Evaluation of the paraskeletal clamp system (Mennen plate) in treatment of mandibular fractures

In this study, we used the relatively recent Paraskeletal clamp system (Mennen plate) to evaluate its effectiveness in the treatment of mandibular fractures. This study was conducted on eight patients with mandibular fractures selected from the out patient clinic, Oral Surgery Department, Faculty of Oral and Dental Medicine, Cairo University. Patient sample consisted of six males and two females, four patients were children below the age of 11 years, while the other four were edentulous above the age of 58. Each patient was thoroughly examined both clinically and radiographically. Data collected from each patient were recorded in a special examination chart. Under general anesthesia, the fracture was exposed using a submandibular approach. The fractured segments were reduced and fixed using micro-5 Mennen plates. All patients were followed up both clinically and radiographically for six months postoperatively. Results obtained from this study showed uneventful healing of all patients with no cases of non-union, bony infection or osteomyelitis as proven both clinically and radiographically. All the patients presented normal functioning occlusion and facial symmetry. No bony step deformities were detected.     

No effects of DC and 60-Hz AC magnetic fields on the first mitosis of two species of sea urchin embryos

The early divisions of sea urchin eggs was used as a model to study the effects of static and of 60 Hz sinusoidal magnetic fields. Two species were used (Sphaerechinus granularis and Paracentrotus lividus). Eggs were fertilized and exposed in two separate coils to the fields (up to 8 mT). Great care was taken to control the temperature of each sample. No difference was found in the time of the first division that could not be attributed to a temperature difference between samples. Comparison is made with other published data on various species.     

Dietary deficiency of cystine and methionine in rats alters thiol homeostasis required for cyanide detoxification

Nutritional status is an important factor in modulating the metabolic fate of xenobiotics. Sulfur amino acid (SAA) deficiency has been proposed as a risk factor for human neurological diseases among protein-poor populations subsisting on the cyanophoric plant cassava. Female Sprague-Dawley rats were used to develop and define a model of SAA deficiency for use in future studies examining cassava-related neurotoxicity. Rats were kept in metabolic cages for 7-21 d and fed a balanced diet (BD) of known composition or a comparable diet selectively deficient in methionine and cystine (SAA-free diet). Animals fed the SAA-free diet failed to thrive, lost body weight, excreted porphyrinic materials, and showed a steep and persistent reduction of urinary inorganic sulfate. In contrast, animals on the BD gained body weight and maintained baseline output of urinary inorganic sulfate. Urinary thiocyanate excretion did not differ between groups, but plasma thiocyanate concentrations reached double that in SAA-deficient rats. Increased plasma thiocyanate suggests mobilization of sulfur amino acids from endogenous sources. Liver glutathione and blood cyanide concentrations were similar in animals on the BD and the SAA-deficient diet. In summary, a diet free of methionine and cystine results in increased retention of inorganic sulfur as thiocyanate and a near absence of inorganic sulfur excretion in urine.     

The morphogenic characteristics of human transitional-cell bladder tumors in Ukraine after the accident at the Chernobyl Atomic Electric Power Station]

Ten 13-17-year-old boys with pathocharacterologic peculiarities in premorbid period were examined. Syndrome of affective excitability was observed in pure form in 5 juveniles, while it was combined with hysteric features in 3 patients and with affective instability in 2 ones. These peculiarities of personality resulted in behavioral deviations which promoted the development of alcoholism and exaggerated of disorders conditioned by this disease. Course of alcoholism in the studied cases was unfavourable (binges, intake of large doses of alcohol and of the substitutes, etc) with pronounced disorders of behaviour up to aggression and delinquency. It was established that psychologic motivation (search of psychologic comfort, satisfaction of the need of actualization of personality, etc) played an important role both in development of the disease and in forming its clinical peculiarities.     

Cytotoxic activity of platelets and peripheral blood mononuclear cells from oncology patients and healthy donors

Testicular germ cell tumour is said to be a model for curable neoplasm. However, the prognosis of primary extragonadal germ cell tumour does not appear to be as promising. Though similar in histology, the biology of primary extragonadal germ cell tumour is different as exemplified by the patients in this review. Eight patients with primary mediastinal germ cell tumours were treated with intensive cisplatin-based chemotherapy. All, except one, had non-seminomatous components. The poor prognosis of mediastinal germ cell tumour is due to a combination of poor treatment results with the cisplatin-based regimen and the development of non-germ cell and haematological malignancies.     

Normal growth hormone secretion in growth hormone insufficient children retested after completion of linear growth

Tuberculosis of the cervical spine is rare, comprising 3-5% of cases of tuberculosis of the spine. Eight patients with tuberculosis of the cervical spine seen during 1989-1992 were reviewed. They all presented with neck pain. The 4 children presented with a kyphotic deformity. In all the children the disease was extensive, with a large prevertebral abscess formation, while in the adults it was localised to one or two motion segments. Cord compression was present in 4 of the 8 patients. All the patients were treated with antituberculosis drugs and 6 underwent surgery. There was full neurological recovery in all patients. The kyphosis was improved though not fully corrected. There was a problem in stabilisation of severe involvement of the body and dens of C2. Surgery seems to play a major role in the treatment of tuberculosis of the cervical spine.     

Mutagenesis of cardiac troponin I. Role of the unique NH2-terminal peptide in myofilament activation

Phosphorylation of Ser residues in the NH2-terminal extension unique to cardiac troponin I (cTnI) is known to occur through protein kinase A and to alter myofilament Ca2+ activation (Robertson, S. P., Johnson, J. D., Holroyde, M. J., Kranias, E. G., Potter, J. D., and Solaro, R. J. (1982) J. Biol. Chem. 257, 260-263). Yet, how the NH2-terminal extension may itself affect thin filament Ca2+ signaling is unknown. To approach this question we have used molecular cloning, mutagenesis, and bacterial synthesis of a full-length cTnI and a truncated mutant (cTnI/NH2) missing the 32 amino acids. Using reconstituted preparations we could show no differences between cTnI and cTnI/NH2 either in inhibition of actomyosin ATPase activity, in Ca(2+)-reversible inhibitory activity, or in the relation between pCa and Ca2+ binding to the regulatory site of cTnC at either pH 7.0 or 6.5. There were also no significant differences at either pH in the pCa-MgATPase activity relation of myofibrils into which the various species of TnI has been exchanged. Our results indicate: 1) that phosphorylation most likely induces a new state of TnI activity rather than altering an intrinsic effect of the NH2-terminal peptide on Ca2+ activation; and 2) that domains outside the NH2-terminal extension are important with regard to differences in effects of acidic pH on Ca2+ activation on cardiac and skeletal myofilaments.     

DRGs and MDCs in the evaluation of surgical departments: the experience of Local Health Screening Unit No. 13 of the Veneto Region

This paper discusses the utilization of MDC and DRG for the evaluation of the activities of surgical divisions. Discharge data on 1901 admissions of the second semester 1992 (97.1% of admissions) to three surgical divisions of ULSS 13 in Veneto Region were assigned to HCFA-DRG, 6th version: 423 (22.3%) in division A; 681 (35.8%) in B; 797 (41.9%) in C. MDC 6 (Diseases and Disorders of the Digestive System) was the most frequent MDC in every division; MDC 4 (Diseases and Disorders of the Respiratory System) had an high proportion only in division A, showing the peculiar feature of this division that effects the thoracic surgery of the whole ULSS. Division A had the highest proportion (56.3%) of admissions for surgical DRGs; division C the lowest (35.4%). DRG 119 (Vein Ligation and stripping) was the most frequent surgical DRG in every division: in the whole sample its DRG specific pre-surgical average length of stay was 1.7 days, and the total average length of stay was 4.7 days. MDC and DRG were usefull in describing case-mix, but it is fundamental to have an appropriate knowledge of these instruments, to avoid in reaching inappropriate considerations, because it was inappropriate the use of the same instruments.