全文获取类型
收费全文 | 879篇 |
免费 | 1篇 |
专业分类
化学工业 | 3篇 |
金属工艺 | 2篇 |
建筑科学 | 1篇 |
轻工业 | 6篇 |
冶金工业 | 865篇 |
自动化技术 | 3篇 |
出版年
2015年 | 1篇 |
2013年 | 1篇 |
2010年 | 2篇 |
2003年 | 3篇 |
1999年 | 26篇 |
1998年 | 293篇 |
1997年 | 158篇 |
1996年 | 98篇 |
1995年 | 42篇 |
1994年 | 44篇 |
1993年 | 46篇 |
1992年 | 7篇 |
1991年 | 5篇 |
1990年 | 13篇 |
1989年 | 6篇 |
1988年 | 5篇 |
1987年 | 9篇 |
1986年 | 6篇 |
1985年 | 7篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1982年 | 6篇 |
1981年 | 4篇 |
1980年 | 8篇 |
1978年 | 1篇 |
1977年 | 24篇 |
1976年 | 60篇 |
1975年 | 2篇 |
排序方式: 共有880条查询结果,搜索用时 0 毫秒
51.
52.
RA Blackwood AT Transue DM Harsh RC Brower SJ Zacharek JE Smolen RJ Hessler 《Canadian Metallurgical Quarterly》1996,59(5):663-670
Neutrophil stimulation results in the activation of a variety of phospholipases, including phospholipase A2 (PLA2), which releases arachidonic acid from the 2 position of membrane phospholipids, leaving a lysophospholipid. Because arachidonic acid is known to be a potent fusogen in vitro, we examined the effect of metabolism by PLA2 on the fusion of complex liposomes (liposomes prepared with a phospholipid composition similar to that found in neutrophil plasma membrane). We observed that PLA2 augmented the fusion of complex liposomes with each other as well as with specific granules isolated from human neutrophils, lowering the Ca2+ requirement for fusion by three orders of magnitude. Furthermore, although lysophospholipids inhibited fusion, the incorporation of arachidonic acid into liposome membranes overcame the inhibitory effects of the lysophospholipids. Thus with PLA2 and annexins we were able to obtain fusion of complex liposomes at concentrations of Ca2+ that are close to physiological. Our data suggest that the activation of PLA2 and the generation of arachidonic acid may be the major fusion-promoting event mediating neutrophil degranulation. 相似文献
53.
S Remadi K Burkhardt AT Straccia G Pizzolato W Mac Gee 《Canadian Metallurgical Quarterly》1998,194(5):371-374
OBJECTIVE: Oesophageal self-expanding metal endoprostheses (SEMS, or stents) are recognized as a safe means of palliating dysphagia caused by malignancy. Stent designs that have covered or uncovered walls are now available. The purpose of this study was to compare the outcome of use of these two designs. DESIGN: Thirty consecutive cases were reviewed. All the patients had been referred over a period of 25 months for palliation of dysphagia caused by malignant obstruction. Either a covered or an uncovered stent was placed in each patient. Palliation of dysphagia, 30 day mortality, mean survival time, and the number of endoscopic re-interventions required, were assessed. RESULTS: Uncovered Ultraflex stents were used in 14 patients, and Schneider Wallstents were used in 16 patients. Dysphagia improved by one grade or more in 69% of patients. The 30 day mortality was 27%, with an overall mean survival time of 99 days. There was no significant difference between the two groups for these three parameters. Ten patients needed a total of 28 repeat endoscopic procedures to maintain stent patency, with overall rates for each group of 1.64 procedures per patient, for uncovered stents, compared with 0.31 for covered stents (significant at the P < 0.05 level). The number of repeat procedures increased with survival time. CONCLUSION: The use of covered self-expanding metal oesophageal endoprostheses is associated with a significant reduction in the need for endoscopic reintervention after stent placement. 相似文献
54.
J Kelly R Wolin M Connolly A Afonso L James P Kirshmeier WR Bishop AT McPhail 《Canadian Metallurgical Quarterly》1998,6(6):673-686
Blocking farnesylation of oncogenic Ras proteins is a mechanism based therapeutic approach that is of current interest for the development of antitumor agents to treat ras associated tumors. As part of a SAR study on the lead farnesyl protein transferase (FPT) inhibitor I, we report here the synthesis of novel geometric isomers II and III and the FPT inhibition activity of their N-acyl and N-sulfonamido derivatives 15-65. The N-acyl derivatives are markedly less active than the lead inhibitor I thereby demonstrating that the spatial location of the N-acyl group in I is critical for binding of the compound to FPT. In contrast to I, the N-sulfonamido-II series is a novel lead of non-sulfhydryl, nonpeptidic compounds that are dual FPT/GGPT inhibitors. In light of recent reports on the alternative prenylation of N- and K-Ras, dual FPT/GGPT inhibitors may be required to control cell proliferation in tumors containing activated Ras. 相似文献
55.
56.
57.
The model proposed in this paper presents a broad range of factors to predict individual human work output. The predictors include aerobic capacity, body size, motivation, work pattern, social environment and social network, caloric intake, drug and alcohol use, stress resistance and thermoregulation. Health is a major intervening variable, and its relationship to work output is a special concern of this research. We suggest that this model may be used as a template to explain human productivity in most societies. Its universality can be subjected to rigorous testing in a range of settings from tropical upland swidden horticulturalists to urban workers in a northern industrialized country. Observations are offered on some of those testing sites and on methodological issues implicit in research of this breadth. A major pilot study of urban Chinese workers has already demonstrated the predictive power of the model in one setting. 相似文献
58.
59.
DM Sternberg AT Petrick F Gharagozloo MS Hannallah 《Canadian Metallurgical Quarterly》1997,7(5):429-431
BACKGROUND: Central Europe and the Czech Republic are specific in the prevalence of obesity which has increased by 10-40% during the last 10 years. METHODS: In the Czech republic there is 30 years of experience of a comprehensive approach to obesity treatment which includes: dietary treatment; exercise; behavioral modification; drug treatment; and bariatric surgery. Each of these approaches has its place in complex obesity management. Since 1983 bariatric surgery has been established in the Czech Republic for the treatment of morbid obesity. Vertical banded gastroplasty (VBG), gastric banding, laparoscopic nonadjustable and adjustable gastric bandings have been used over the years. Since 1993 laparoscopic gastric banding has been the only method used in our department. RESULTS: The comprehensive approach for obesity treatment in the Czech Republic has resulted in the development of obesity management and research centers, regional obesity units, obesity out-patients clinics and weight reduction clubs. The surgical treatment is a well-established part of this system and the long-term results of surgical treatment are acceptable both in terms of weight loss and complication rate. There has been no statistical difference in weight loss results following VBG and laparoscopic gastric banding, but there is a significant decrease in morbidity, and shorter hospital stay associated with laparoscopic gastric banding. CONCLUSIONS: The surgical approach in obesity treatment has an important place in the comprehensive care of obese patients. Laparoscopic gastric banding in the hands of an experienced surgeon is a method with low morbidity, short hospital stay and long-term weight loss results which are fully comparable with the results of other surgical approaches. 相似文献
60.
The volatile components of cantaloupe pericarp were analyzed during ripening by gas-liquid chromatography-mass spectrometry. Thirty-two compounds were identified from concentrates prepared by steam distillation-solvent extraction of the volatiles. Eight of the constituents including ethyl (methylthio) acetate, (Z)-6-nonenyl acetate, (Z, Z)-3,6-nonadienyl acetate, benzyl propionate, benzyl alcohol, a sesquiterpene hydrocarbon, cinnamyl acetate and an isomer of 3,4-dimethoxyacetophenone have not been identified previously. Headspace analysis of cantaloupe samples at six stages of maturity showed increases in total ethyl and acetate esters, acetaldehyde, ethyl acetate, and ethanol with maturation. Levels of these compounds remained low and relatively constant until the breaker stage and thereafter increased rapidly until the fruit was fully mature. 相似文献