全文获取类型
收费全文 | 1193篇 |
免费 | 0篇 |
国内免费 | 1篇 |
专业分类
化学工业 | 6篇 |
金属工艺 | 1篇 |
机械仪表 | 6篇 |
轻工业 | 9篇 |
无线电 | 2篇 |
一般工业技术 | 4篇 |
冶金工业 | 1158篇 |
自动化技术 | 8篇 |
出版年
2019年 | 1篇 |
2014年 | 1篇 |
2013年 | 12篇 |
2012年 | 2篇 |
2011年 | 1篇 |
2010年 | 1篇 |
2009年 | 1篇 |
2007年 | 2篇 |
2006年 | 5篇 |
2005年 | 1篇 |
2003年 | 3篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1999年 | 29篇 |
1998年 | 374篇 |
1997年 | 187篇 |
1996年 | 125篇 |
1995年 | 77篇 |
1994年 | 65篇 |
1993年 | 68篇 |
1992年 | 6篇 |
1991年 | 13篇 |
1990年 | 15篇 |
1989年 | 17篇 |
1988年 | 18篇 |
1987年 | 4篇 |
1986年 | 17篇 |
1985年 | 9篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 8篇 |
1980年 | 13篇 |
1978年 | 4篇 |
1977年 | 21篇 |
1976年 | 76篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1966年 | 1篇 |
1965年 | 1篇 |
1960年 | 1篇 |
1959年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有1194条查询结果,搜索用时 31 毫秒
11.
The microsomal enzyme glycosylphosphatidylinositol mannosyltransferase I (GPIMT-I) catalyses the transfer of a mannosyl residue from beta-mannosylphosphoryldolichol (beta-Man-P-Dol) to glucosamine-alpha(1,6)(acyl)phosphatidylinositol (GlcN-aPI) to form Man alpha(1,4)GlcN-aPI (ManGlcN-aPI), an intermediate in glycosylphosphatidylinositol (GPI) synthesis. While the transfer of [3H]mannosyl units to endogenous GlcN-aPI was not seen when membrane fractions from normal Chinese hamster ovary (CHO) K1 cells were incubated with exogenous [3H]Man-P-Dol, GPIMT-I activity could be characterized with an in vitro enzyme assay system employing membrane fractions from Lec15 or Lec35 cells. These CHO cell mutants apparently contain elevated levels of endogenous GlcN-aPI due to the inability to synthesize (Lec15) or utilize (Lec35) beta-Man-P-Dol in vivo. The presence of a saturated alpha-isoprene unit in the dolichyl moiety is required for optimal GPIMT-I activity since beta-mannosylphosphorylpolyprenol (beta-Man-P-Poly), which contains a fully unsaturated polyisoprenyl chain, was only 50% as effective as beta-[3H]Man-P-Dol as a mannosyl donor. When beta-[3H]-Man-P-Dol and alpha-[3H]Man-P-Dol were compared as substrates, GPIMT-I exhibited a strict stereospecificity for the mannolipid containing the beta-mannosyl-phosphoryl linkage. beta-[3H]Man-P-dolichols containing 11 or 19 isoprenyl units were equally effective substrates for GPIMT-I. Membrane fractions from Lec 9, a CHO mutant that apparently lacks polyprenol reductase activity and synthesizes very little beta-Man-P-Dol, but accumulates beta-Man-P-Poly, synthesized no detectable Man-GlcN-aPI when incubated with beta-[3H]Man-P-Dol in vitro. This indirect assay suggests that GlcN-aPI does not accumulate in Lec 9 cells, possibly because it is mannosylated via beta-Man-P-Poly, or perhaps the small amount of Man-P-Dol formed by the mutant in vivo.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
12.
AN Salt MM Henson SL Gewalt AW Keating JE DeMott OW Henson 《Canadian Metallurgical Quarterly》1995,88(1-2):79-86
The experiments carried out on the model of immobilization stress permit establishing the antiulcer effect of preventive introduction of sodium succinate solution, milk serum solution and solution of milk serum with sodium succinate. A decrease in the degree and number of ulcers and in the integrative indices characterizing the ulcer process after introduction of the studied drugs was accompanied by a fall of the intensity of lipid peroxidation processes. 相似文献
13.
14.
Schistosoma mansoni and S. japonicum infections in nude mice (nu/nu) were compared with infections in nu/+ heterozygotes or intact mice. Seven to 12 weeks after exposure to S. mansoni, the responses of Swiss NCR, C3H, BALB/c and C57B1/6 nude mice did not differ substantially. Nude mice of all these strains showed minute granulomas around eggs in the liver and minimal hepatic fibrosis. Microvesicular and necrotizing changes in hepatocytes were similar in all mouse strains, and S. mansoni infections were frequently lethal to nude, but not to intact mice between the seventh and ninth weeks of infection. Nude mice that survived the ninth week of infection generally lived until the 12th week. The number of eggs per mature worm pair in the tissues of S. mansoni-infected nude mice was similar to the number in intact mice, but nude mice passed fewer eggs in the feces. Nude mice that received serum from infected intact mice excreted eggs in the stool in numbers equivalent to intact mice, but continued to form minute granulomas around S. mansoni eggs. Reconstitution with fetal thymus or with splenocytes from normal or S. mansoni-infected mice partially or completely restored hepatic granuloma size, granuloma eosinophils, hepatic fibrosis, and excretion of eggs in the feces. In contrast to S. mansoni infection, S. japonicum infections in nude mice did not cause necrosis of hepatocytes or excessive mortality, and S. japonicum eggs were passed in the feces in numbers equivalent to those passed by infected intact mice. 相似文献
15.
TG Mackay D Georgiadis DG Grosset AW Kelman KR Lees DJ Wheatley 《Canadian Metallurgical Quarterly》1995,4(4):414-419
The application of transcranial Doppler (TCD) ultrasonography to asymptomatic prosthetic heart valve patients can result in detection of localized bursts of high intensity signals, similar to those caused by the passage of emboli. The origin of these signals is not known. In order to investigate this phenomenon in a simplified, more controllable environment, a TCD machine was used to record flow downstream from mechanical prosthetic heart valves in a mock circulatory loop. The model, which uses a saline solution seeded with silk particles (< 15 micrometers) as the circulatory fluid, recreates the principal hydrodynamic characteristics of the left heart and systemic circulation. Reproducibility of the system was established through repeated testing of a Monostrut valve. Three different mechanical valve types, (Monostrut, Medtronic Hall, St. Jude Medical) were tested over a range of simulated cardiac outputs, and the effect of valve size was investigated with four Omniscience tilting disc valves (21, 23, 25 and 29 mm). Average energy of the reflected Doppler signal was used to quantify the amount of high intensity Doppler signal, QTCD. TCD signals recorded in vitro were visually and aurally similar to those found in prosthetic heart valve patients. All valve types generated exponentially more QTCD with increasing simulated cardiac output. Differences amongst valve types were only significant at higher flow outputs, with the Monostrut valve producing the greatest QTCD. Larger valves consistently generated greater QTCD than smaller valves. In conclusion, TCD signals found in prosthetic heart valve patients can be reproduced, at least qualitatively, using a mock circulatory loop which does not incorporate the formed elements of blood.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
16.
AW Locher 《Canadian Metallurgical Quarterly》1996,25(6):465-469
The spread of human immunodeficiency virus (HIV) infection in women of childbearing age has precipitated discussion of the procreative rights of this population. Ethical principles are cited to support both sides of the argument. Implications for nursing care include the need to (1) examine one's own opinion on the issue, (b) assess the context in which the patient is making her decision, (c) share detailed information, and (d) create a supportive environment. 相似文献
17.
18.
AW Ibrahim 《Canadian Metallurgical Quarterly》1998,21(2-3):194-197
Shunting systems widely used for the treatment of hydrocephalus have been connected with certain risks and potential complications which stem from implanting a non-biological material into the human body. Several complications have been reported to arise from the insertion of ventriculo-peritoneal shunts. This short report highlights the observation that when anaerobic meningitis together with gram negative E. Coli in the CSF of a V-P shunted patient is found, bowel perforation should be assumed. Four cases developed such a complication among 643 hydrocephalic patients of various etiology over a period of ten years. 相似文献
19.
20.
O van der Heijden HC Chiu TC Park H Takahashi VA LiVolsi JI Risinger JC Barrett A Berchuck AC Evans K Behbakht AW Menzin PC Liu I Benjamin MA Morgan SA King SC Rubin J Boyd 《Canadian Metallurgical Quarterly》1998,23(4):243-247
The degree and nature of patient involvement in consultations with health professionals influences problem and needs recognition and management, and public accountability. This paper suggests a framework for understanding the scope for patient involvement in such consultations. Patients are defined as co-producers of formal health services, whose potential for involvement in consultations depends on their personal rights, responsibilities and preferences. Patients' rights in consultations are poorly defined and, in the National Health Service (NHS), not legally enforceable. The responsibilities of patients are also undefined. I suggest that these are not to deny, of their own volition, the rights of others, which in consultations necessitate mutuality of involvement through information-exchange and shared decision-making. Preferences should be met insofar as they do not militate against responsibilities and rights. 相似文献