Development of an outcomes management program at an academic medical center

Donor CD4+ and CD8+ T cells mediate graft-vs.-leukemia (GVL) responses in the allogeneic bone marrow transplantation (alloBMT) setting. To evaluate the role of functional T cell subsets in the mediation of GVL, alloreactive donor CD4+ (Th1/Th2) and CD8+ (Tc1/Tc2) T cells of defined cytokine phenotype were generated by in vitro culture. A leukemia/transplantation model (B6 into B6C3F1; 1050 cGy host irradiation) was established using the bcr/abl-transfected myeloid leukemia line, 32Dp210 (P210; H-2k). Leukemia control mice (1X10(4) P210 cells per recipient) died at day 12.0 post-BMT. Recipients of the CD4+, Th1-type or CD8+, Tc1-type populations were conferred a survival advantage (death at 20.7 and 23.5 days post-BMT, respectively). In contrast, the CD4+, Th2-type population did not mediate GVL (death at 12.3 days). Furthermore, cell mixing experiments demonstrated that the Th2 subset abrogated both Th1- and Tc1-mediated GVL. The CD8+, Tc2 population, which secreted type II cytokines and lysed the P210 leukemia target in vitro, mediated GVL in some experiments; interestingly, the magnitude of Tc2-mediated GVL was inversely related to the level of interleukin-10 (IL-10) secreted in vitro by the Tc2 population. These studies therefore indicate that alloreactive T cells of type I phenotype maximally generate GVL, and that type I/type II interactions are an important consideration for allogeneic transplantation in the setting of leukemic hosts.     

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

Cyclin D1 is part of a cell cycle control node consistently deregulated in most human cancers. However, studies with cyclin D1-null mice indicate that it is dispensable for normal mouse development as well as cell growth in culture. Here, we provide evidence that ras-mediated tumorigenesis depends on signaling pathways that act preferentially through cyclin D1. Cyclin D1 expression and the activity of its associated kinase are up-regulated in keratinocytes in response to oncogenic ras. Furthermore, cyclin D1 deficiency results in up to an 80% decrease in the development of squamous tumors generated through either grafting of retroviral ras-transduced keratinocytes, phorbol ester treatment of ras transgenic mice, or two-stage carcinogenesis.     

Hyperbaric oxygenation and current methods of detoxication in multimodal intensive therapy of diffuse peritonitis

The course of diffuse peritonitis has been followed up in 219 patients, 20 of these with the reactive, 165 with toxic, and 34 with the terminal stages of the condition. Multiple-modality intensive care included, besides routine therapy, local abdominal hypothermia, UV irradiation of autoblood (UVIAB), and, if indicated, hyperbaric oxygenation (HBO) and hemoperfusion. In addition to clinical tests, immunobiochemical monitoring of medium-molecular peptide fractions MM1 and MM2 and index of their distribution, as well as of circulating immune complexes CIC1 and CIC2 and the levels of immunoglobulins IgA, IgM, and IgG were the criteria for assessing the severity of intoxication and efficacy of intensive care and for predicting the course and outcome of the disease. The results indicate that HBO in combination with hemoperfusion, local abdominal hypothermia, and UVIAB have a positive impact on the clinical picture of the disease and on the time course of markers of endogenous intoxication and humoral immunity in patients with the terminal and toxic phases of diffuse peritonitis.     

发电机推力轴承温度量异常的处理方法

分析湖北黄龙滩水力发电厂3、4号水轮发电机自投运以来推力轴承瓦温度计引线频繁断线及温度量不能正常显示上传的原因,介绍相关改进优化处理方法。     

1957-2017年泾河流域降雨量及降雨侵蚀力时空变化分析

泾河流域受土壤侵蚀的影响,水土流失较为严重,为对流域水土流失风险评估和防治等提供参考依据,根据1957-2017年泾河流域5个气象站点的日降水资料,运用ArcGIS空间插值、小波分析、R/S分析等方法,分析了该时段降雨量及降雨侵蚀力时空变化规律。结果表明:泾河流域及各气象站点的降雨量与降雨侵蚀力均呈显著正相关关系;泾河流域降雨量与降雨侵蚀力年内分布不均,主要集中在夏季,分别占全年的67.80%和52.86%;泾河流域年均降雨量和降雨侵蚀力分别为496.83 mm和1 481.24 (MJ·mm)/(hm~2·h),年际总体呈波动上升趋势且未来降雨侵蚀力将延续增加趋势,两者均在1996和2009年出现突变点且第一主周期分别为27和17 a;泾河流域降雨量和降雨侵蚀力在空间上均呈从西北到东南递增的趋势。     

Co-located collaborative visual analytics around a tabletop display

Co-located collaboration can be extremely valuable during complex visual analytics tasks. We present an exploratory study of a system designed to support collaborative visual analysis tasks on a digital tabletop display. Fifteen participant pairs employed Cambiera, a visual analytics system, to solve a problem involving 240 digital documents. Our analysis, supported by observations, system logs, questionnaires, and interview data, explores how pairs approached the problem around the table. We contribute a unique, rich understanding of how users worked together around the table and identify eight types of collaboration styles that can be used to identify how closely people work together while problem solving. We show how the closeness of teams’ collaboration and communication influenced how they performed on the task overall. We further discuss the role of the tabletop for visual analytics tasks and derive design implications for future co-located collaborative tabletop problem solving systems.     

Beyond interpretation: Reply to Cummins' response

In his response to my Why There Are No Mental Representations, Robert Cummins accused me of having misinterpreted his views, and attempted to undermine a crucial premise of my argument, which claimed that one could only define a semantic type non-semantically by stipulating which tokens should receive a uniform interpretation. I respond to the charge and defend the premise.     

数千上万核上模拟结果的并行可视化

在科学与工程计算中,在数千上万核上,模拟包含上亿网格单元的模型通常输出TB量级的时变数据集。这些数据集包含多个时刻的数据,每个时刻的数据分布存储在数千个文件,单时刻的数据量达到几GB甚至几十GB。为了并行地可视化这种时变数据集,本文设计了基于网格片的层次化数据结构,基于该数据结构改进和优化了并行可视化流程和数据通信算法。在集成到可视化软件后,实现了两个应用的模拟结果可视化。实测数据表明,对于单时刻5GB和32GB的数据,在数十上百个处理器核上,从数据读入到获得体绘制结果的时间分别为19秒和80秒,交互操作为2秒到10秒;三维面绘制在数秒钟内,切片分析在2秒以内。     

The micromechanics of fatigue-induced delamination of a graphite/epoxy composite

Fatigue crack growth in the resin layer between 0 and 90 plies of an AS/3501-5A graphite fibre/epoxy composite is discontinuous. Regularly spaced extensions of the crack front occur after periods of arrest. Crack compliance and tip strain fields have been measured to determine how the local minimum (K _min ^l) and maximum (K _max ^l) crack tip stress intensities affect growth. Contact of the fracture surfaces and swelling of the 90° ply modify these local stress intensities by an amount sensitive to load ratio (R), and the resulting propagation rate depends strongly onR. A model capable of describing thisR effect relates the distance of each individual crack advance to K_max ^l and the duration of each arrest toK _mnax ^l -K _min ^l, i.e., to K _eff. We discuss the genesis of this model, and its explanation of the large Paris law coefficient which results if growth rates are instead expressed against the applied cyclic stress intensity.