建设《凯旋》家园 复兴南多丽亚大陆——与凯旋的第一次亲密接触

凯旋(Sephiroth)自5.23开始内测以来，5000名来自全国各地的玩家有幸在第一时间登陆到神奇的南多利亚大陆．开始了全新的冒险。尽管游戏从人物、道具的设定到画面的设计都引起了广泛的争议．但无数人的趋之若骛还是充分说明了一点：这款游戏的可玩度还是蛮高的，不然就不会有这么多熬得两眼发花的法师、四肢无力的剑     

Automatic control of gas pressure in a vacuum system

This paper describes the development of a microprocessor based system to be used for the automatic setting of the gas pressure within a vacuum chamber.The requirements of the system have been presented by five modes of operation which are easily set up by thumb wheel and on/off switches on a panel. The microprocessor system automatically balances the rates of the pumping system and gas inlet to set and maintain the requested gas pressure. The gas inlet needle valve is controlled by either an ac or de motor. The use of computer software allows the system to be readily adapted for use with the commonly used needle valves, pressure gauges and pumping systems. It allows for non linear transducers and mechanical wear and additional modes of operation may be easily added when required. The system is intended for use as a subsystem of a microprocessor controlled vacuum system for laboratory or industrial use.The technique has been illustrated by controlling the pressure over the range 1–20 torr in a conventionally pumped vacuum system.     

Extracorporeal blood correction in the therapy of drug-resistant mental disorders

544 patients resistant to pharmacotherapy were treated by different methods of extracorporal hemocorrection (EH). Positive changes in mental state were achieved in more than half of the patients by means of EH without any psychopharmacologic drugs. These changes were caused by antipsychotic and antidepressive effects of EH as well as by its ability to normalize biochemical, immunological and rheological blood indices     

Anaphylaxis mediated through a humanized high affinity IgE receptor

Mast cells and basophils, which are activated by IgE and allergens through the high affinity IgE receptor (Fc epsilon RI), play a prominent role in anaphylaxis in the mouse. Mice deficient in this receptor become resistant to passive anaphylaxis. As a first step in developing an in vivo model that more closely mimics the IgE-mediated responses in man, we used a combination of transgenic and embryonic stem cell technology to generate a mouse line in which the murine Fc epsilon RI alpha-chain has been replaced with its human homologue. We demonstrate here that these mice express a tetrameric high affinity IgE receptor, in which the human alpha-chain associates with the murine beta- and gamma-chains, and that upon triggering with relevant Ag, this receptor mediates the initiation of the expected intracellular events. In addition, we show that the human alpha-chain restores an anaphylactic response to the nonresponsive alpha-deficient parental mouse line. This "humanized" mouse represents a potentially important model system, not only for studying the role of IgE in human immune responses, but also for testing potential therapeutic reagents that can interfere with responses mediated through the human Fc epsilon RI receptor.     

Measuring exhaled nitric oxide: not only a matter of how--but also why--should we do it?

We developed a method to measure the amounts of antioxidative polyphenols and ubiquinones incorporated into the liquid bilayers of liposomes to estimate their affinities for cell membranes. Results were expressed in terms of an "affinity factor", calculated by division of the amount of compound incorporated by the amount added to the liposomal solution. The results reflected dose-dependence of the biological activities of the compound found in earlier in vitro experiments with mammalian and bacterial cells.     

Integrity of systems under decentralized integral control

A decentralized controller that maintains closed loop stability, when the individual controllers fail or are taken out of service, provides fault tolerance and flexibility in operation. Recently, necessary and sufficient conditions [Gündes, Kabuli, 2001. IEEE Transactions on Automatic Control, 46(2), 296-301] for the existence of a block decentralized controller with integral action for a system to possess integrity against controller failures were proposed. In this paper, these conditions are equivalently expressed using the well-known notions of Niederlinski index (NI) and block relative gain (BRG). The alternate representation implies that under minor assumptions, the available necessary conditions based on NI and BRG are actually both necessary and sufficient. We also show that confirming the existence of a block decentralized controller with integral action such that the system has integrity is NP-hard.     

Thyroid status in patients with chronic renal failure

Serum thyroid hormone concentrations have been measured in 21 patients with chronic renal failure, treated conservatively and compared with values from 19 control subjects. Many patients had serum total T3 and T4 concentrations below the reference ranges. The concentrations of free T4 and free T3 and the free thyroxine index were significantly lower in patients with abnormal total concentrations of the thyroid hormones than in the controls. Both the free and the total concentrations of T4 correlated inversely with the degree of renal failure. The concentration of thyroxine binding globulin (TBG), fell within the reference range in each of the patients, but was significantly lower in the patient group when compared with the controls. These TBG concentrations, however, were not sufficiently decreased to explain the low total thyroid hormone concentrations found in the patients. The affinity of TBG for T4 and T3 in the patient and control groups was not significantly different. The TSH response to TRH was diminished in many of the patients, but the measurement of other pituitary hormones indicated that pituitary function was normal in these patients. The possible mechanisms responsible for the changes observed in thyroid and pituitary hormones are discussed.     

Synthesis and pharmacological evaluation of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for a novel receptor with sigma-like neuromodulatory activity

Certain novel 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes (1-phenyl-3-aminotetralins, PATs) produced stimulation (ca. 30% above basal levels) of tyrosine hydroxylase (TH) activity at 0.1 microM concentrations in rodent brain tissue. This effect on TH was blocked by the putative sigma-receptor antagonist BMY-14802, suggesting involvement of a novel neuromodulatory sigma-like receptor. Within the new phenylaminotetralin series, a correlation was found between the ability to stimulate TH and the potency to compete for binding sites labeled by (+/-)-[3H]1-phenyl-3-(N,N-dimethylamino)-6-chloro-7-hydroxy-1,2,3,4- tetrahydronaphthalene ([3H](+/-)-4). trans-Catechol analogs had low affinity for [3H]4 sites, and although they inhibited TH activity, this effect was not blocked by known sigma or dopamine antagonists. Analogs with dihydroxy substituents (catechols), as well as nitrogen substituents larger than methyl, had little affinity for [3H]4 binding sites and did not significantly affect TH activity. The pharmacology of the [3H]4 binding site is unique from that of any known sigma or dopamine receptor, thus the effects appear to be mediated by a previously uncharacterized binding site/receptor. The site has stereoselectivity for the (1R,3S)-(-)-isomer of 1-phenyl-3-(N,N-dimethylamino)-1,2,3,4-tetrahydronaphthalene; this isomer is also more active at stimulating TH. Thus, certain 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes appear to be selective probes of a novel receptor type that mediates sigma-like neuromodulatory activity and may have pharmacotherapeutic utility in conditions in which modulation of dopamine function is important.