

Enzymatic Writing to Soft Films: Potential to Filter,Store, and Analyze Biologically Relevant Chemical Information

Sensor‐based chemical analyses commonly enlist either the molecular recognition capabilities of biology (e.g., enzyme biosensors) or advanced information processing algorithms (e.g., the electronic nose). Here, a hybrid approach is proposed in which an enzyme is used to “filter” chemical information and write this information to a film which then serves as a permanent storage medium that can be ‘read’ repeatedly, interactively, and by multiple sensor modalities. This approach is demonstrated by analyzing common dietary phenols that are reported to offer health benefits. Specifically, the enzyme tyrosinase is used to convert these phenols into reactive quinones that graft (i.e., write) to a chitosan film. Grafting can be detected by optical, mechanical, and electrochemical sensors. Importantly, grafting confers redox activity to the films and this redox activity can be probed interactively by advanced electrochemical methods that allow the intrinsic redox reactivities to be compared, redox interactions to be identified, and biologically relevant redox activities to be examined. The transfer of chemical and biological information to a film is envisioned to provide broader access to the extensive capabilities offered by sensor technologies and signal processing methodologies.     

Superswelling Microneedle Arrays for Dermal Interstitial Fluid (Prote)Omics

The noninvasive sampling of dermal interstitial fluid (ISF) for the monitoring of clinical biomarkers is a greatly appealing area of research. The identification of molecular biomarkers in biological fluids has been accelerated with -omics analyses but remains limited in ISF because of its time-consuming and complex extraction process. Here, the generation of microneedle (MN) patches made of superabsorbent acrylate-based hydrogels for the rapid sampling of dermal ISF is described to explore its proteome. In depth, iterative optimization allows the identification of novel acrylate-based compositions with the required chemical, mechanical, and biocompatibility properties allowing proteomic analysis of the extracted ISF for the first time after sampling with swelling MNs. The generated MN arrays show no cytotoxic effect, successfully cross the stratum corneum, and can collect up to 6 µL of dermal ISF in 10 min in vivo. Proteomics lead to the detection of 176 clinically relevant biomarkers in the collected samples validating the use of ISF as a relevant bodily fluid for disease monitoring and diagnostic. Importantly, it is discovered that extraction fingerprint is strongly dependent on the MNs chemistry, and thus specific biomarkers could be selectively extracted by tuning the composition of the patch, making the system versatile and specific.