Cytochrome P450 3A4 activity in premenopausal and postmenopausal women, based on 6-beta-hydroxycortisol:cortisol ratios

STUDY OBJECTIVE: To characterize cytochrome P450 (CYP) 3A4 activity in premenopausal and postmenopausal women by evaluating the urinary 6-beta-hydroxycortisol:cortisol ratio. DESIGN: Prospective study SUBJECTS: Thirteen premenopausal and 13 postmenopausal women who were healthy and not receiving drugs known to affect CYP3A4 activity INTERVENTIONS: Beginning on day 2 of menses, premenopausal women collected first morning urine samples every other day for a complete menstrual cycle. Postmenopausal women collected first morning urine every other day for 28 days. MEASUREMENTS AND MAIN RESULTS: Mean weekly 6-beta-hydroxycortisol:cortisol ratios did not differ during the phase (week) of the menstrual cycle. Daily ratios did not differ in postmenopausal women. No difference between premenopausal and postmenopausal women was found on comparing overall median ratios. CONCLUSION: Cytochrome P450 3A4 activity as measured by 6-beta-hydroxy cortisol:cortisol ratio did not differ by week of menstrual cycle, suggesting no menstrual cycle-related changes. Menopause does not appear to be associated with differences in CYP3A4 activity, compared with premenopause.     

输电线路自适应无通道保护(一)故障分析与保护原理

在故障分析的基础上，提出了利用单端故障信息的输电线路全线速动保护原理和动作判据。保护原理由互为补充的两种动作模式－－延时动作模式和瞬时动作模式构成。延时模式利用线路对端开关动作信息加速本端保护动作；瞬时模式根据阻抗继电器Ⅱ段动作定值瞬时动作跳闸，再利用重合闸并根据开关动作后的信息纠正错误动作的结果。保护动作判据由4个独立的故障序分量的比值构成，仿真实验证实了所提保护原理和动作判据的正确性。     

Qualified,But Not Choosing STEM at University: Unconscious Influences on Choice of Study

Abstract

This article offers explanations as to why good candidates for mathematics or physics degrees might opt to study subjects other than STEM (science, technology, engineering, mathematics) subjects at university. Results come from analysis, informed by psychoanalytic theory and practice, of narrative-style interviews conducted with first-year undergraduates and from survey data. It is argued that psychoanalytic interpretations have a role in educational research. Also, it is shown that unconscious forces influenced young peoples’ decision making. Implications for policy are discussed, in particular, the issues of (a) the role of commitment and (b) being good enough to study a STEM discipline.     

Seeking the user interface

User interface design and coding can be complex and messy. We describe a system that uses code search to simplify and automate the exploration of such code. We start with a simple sketch of the desired interface along with a set of keywords describing the application context. If necessary, we convert the sketch into a scalable vector graphics diagram. We then use existing code search engines to find results based on the keywords. We look for potential Java-based graphical user interface solutions within those results and apply a series of code transformations to the solutions to generate derivative solutions, aiming to get solutions that constitute only the user interface and that will compile and run. We run the resultant solutions and compare the generated interfaces to the user’s sketches. Finally, we let programmers interact with the matched solutions and return the running code for the solutions they choose. The system is useful for exploring alternative interfaces to the initial and for looking at graphical user interfaces in a code repository.     

The revised fundamental theorem of moment invariants

A revised fundamental theorem of moment invariants for pattern recognition which corrects the fundamental theorem proposed by M.K. Hu (1962), is presented. The correction affects neither similitude (scale) nor rotation invariants derived using the original theorem, but it does affect features invariant to general linear transformations. Four of the latter invariants were presented originally by Hu. These are revised to take the correction to the fundamental theorem into account. Furthermore, these four invariants are combined to yield three new invariants, which are additionally invariant to changes in the illumination of an image     

Perception of solar UVB radiation by phytophagous insects: behavioral responses and ecosystem implications

Most of our present knowledge about the impacts of solar UVB radiation on terrestrial ecosystems comes from studies with plants. Recently, the effects of UVB on the growth and survival of consumer species have begun to receive attention, but very little is known about UVB impacts on animal behavior. Here we report that manipulations of the flux of solar UVB received by field-grown soybean crops had large and consistent effects on the density of the thrips (Caliothrips phaseoli, Thysanoptera: Thripidae) populations that invaded the canopies, as well as on the amount of leaf damage caused by the insects. Solar UVB strongly reduced thrips herbivory. Thrips not only preferred leaves from plants that were not exposed to solar UVB over leaves from UVB-exposed plants in laboratory and field choice experiments, but they also appeared to directly sense and avoid exposure to solar UVB. Additional choice experiments showed that soybean leaf consumption by the late-season soybean worm Anticarsia gemmatalis (Lepidoptera: Noctuidae) was much less intense in leaves with even slight symptoms of an early thrips attack than in undamaged leaves. These experiments suggest that phytophagous insects can present direct and indirect behavioral responses to solar UVB. The indirect responses are mediated by changes in the plant host that are induced by UVB and, possibly, by other insects whose behavior is affected by UVB.