Filtering spam from bad neighborhoods

One of the most annoying problems on the Internet is spam. To fight spam, many approaches have been proposed over the years. Most of these approaches involve scanning the entire contents of e-mail messages in an attempt to detect suspicious keywords and patterns. Although such approaches are relatively effective, they also show some disadvantages. Therefore an interesting question is whether it would be possible to effectively detect spam without analyzing the entire contents of e-mail messages. The contribution of this paper is to present an alternative spam detection approach, which relies solely on analyzing the origin (IP address) of e-mail messages, as well as possible links within the e-mail messages to websites (URIs). Compared to analyzing suspicious keywords and patterns, detection and analysis of URIs is relatively simple. The IP addresses and URIs are compared to various kinds of blacklists; a hit increases the probability of the message being spam. Although the idea of using blacklists is well known, the novel idea proposed within this paper is to introduce the concept of ‘bad neighborhoods’. To validate our approach, a prototype has been developed and tested on our university's mail server. The outcome was compared to SpamAssassin and mail server log files. The result of that comparison was that our prototype showed remarkably good detection capabilities (comparable to SpamAssassin), but puts only a small load on the mail server. Copyright © 2010 John Wiley & Sons, Ltd.     

Transfer between pose and illumination training in face recognition.

The relationship between pose and illumination learning in face recognition was examined in a yes–no recognition paradigm. The authors assessed whether pose training can transfer to a new illumination or vice versa. Results show that an extensive level of pose training through a face–name association task was able to generalize to a new illumination (Experiments 1 and 3), but an equal level of illumination training failed to generalize to a new pose (Experiment 2). The transfer of pose training was likely to depend on a relatively extensive level of training because the same faces with reduced level of exposure (Experiment 4) were unable to reproduce the transfer effect. The findings suggest that generalization of pose training may be extended to different types of image variation, whereas generalization of illumination training may be confined within the trained type of variation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Modeling the pH dependent hydrolysis of VX for aqueous releases

The fate of chemical warfare agents (CWAs) in aqueous environments is not well characterized. Limited physical and kinetic data are available in the open literature for this class of chemicals, in part due to the dangers associated with exposure to these compounds. As a result, the development of methods for determining the persistence and extent of impact of a waterborne chemical agent release remains largely unanswered. In this study a basic hydrolysis model was developed to track the fate of VX (O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate) from an instantaneous point source aqueous release. Hydrolysis product generation tracking was developed to determine the instantaneous pH within the local dispersive environment. Using instantaneous local pH values, the impact of pH on the persistence of VX hydrolysis rate was investigated for three different aqueous environments with varying dispersive conditions. Modeling results indicate that an accurate characterization of the pH dependence of the hydrolysis rate constant becomes more important in lower pH and lower turbulence environments. With this basic model, estimates of the time and extent of lethality of a VX release can be made.     

Impaired timing precision produced by striatal D2 receptor overexpression is mediated by cognitive and motivational deficits.

Increased striatal dopamine D2 receptor activity is thought to contribute to the pathophysiology of schizophrenia. To model this condition in mice, Kellendonk et al. (2006) generated transgenic mice that selectively overexpress the D2 receptor in striatum (D2OE). Drew et al. (2007) reported that D2OE mice display deficits in interval timing and motivation. The present study further explored the impaired timing in D2OE mice. Experiment 1 assessed the role of motivation in producing timing deficits in the peak procedure and found that performance in D2OE mice was improved by increasing motivation. In addition, performance was impaired in control mice when motivation was decreased. In Experiment 2, we found that D2OE mice have no timing impairment when tested using the bisection task, a procedure in which the measure of timing performance is less influenced by motivation to respond. In Experiment 3, we also used the bisection task and found selective impairment in timing of long durations in D2OE mice. These results suggest that striatal D2 overexpression impairs timing by decreasing motivation and through its impact on working memory and/or sustained attention. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

NMR studies of caldesmon-calmodulin interactions

The binding of the calcium-regulatory protein calmodulin (CaM) to caldesmon (CaD) contributes to the regulation of smooth muscle contraction. Two regions of caldesmon have been identified as putative calmodulin-binding domains. We have earlier reported on the binding of one of these domains to calmodulin (Zhang & Vogel (1994) Biochemistry 33, 1163-1171). Here we have studied the binding of CaM to synthetic peptides of CaD which contain: (1) both the first and second CaM-binding domains; (2) the second CaM-binding domain; and (3) the sequence between the first and second CaM-binding domains. Two-dimensional transferred nuclear Overhauser enhancement proton NMR measurements as well as circular dichroism studies of a 22-residue peptide NKETAGLKVGVSSRINEWLTK, which contains the second CaM-binding domain, show that only the C-terminal half of the peptide becomes alpha-helical upon binding to CaM. Somewhat surprisingly, the shorter 9-residue peptide SRINEWLTK was sufficient to form a 1:1 complex with CaM; this peptide appears to bind as a 3(10)-helix. Proton-carbon-13 correlation NMR titration studies with specifically labeled [methyl-13C]methionine CaM were used to study the participation of the hydrophobic regions in both domains of the dumbbell shaped CaM in peptide binding. Binding of a 54-residue CaD peptide containing both CaM-binding domains affects all the 8 Met residues in the two hydrophobic domains of CaM (only Met 76 in the linker region of CaM is not involved), while binding of the second CaM-binding domain of CaD influences principally Met 51, 71, and Met 124, 144. Simultaneous binding to CaM of two peptides comprising the first and the second CaM-binding domains also caused changes to all Met residues except Met 76. Taken together, these data demonstrate that both CaM-binding domains of CaD can bind simultaneously to the two hydrophobic regions of CaM.     

Twin similarity in cardiovascular stress response.

Measured blood pressure and heart rate in 12 pairs of identical and 21 pairs of fraternal male twins (aged 54–64 yrs) during a mental arithmetic task and during submersion of the S's left hand in 4°C water for 60 sec. The results suggest that certain measures of cardiovascular reactivity to laboratory stressors may be heritable for both physical and psychological stressors. The possible role of this genetic component in the etiology and course of coronary heart disease is discussed. (14 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole

OBJECTIVE: To study the effect of adjuvant chemotherapy after curative hepatic resection in patients with hepatocellular carcinoma. DESIGN: A randomized controlled trial. SETTING: A tertiary referral center. PATIENTS: During a 54-month period, 142 patients with hepatocellular carcinoma underwent hepatic resection at 1 institution. Sixty-six patients who survived the operation and had no demonstrable evidence of residual disease on ultrasonographic examination and hepatic angiographic testing at 1 month after surgery agreed to participate in the study. The median follow-up time was 28.3 months. INTERVENTION: Thirty patients received a combination of intravenous epirubicin hydrochloride (8 doses of 40 mg/m2 each at 6-week intervals) and transarterial chemotherapy using an emulsion of iodized oil and cisplatin (3 courses with a maximum dose of 20 mL each at 2-month intervals). Thirty-six patients had no adjuvant treatment. MAIN OUTCOME MEASURES: Recurrence rate and disease-free survival. RESULTS: A total of 138 courses of intravenous epirubicin was given to the 30 patients. Sixty-one courses of transarterial chemotherapy were given to only 29 of the 30 patients assigned to the treatment group, because the hepatic artery in 1 patient was thrombosed. Six patients (20%) had chemotherapy-related complications with no mortality. Twenty-three of 30 patients in the treatment group and 17 of 36 patients in the control group had recurrences (P=.01). Patients who received adjuvant chemotherapy had a higher incidence of extrahepatic metastases (11 patients vs 5 patients; P=.03). The respective disease-free survival rates at 1, 2, and 3 years were 50%,36%, and 18% for the treatment group and 69%, 53%, and 48% for the control group (P=.04). CONCLUSION: In a group of patients who underwent curative resection of hepatocellular carcinoma, postoperative adjuvant chemotherapy using the present regimen was associated with more frequent extrahepatic recurrences and a worse outcome.