Possible mechanism of hypothalamic regulation of endocrine pancreatic function in mice of the diabetic strain C57bl/KsJ

In mice hetero- and homozygotic in relation to the diabetic gene db, it was shown that the regulation of the pancreatic endocrine function by hypothalamus is mediated at least by two mechanisms: neurohumoral one connected with hormone secretion by paraventricular and supraoptical nuclei and by a neuroconductivity mechanism connected with the ventromedial nucleus and lateral hypothalamic area.     

Analysis of the structure of cardiac rhythm during treatment of auricular fibrillation with digitalis

The structure of cardiac rhythm was studied with the help of specialized computers during digitalization in 60 patients with atrial fibrillation of different etiology. The reduction of the heart contractions rate under digitalization is accompanied by certain changes in the structure of cardiac rhythm: the arrhythmic pattern of the ventricular contractions increases with a predominant growth of the number of long R--R intervals, the transitions from short intervals to longer ones become sharper, and portions of a relatively stable ventricular rhythm appear. Three main types of dynamics of the rhythm structure were distinguished on the basis of the changes in the interval R--R histogram. The described changes in the structure of cardiac rhythm are not specific, but when Digitalis drugs are used alone they can be used as additional criteria for digitalization.     

Evidence for a central substructure in a Lumbricus terrestris hemoglobin obtained with STEM low-dose and digital processing techniques

Applications of scanning transmission electron microscope (STEM) low-dose and digital image processing techniques to the annelid extracellular hemoglobin of Lumbricus terrestris have shown the existence of a central substructure. The techniques involve low-dose STEM images of less than 2 e/A2 irradiation. Many such low-dose images were then aligned in their symmetry, N-fold averaged, and summed. The central substructure appears to be supported by spokes which are connected to a surrounding hexagonal bilayer of 12 subunits. In comparison to the summed image of Nephtys hombergii hemoglobin which is known to possess a central substructure, the morphology of both central mass and spokes were very similar. This finding of a central substructure is consistent with the report of a small angle X-ray scattering study (Pilz et al., 1980, Int. J. Biol. Macromol. 2, 279-283) which predicted the possible existence of substructure in the center of the molecule.     

The cardiovascular effects of diazepam and of diazepam and pancuronium during fentanyl and oxygen anaesthesia

A study of the physiological behaviour of the synthetic compound Orthonil (alpha-chloro-beta-(3-chloro-o-tolyl)-propionitrile revealed a strong auxin activity in higher plants. Otherwise, Orthonil appeared not to be a herbicide-auxin. It is metabolized intensively in plant tissues. Among the identified metabolites, two compounds were detected which also exert a high auxin activity. It is concluded that at least a part of the apparent auxin activity of Orthonil may be due to alpha-(3-chloro-o-tolyl) acetic acid, one metabolite of Orthonil. Although Orthonil strongly stimulates elongation growth, this growth is not accompanied by a stimulated ethylene evolution as is the case with other auxins. A possible metabolic pathway of Orthonil is discussed.