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51.
TB Kinney 《Canadian Metallurgical Quarterly》1996,16(3):697-707
This article briefly summarizes the work of Charles Dotter, a pioneer in interventional radiology. His enthusiasm, powers of observation, innovations, and aggressive pursuit of his ideas permitted achievement of many radiologic milestones. 相似文献
52.
WW Wilkerson E Akamike WW Cheatham AY Hollis RD Collins I DeLucca PY Lam Y Ru 《Canadian Metallurgical Quarterly》1996,39(21):4299-4312
A series of N,N'-disubstituted cyclic urea 3-benzamides has been synthesized and evaluated for HIV protease inhibition and antiviral activity. Some of these benzamides have been shown to be potent inhibitors of HIV protease with Ki < 0.050 nM and IC90 < 20 nM for viral replication and, as such, may be useful in the treatment of AIDS. The synthesis and quantitative structure-activity relationship for this benzamide series will be discussed. 相似文献
53.
SJ Freedman DF Geesaman R Gilman MC Green RJ Holt HE Jackson ER Kinney R Kowalczyk C Marchand J Napolitano J Nelson DH Potterveld B Zeidman RE Segel T Tung D Beck G Boyd D Collins BW Filippone CE Jones J Jourdan RD McKeown R Milner R Walker PE Bosted Z Meziani R Minehart 《Canadian Metallurgical Quarterly》1993,48(4):1864-1878
54.
Effects of central GABAergic stimulation on cardiovascular function were evaluated in 2-kidney, 1-clip (2K1C) renovascular hypertensive rats (RVHR). Intracerebroventricular injection (icv) of GABA (100 and 200 micrograms) reduced blood pressure (BP) to a greater degree in RVHR as compared with sham-operated controls, and the greatest response was seen in RVHR 4 wk after operation (4 wk-RVHR). In addition, a decreased sensitivity of baroreflex was observed in 4 wk-RVHR, and was improved by icv GABA. Pretreatment with icv captopril (200 micrograms) only reduced BP moderately in 4 wk-RVHR, but attenuated remarkably the depressor effect of GABA. On the contrary, pretreatment with ip captopril was less effective in attenuating the depressor effect of GABA. Our results indicated that RVHR was deficient in central GABAergic inhibition on BP control, for GABAergic stimulation reduced BP to a greater degree and improves the decreased sensitivity of baroreflex in RVHR; the depressor effect of GABA is mediated, at least in part, by inhibiting brain angiotensin system. 相似文献
55.
56.
We report a case of myelodysplastic syndrome (MDS) with myelofibrosis and pulmonary tuberculosis who had marked basophilia in the peripheral blood. A clonal karyotypic abnormality characterized by trisomy 8 was demonstrated by cytogenetic analysis. By correlation of cell morphology with results of fluorescence in situ hybridization using a chromosome 8 probe, we demonstrated that the basophils were not reactive but belonged to the neoplastic MDS clone. 相似文献
57.
KG Karageuzyan ES Sekoyan AT Karagyan NR Pogosyan GG Manucharyan AE Sekoyan AY Tunyan VG Boyajyan MK Karageuzyan 《Canadian Metallurgical Quarterly》1998,63(10):1226-1232
The effect of low-energy infrared laser irradiation on the phospholipid pool, lipid peroxidation, and superoxide dismutase activity in the brain of white rats was studied in experimental ischemia, reperfusion, and acute edema. These models are characterized by oxidative stress; the contents of tri- and diphosphoinositides and sphingomyelins were lowered, whereas the levels of phosphatidylserine and phosphatidylethanolamine did not change, and the amount of phosphatidylcholine was increased. In acute brain edema, the contents of hydroperoxides and malonic dialdehyde in enzymatic and nonenzymic lipid peroxidation systems were increased in mitochondrial and microsomal fractions and the level of arachidonic acid was significantly elevated. Infrared laser irradiation contributes to the correction of the changes in the phospholipid pool; laser irradiation lowered the increased levels of hydroperoxides and malonic dialdehyde and elevated superoxide dismutase activity in the brain during ischemia, reperfusion, and acute edema of the brain. The data suggest that low-energy infrared laser irradiation has certain neuroprotective activity in various types of oxidative stress including ischemia, reperfusion, and acute edema of the brain. 相似文献
58.
Richards Ruth; Kinney Dennis K.; Lunde Inge; Benet Maria; Merzel Ann P.C. 《Canadian Metallurgical Quarterly》1988,97(3):281
Studies of creativity and affective illness typically focus on eminent individuals in specific fields. This is the first study to select subjects solely by diagnosis, and then evaluate their overall creative accomplishments. Seventeen manic-depressives, 16 cyclothymes, and 11 normal first-degree relatives were compared with 33 controls with no personal or family history of major affective disorder, cyclothymia, or schizophrenia; 15 controls were normal and 18 carried another diagnosis. Peak creativity was assessed by raters blind to subjects' diagnosis with the use of the Lifetime Creativity Scales. Orthogonal contrasts showed (a) creativity to be significantly higher among the combined index subjects (manic-depressives, cyclothymes, and normal relatives) than among controls (p?p? 相似文献
59.
60.
DB Johnson JF Engel EE Murrill PE Guire CW Barker CM Bardwell AY Shan MJ Swanson JG Stone-Heurner 《Canadian Metallurgical Quarterly》1978,91(1):138-145
The aglycone, 3-hydroxybenzo[a]pyrene, was metabolized to 3-benzo[a]pyrenyl-beta-D-glucopyranosiduronic acid in the presence of uridine 5'-diphosphoglucuronic acid and rabbit liver microsomes. The course of the biosynthetic reaction was followed by fluorimetry and reverse-phase, paired-ion high pressure liquid chromatography (HPLC). Also, the HPLC system was used to analyze for glucuronide and 3-hydroxybenzo[a]pyrene during the isolation procedure. The existence of a glucuronide of 3-hydroxybenzo[a]pyrene was determined by radiotracer and enzymic techniques, utilizing the HPLC system. Field desorption and direct inlet mass spectral techniques were used to characterize the 3-hydroxybenzo[a]pyrene glucuronide. 相似文献