Three-Dimensional Passive Earth Pressures by Kinematical Approach

The 3D passive earth pressure problem is investigated by the upper-bound method in limit analysis. Three kinematically admissible failure mechanisms referred to as M1, Mn, and Mnt are considered for the calculation schemes. The M1 mechanism is an extension into three dimensions of the classical 2D Coulomb mechanism. The Mn mechanism is a generalization of the M1 mechanism and is composed of a sequence of rigid blocks. Finally, the Mnt mechanism is a more elaborate mechanism in which the final block of the Mn mechanism is truncated by two portions of right circular cones. The lowest upper-bound solutions given by the present analysis are compared with other authors' results and presented in a form of design tables relating the geometrical parameters, soil properties, and the 3D passive earth pressure coefficients.     

Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis

Thymosin β4 (Tβ4) was extracted forty years agofrom calf thymus. Since then, it has been identified as a G-actin binding protein involved in blood clotting, tissue regeneration, angiogenesis, and anti-inflammatory processes. Tβ4 has also been implicated in tumor metastasis and neurodegeneration. However, the precise roles and mechanism(s) of action of Tβ4 in these processes remain largely unknown, with the binding of the G-actin protein being insufficient to explain these multi-actions. Here we identify for the first time the important role of Tβ4 mechanism in ferroptosis, an iron-dependent form of cell death, which leads to neurodegeneration and somehow protects cancer cells against cell death. Specifically, we demonstrate four iron²⁺ and iron³⁺ binding regions along the peptide and show that the presence of Tβ4 in cell growing medium inhibits erastin and glutamate-induced ferroptosis in the macrophage cell line. Moreover, Tβ4 increases the expression of oxidative stress-related genes, namely BAX, hem oxygenase-1, heat shock protein 70 and thioredoxin reductase 1, which are downregulated during ferroptosis. We state the hypothesis that Tβ4 is an endogenous iron chelator and take part in iron homeostasis in the ferroptosis process. We discuss the literature data of parallel involvement of Tβ4 and ferroptosis in different human pathologies, mainly cancer and neurodegeneration. Our findings confronted with literature data show that controlled Tβ4 release could command on/off switching of ferroptosis and may provide novel therapeutic opportunities in cancer and tissue degeneration pathologies.     

Effect of Net Charge on DNA-Binding,Protein-Binding and Anticancer Properties of Copper(I) Phosphine-Diimine Complexes

Journal of Inorganic and Organometallic Polymers and Materials - The syntheses of [Cu(PPh3)2(L)]NO3 and [Cu(PPh3)2(L-SO3Na)]NO3 were achieved through the reaction of Cu(PPh3)2NO3 and equimolar...     

Effect of filler and void content on mechanical properties of pultruded composite materials under shear loading

This paper presents the results of an analytical investigation aimed at examining the mechanical behavior of fiber‐reinforced polymer matrix materials containing nonhomogeneous constituents such as fine clay fillers under shear loading. Analytical formulae that account for the presence of inhomogeneities in the matrix materials were developed for estimating the extensional and in‐plane shear moduli and Poisson's ratio. The analytical results were compared with the properties obtained from experiments. For the experiments, the pultruded composites containing clay fillers and voids as well as glass fiber and vinylester resin were selected, analyzed, and tested under shear loading. The effects of presence of constituents on the mechanical properties of matrix materials were also investigated based on the obtained volume fraction of their constituents. POLYM. COMPOS., 26:181–192, 2005. © 2005 Society of Plastics Engineers     

Research-based practice: reducing restraints in an acute care setting--phase I

The purpose of this research utilization project was to select and implement a research-based Restraint Education Program for reducing the use of restraints in an acute care setting by changing the perception of the restraint coordinators about restraints in the direction of decreased importance. The Iowa Model, Research Based Practice to Promote Quality Care (Titler et al., 1994) was selected to guide the change process. A multidisciplinary team reviewed the restraint policy and procedure, new restraint products and alternative restraint methods. After a review of the literature on restraint education programs, the committee concluded that education was the key component in decreasing the use of physical restraints. The research-based Restraint Education Program developed by Drs. Strumpf and Evans was selected as the educational program. Education sessions were developed and a pilot study was conducted with the restraint coordinators. The Perceptions of Restraint Use Questionnaire (PRUQ) (Strumpf & Evans, 1988) was administered before and after the education sessions. The results of the t-test showed a decrease in the post-test mean scores on 7 of the 17 items indicating a less important perception by the staff about the use of restraints. Four items had an increase in mean scores on the post-test indicating the restraint coordinators increased their perception of the importance of physical restraints with these items. The restraint education program was presented to the nursing staff throughout the institution. Risk management and quality assurance will monitor patients restrained and evaluate the nursing staff with the PRUQ in 3 months.     

Osseointegration evaluation of laser-deposited titanium dioxide nanoparticles on commercially pure titanium dental implants

The nanotechnology field plays an important role in the improvement of dental implant surfaces. However, the different techniques used to coat these implants with nanostructured materials can differently affect cells, biomolecules and even ions at the nano scale level. The aim of this study is to evaluate and compare the structural, biomechanical and histological characterization of nano titania films produced by either modified laser or dip coating techniques on commercially pure titanium implant fixtures. Grade II commercially pure titanium rectangular samples measuring 35?×?12?×?0.25?mm length, width and thickness, respectively were coated with titania films using a modified laser deposition technique as the experimental group, while the control group was dip-coated with titania film. The crystallinity, surface roughness, histological feature, microstructures and removal torque values were investigated and compared between the groups. Compared with dip coating technique, the modified laser technique provided a higher quality thin coating film, with improved surface roughness values. For in vivo examinations, forty coated screw-designed dental implants were inserted into the tibia of 20 white New Zealand rabbits’ bone. Biomechanical and histological evaluations were performed after 2 and 4 weeks of implantation. The histological findings showed a variation in the bone response around coated implants done with different coating techniques and different healing intervals. Modified laser-coated samples revealed a significant improvement in structure, surface roughness values, bone integration and bond strength at the bone-implant interface than dip-coated samples. Thus, this technique can be an alternative for coating titanium dental implants.     

The asymmetric displacement of a rigid spheroidal inclusion embedded in a transversely isotropic medium

Summary An explicit analytical solution is presented for the problem of a rigid spheroidal inclusion embedded in bonded contact with an infinite transversely isotropic elastic medium, where the inclusion is given a constant displacement in a direction perpendicular to the axis of symmetry of the material. The displacement potential representation for the equilibrium of three-dimensional transversely isotropic bodies is used to solve the problem. The loadfeflection relationship for the spheroidal inclusion and its limiting configurations are obtained in closed form. Numerical results are presented to show the effect of both the aspect ratio of the spheroid and the anisotropy on the translational stiffness.With 5 Figures     

Effect of sintering temperature on the microstructures and mechanical properties of sodalite infiltrate all-ceramic material for dental restorations

ABSTRACT

Potassium bromide sodalite (KBr-SOD) zeolite has been developed to enhance the mechanical properties of these restorations using a direct in situ hydrothermal condition followed by the sintering process. The purpose of this study was to determine the effects of sintering temperature on the microstructures and mechanical properties of porous alumina (A) and zirconia-toughened alumina (ZTA) discs infiltrated by KBr-SOD. Hundred and twenty disc-shaped samples were sintered at various temperatures and prepared for biaxial flexural strength and Vickers microhardness tests. The results showed that sintering temperatures from 1100 to 1600°C for both A-SOD and ZTA-SOD samples has resulted in a significant improvement in the density (2.8 and 1.1%, respectively), flexural strength (257 and 254%, respectively), Vickers hardness (109 and 112%, respectively), and Weibull modulus (7.5 and 3%, respectively). The present study concludes that infiltrated SOD material sintered at 1600°C is suitable for the fabrication of all-ceramic dental prostheses with adequate mechanical properties.     

Angiotensin-I Converting Enzyme (ACE) Inhibitory and Anti-Oxidant Activities of Sea Cucumber (Actinopyga lecanora) Hydrolysates

In recent years, food protein-derived hydrolysates have received considerable attention because of their numerous health benefits. Amongst the hydrolysates, those with anti-hypertensive and anti-oxidative activities are receiving special attention as both activities can play significant roles in preventing cardiovascular diseases. The present study investigated the angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidative activities of Actinopyga lecanora (A. lecanora) hydrolysates, which had been prepared by alcalase, papain, bromelain, flavourzyme, pepsin, and trypsin under their optimum conditions. The alcalase hydrolysate showed the highest ACE inhibitory activity (69.8%) after 8 h of hydrolysis while the highest anti-oxidative activities measured by 2,2-diphenyl 1-1-picrylhydrazyl radical scavenging (DPPH) (56.00%) and ferrous ion-chelating (FIC) (59.00%) methods were exhibited after 24 h and 8 h of hydrolysis, respectively. The ACE-inhibitory and anti-oxidative activities displayed dose-dependent trends, and increased with increasing protein hydrolysate concentrations. Moreover, strong positive correlations between angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidative activities were also observed. This study indicates that A. lecanora hydrolysate can be exploited as a source of functional food owing to its anti-oxidant as well as anti-hypertension functions.