Source-detector calibration in three-dimensional Bayesian optical diffusion tomography

Optical diffusion tomography is a method for reconstructing three-dimensional optical properties from light that passes through a highly scattering medium. Computing reconstructions from such data requires the solution of a nonlinear inverse problem. The situation is further complicated by the fact that while reconstruction algorithms typically assume exact knowledge of the optical source and detector coupling coefficients, these coupling coefficients are generally not available in practical measurement systems. A new method for estimating these unknown coupling coefficients in the three-dimensional reconstruction process is described. The joint problem of coefficient estimation and three-dimensional reconstruction is formulated in a Bayesian framework, and the resulting estimates are computed by using a variation of iterative coordinate descent optimization that is adapted for this problem. Simulations show that this approach is an accurate and efficient method for simultaneous reconstruction of absorption and diffusion coefficients as well as the coupling coefficients. A simple experimental result validates the approach.     

Scanning electrochemical microscopy. 44. Imaging of horseradish peroxidase immobilized on insulating substrates

Scanning electrochemical microscopy (SECM) was used to study horseradish peroxidase (HRP) immobilized with copolymer on insulating substrates (glass slide or polycarbonate membrane filter). Two methods were used to immobilize HRP: In the first, HRP was coimmobilized by cross-linking on a glass slide with a copolymer swelled in water to form a hydrogel; in the second, the same copolymer and avidin were coimmobilized on the glass slide and biotin-labeled HRP was conjugated to the avidin of the film. SECM was then used to detect the presence of the bound enzyme by observing the feedback current in a solution of benzoquinone and hydrogen peroxide, when hydroquinone was generated at the tip. A detection limit less than 7 x 10(5) HRP molecules within a approximately 7-microm-diameter area was demonstrated.     

How to get the most out of two phosphorus chemistries. Studies on H-phosphonates

The biological importance and practical significance of phosphate esters and their analogues have been the major driving forces for research in various areas of synthetic organic phosphorus chemistry. In this Account, the authors' studies on the development of a comprehensive H-phosphonate methodology and the underlying chemistry for the preparation of biologically important phosphate esters and their analogues are briefly discussed.     

Starting low but ending high: A reversal of the anchoring effect in auctions.

Counter to the "start high, end high" effect of anchors in individual judgments and dyadic negotiations, 6 studies using a diverse set of methodologies document how and why, in the social setting of auctions, lower starting prices result in higher final prices. Three processes contribute to this effect. First, lower starting prices reduce barriers to entry, which increase traffic and generate higher final prices. Second, lower starting prices entice bidders to invest time and energy (creating sunk costs) and, consequently, escalate their commitments. Third, the traffic generated by lower starting prices can lead bidders to infer value in the item, thereby explaining previous findings that traffic begets more traffic. The authors show that barriers to entry that limit traffic (e.g., a misspelled brand name) lead to anchoring's normal assimilative effect rather than its reversal. By broadening the understanding of anchors to extended social interactions and open markets, the authors identify when and why starting prices anchor. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

WISC-III and CAS: Which Correlates Higher with Achievement for a Clinical Sample?

The relationships between Wechsler Intelligence Scale for Children-Third Edition (WISC-III) and the Cognitive Assessment System (CAS) with the Woodcock-Johnson Tests of Achievement (WJ-III) were examined for a sample of 119 children (87 males and 32 females) ages 6 to 16. The sample was comprised of children who were referred to a specialty clinic for evaluation. Participants were administered the WISC-III, the CAS, and the WJ-III, in that order. Results indicated that CAS/WJ-III correlations were consistently significantly higher than those found for the WISC-III/WJ-III. The four separate CAS scales added more variance above and beyond the four separate WISC-III scales than the WISC-III added above and beyond the CAS. In addition, the CAS Full Scale accounted for more unique variance and was a stronger predictor of WJ-III Academic Skills Cluster than the WISC-III Full Scale IQ. These results support the validity of the Planning, Attention, Simultaneous, and Successive theory as measured by the CAS in relation to the general intelligence model measured using the WISC-III for explaining variance in achievement for this clinical sample. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

The Implementation of Innovation by a Multinational Operating in Two Different Environments: A Comparative Study

The aim of the paper is to examine the innovation initiatives and processes followed by two subsidiaries of a German multinational company operating in Europe and Asia and to compare the innovativeness of their operations in these two locations. The study examined the innovation processes followed by the two subsidiary firms operating in Germany and Malaysia, the actual problems faced by them, the critical success factors involved in the implementation, and the work climates of the firms. Interestingly, it was found that both firms followed similar innovation processes. Nevertheless, different types of problems and critical success factors were applicable to both firms. The results showed that the Malaysian subsidiary faced more behavioural problems while the German subsidiary encountered more technical problems. Further, the study showed that a lack of knowledge was the common problem faced equally by both firms. The study demonstrated that the German subsidiary had better working climate compared to its counterpart in Malaysia. Finally, the German subsidiary was found to be more innovation–active than the Malaysian subsidiary as it introduced more types of innovation, interacted with more types of entity in the external environment and introduced more types of training.     

Asymptotic convergence of scheduling policies with respect to slowdown

We explore the performance of an M/GI/1 queue under various scheduling policies from the perspective of a new metric: the slowdown experienced by the largest jobs. We consider scheduling policies that bias against large jobs, towards large jobs, and those that are fair, e.g., processor-sharing (PS). We prove that as job size increases to infinity, all work conserving policies converge almost surely with respect to this metric to no more than 1/(1−ρ), where ρ denotes the load. We also find that the expected slowdown under any work conserving policy can be made arbitrarily close to that under PS, for all job sizes that are sufficiently large.     

An authorization system for digital libraries

Digital Libraries (DLs) introduce several challenging requirements with respect to the formulation, specification, and enforcement of adequate data protection policies. Unlike conventional database environments, a DL environment typically is characterized by a dynamic subject population, often making accesses from remote locations, and by an extraordinarily large amount of multimedia information, stored in a variety of formats. Moreover, in a DL environment, access policies are often specified based on subject qualifications and characteristics, rather than subject identity. Traditional authorization models are not adequate to meet access control requirements of DLs. In this paper, we present a Digital Library Authorization System (DLAS). DLAS employs a content-based authorization model, called a Digital Library Authorization Model (DLAM) which was proposed in previous work [1]. Edited by Y. Yesha. Received: 21 December 2000 / Accepted: 6 March 2002 Published online: 14 May 2002     

Automation of Chemical Reaction Kinetics and Product Distribution Studies in Pharmaceutical Development

An automated instrument was designed and constructed to facilitate the performance of pharmaceutical degradation studies. A brief theoretical background on degradation kinetics is given to rationalize the design of the instrument and representative data are provided to illustrate its successful application. This system was found to be capable of conducting multiple simultaneous isothermal and nonisothermal kinetic studies with user-defined temperature profiles, sampling periods, and data logging.