银色温暖

冷冷的不锈钢闪亮的，在寒冷的冬日为它加上一点温暖的红，让周围的热情指数也随之高涨。     

古香古色

古雅的色彩、精细的制作，无论是带有朦胧美感的台灯，还是手法细腻的花鸟工笔画，都被晕染上一层薄薄的香气，持续至今。     

Correlates of gambling among youth in an inner-city emergency department.

Correlates of past year gambling were examined in a diverse sample of 1128 youth ages 14 to 18 (54.1% female, 58.0% African American) presenting to an inner-city emergency department (ED). Overall, 22.5% of the sample reported past-year gambling. Male youth were more likely to gamble than female youth, and African American youth reported higher rates of past-year gambling than non-African American youth. Significant bivariate correlates of gambling included lower academic achievement, being out of school, working more than 20 hours per week, alcohol, cigarette, and marijuana use, alcohol problems, severe dating violence, moderate and severe general violence, and carrying a weapon. When examined simultaneously, being male, African American, out of school, working for pay, alcohol and marijuana use, severe general violence, and carrying a weapon all emerged as significant correlates of past-year gambling, largest amount of money gambled, and gambling frequency. In addition, involvement in severe dating violence was associated with frequency and largest amount gambled. The results suggest that gambling is common among youth in the inner city and is associated with several risk behaviors. The inner-city ED may provide a context for screening and intervention to address multiple risk behaviors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Candida Cell-Surface-Specific Monoclonal Antibodies Protect Mice against Candida auris Invasive Infection

Candida auris is a multidrug-resistant fungal pathogen that can cause disseminated bloodstream infections with up to 60% mortality in susceptible populations. Of the three major classes of antifungal drugs, most C. auris isolates show high resistance to azoles and polyenes, with some clinical isolates showing resistance to all three drug classes. We reported in this study a novel approach to treating C. auris disseminated infections through passive transfer of monoclonal antibodies (mAbs) targeting cell surface antigens with high homology in medically important Candida species. Using an established A/J mouse model of disseminated infection that mimics human candidiasis, we showed that C3.1, a mAb that targets β-1,2-mannotriose (β-Man₃), significantly extended survival and reduced fungal burdens in target organs, compared to control mice. We also demonstrated that two peptide-specific mAbs, 6H1 and 9F2, which target hyphal wall protein 1 (Hwp1) and phosphoglycerate kinase 1 (Pgk1), respectively, also provided significantly enhanced survival and reduction of fungal burdens. Finally, we showed that passive transfer of a 6H1+9F2 cocktail induced significantly enhanced protection, compared to treatment with either mAb individually. Our data demonstrate the utility of β-Man₃- and peptide-specific mAbs as an effective alternative to antifungals against medically important Candida species including multidrug-resistant C. auris.     

Telephone versus mail interventions for maintenance of physical activity in older adults.

Although telephones and the mail are often used to promote physical activity, their ability to produce long-term maintenance is unclear. In this study, 140 men and women aged 50–65 years received 1 year of telephone counseling aimed at the adoption of higher (i.e., more vigorous) versus lower intensity (i.e., moderate) exercise. After 1 year, participants were rerandomized to a 2nd year of contact via (a) telephone and mail or (b) predominantly mail. Participants who were prescribed higher intensity exercise and who predominantly received mail had better exercise adherence during the maintenance year than those who received telephone and mail. Both strategies were effective in promoting maintenance in the lower intensity condition. Results suggest that after successful adoption of physical activity with the help of telephone counseling, less intensive interventions are successful for physical activity maintenance in older adults. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Episodic particle transport events controlling PAH and PCB cycling in Grand Traverse Bay, Lake Michigan

To evaluate the influence of episodic events on particle and hydrophobic organic contaminant (HOC) cycling in the Great Lakes, we deployed sequencing sediment traps at two locations in the western arm of Grand Traverse Bay, Lake Michigan. The traps collected integrated samples of settling particles every 2 weeks from May 1997 to September 1999. The total polycyclic aromatic hydrocarbon (t-PAH) and total polychlorinated biphenyl (t-PCB) settling fluxes from the surface waters in the southern site were significantly greater than those from the northern site. In addition, there were more frequent brief increases in the mass flux to the southern site than to the northern site. These episodic events, which occurred only 20% of the time, accounted for 65% of both the mass flux and t-PAH flux. The t-PCB flux was not influenced by these episodic events, and only 18% of the t-PCB flux occurred during these events. PAHs and PCBs appear to be tracing different types of particles in the water column. Several large mass flux events characteristic of seiches were observed simultaneously in the benthic nepheloid layer (BNL) at both the northern and the southern sites. The particles settling as a result of these resuspension events had lower t-PCB and t-PAH concentrations than particles settling at other times. This suggests that the material settling into the traps on the high mass flux days is composed of a mixture of the less contaminated underlying resuspended sediment and the "regular" contaminant-rich particles settling into the BNL.     

Tracing atmospheric nitrate deposition in a complex semiarid ecosystem using delta17O

The isotopic composition of nitrate collected from aerosols, fog, and precipitation was measured and found to have a large 17O anomaly with delta17O values ranging from 20 percent per thousand to 30% percent per thousand (delta17O = delta17O - 0.52(delta18O)). This 17O anomaly was used to trace atmospheric deposition of nitrate to a semiarid ecosystem in southern California. We demonstrate that the delta17O signal is a conserved tracer of atmospheric nitrate deposition and is a more robust indicator of N deposition relative to standard delta18O techniques. The data indicate that a substantial portion of nitrate found in the local soil, stream, and groundwater is of atmospheric origin and does not undergo biologic processing before being exported from the system.     

Towards Molecular Understanding of the Functional Role of UbiJ-UbiK2 Complex in Ubiquinone Biosynthesis by Multiscale Molecular Modelling Studies

Ubiquinone (UQ) is a polyisoprenoid lipid found in the membranes of bacteria and eukaryotes. UQ has important roles, notably in respiratory metabolisms which sustain cellular bioenergetics. Most steps of UQ biosynthesis take place in the cytosol of E. coli within a multiprotein complex called the Ubi metabolon, that contains five enzymes and two accessory proteins, UbiJ and UbiK. The SCP2 domain of UbiJ was proposed to bind the hydrophobic polyisoprenoid tail of UQ biosynthetic intermediates in the Ubi metabolon. How the newly synthesised UQ might be released in the membrane is currently unknown. In this paper, we focused on better understanding the role of the UbiJ-UbiK₂ heterotrimer forming part of the metabolon. Given the difficulties to gain functional insights using biophysical techniques, we applied a multiscale molecular modelling approach to study the UbiJ-UbiK₂ heterotrimer. Our data show that UbiJ-UbiK₂ interacts closely with the membrane and suggests possible pathways to enable the release of UQ into the membrane. This study highlights the UbiJ-UbiK₂ complex as the likely interface between the membrane and the enzymes of the Ubi metabolon and supports that the heterotrimer is key to the biosynthesis of UQ₈ and its release into the membrane of E. coli.