Saleh AlNadhari;Wahidah H. Al-Qahtani;Farooque Ali Bughio;Rabia Asma Memon;Muhammad Aqeel Kamran;Ömer Said Toker;Erta Dodona;Jonida Biturku;Adrian Maho;Nidal Jaradat;Gokhan Zengin;Afat O. Mammadova;Abul Kalam Azad;Aykut Güvensen;Karimou Ngamsou Abdel; 《Microscopy research and technique》2024,87(9):2204-2211

This study discusses the micro-level structural details of Cichorieae pollen sources elucidated by scanning electron microscopy (SEM) and explains their symmetry and morphometry. The in-depth knowledge from the electron ultrastructure of Asteraceae pollen has provided insights into enhanced pollen morphology, and the antimicrobial significance of species under study presents novel avenues for their natural defense mechanisms in the development of antimicrobial agents. In this research, both quantitative and qualitative features of pollen were examined. The pollen grains are prolate-spheroidal and oblate-spheroidal in shape, characterized by a maximum polar diameter of 55.6–61.0 μm and a maximum equatorial distance of 68.3–74.4 μm. SEM reveals various configurations such as echinate perforate-tectate, psilate, and echino-lophate perforate. The Cichorieae species have significant antimicrobial efficacy and are promising sources for the development of novel antimicrobial drugs with potential implications in pharmaceutical and healthcare industries. SEM analysis of Cichorieae pollens has provided remarkable insights into their unique structures, revealing diverse shapes and surface ornamentations, which can be used for accurate Asteraceae species identification.  相似文献   

    

Adrian Yong Kwang Yeow  Cecil Eng Huang Chua 《Information Systems Journal》2020,30(2):334-368

Information system (IS) procurement history is replete with poorly executed, multimillion dollar procurement decisions. Yet we barely understand what effective IS procurement should look like. IS procurement is highly challenging, as it requires the client to simultaneously select a technology and vendor. This paper explores the technology‐vendor selection process through the sensemaking perspective. Our study develops a sensemaking model for technology‐vendor selection that connects the multiple rounds of client‐vendor communicative actions with the client's sensemaking process. We show how the client reconciles fragmented and sometimes conflicting cues and information through three intertwined cycles: immediate, retrospective, and decision. Sensebreaking occurs as a separate process (and not a communicative action) when disruptive cues occur persistently and from different vendors over multiple rounds of sensemaking. We derive a set of critical factors, on the basis of the sensemaking perspective, for selecting an appropriate vendor and technical solution. These insights in turn help explain many poorly executed IS procurement decisions.  相似文献   

    

Junyi Che  Adrian Najer  Anna K. Blakney  Paul F. McKay  Mohamed Bellahcene  Charles W. Winter  Amalia Sintou  Jiaqing Tang  Timothy J. Keane  Michael D. Schneider  Robin J. Shattock  Susanne Sattler  Molly M. Stevens 《Advanced materials (Deerfield Beach, Fla.)》2020,32(48):2003598

Uncontrolled inflammation is a major pathological factor underlying a range of diseases including autoimmune conditions, cardiovascular disease, and cancer. Improving localized delivery of immunosuppressive drugs to inflamed tissue in a non-invasive manner offers significant promise to reduce severe side effects caused by systemic administration. Here, a neutrophil-mediated delivery system able to transport drug-loaded nanocarriers to inflamed tissue by exploiting the inherent ability of neutrophils to migrate to inflammatory tissue is reported. This hybrid system (neutrophils loaded with liposomes ex vivo) efficiently migrates in vitro following an inflammatory chemokine gradient. Furthermore, the triggered release of loaded liposomes and reuptake by target macrophages is studied. The migratory behavior of liposome-loaded neutrophils is confirmed in vivo by demonstrating the delivery of drug-loaded liposomes to an inflamed skeletal muscle in mice. A single low-dose injection of the hybrid system locally reduces inflammatory cytokine levels. Biodistribution of liposome-loaded neutrophils in a human-disease-relevant myocardial ischemia reperfusion injury mouse model after i.v. injection confirms the ability of injected neutrophils to carry loaded liposomes to inflammation sites. This strategy shows the potential of nanocarrier-loaded neutrophils as a universal platform to deliver anti-inflammatory drugs to promote tissue regeneration in inflammatory diseases.  相似文献   

    

Yeonsu Kim  Ben Kaczer  Devin Verreck  Alexander Grill  Doyoon Kim  Jaeick Song  Javier Diaz-Fortuny  Andrea Vici  Jongseon Park  Simon Van Beek  Marko Simicic  Erik Bury  Adrian Chasin  Dimitri Linten  Jaewoo Lee  Jungu Chun  Seongji Kim  Beumgeun Seo  Junhee Choi  Joon Hyung Shim  Kookjin Lee  Gyu-Tae Kim 《Advanced Electronic Materials》2021,7(9):2100348

Field-effect transistors (FETs), using transition metal dichalcogenides (TMD) as channels, have various types of interfaces, and their characteristics are sensitively changed in temperature and electrical stress. In this article, the effect of fast cyclic thermal stress on the performance of FETs using TMD as a channel is investigated and introduced. The Al₂O₃ passivation layer is deposited onto the TMD channel by atomic layer deposition process, and the hysteresis decreases and the direction changes from clockwise to counterclockwise. Applying cyclic thermal stress that rapidly heats and cools by 90 K in a 20 s cycle increases and decreases drain current repeatedly as charges move between the TMD channel and the interface traps. As cyclic thermal stress is applied, permanent interfacial damage occurs, resulting in increased interface trap density at the bottom and decreased hysteresis. These experimental results are also shown through technology computer-aided design simulations. In addition, series resistance and mobility attenuation factor increase due to the concentration of the conduction paths at the bottom of the channel.  相似文献   

    

Brietzke  Adrian  Pham Xuan  Rebecca  Dettmann  André  Bullinger  Angelika C. 《Forschung im Ingenieurwesen》2021,85(2):517-526

Forschung im Ingenieurwesen - The enjoyment and usage of highly automated vehicles might be reduced by motion sickness. This study addresses the influencing factors of dynamic stimulation, visual...  相似文献   

    

Slawomir Koziel  Adrian Bekasiewicz 《International Journal of Numerical Modelling》2016,29(6):1028-1035

One of the important prerequisites for efficient design optimization of microwave structures is availability of fast yet reliable replacement models (surrogates) so that multiple evaluations of the structure at hand can be executed in reasonable timeframe. Direct utilization of full‐wave electromagnetic (EM) simulations for handling optimization‐related tasks is often prohibitive. A popular approach to construction of fast surrogates is data‐driven modeling. Unfortunately, it normally requires a large number of training samples, and it is virtually infeasible for structures that exhibit highly nonlinear responses (e.g. filters or couplers). In this work, a design‐oriented modeling technique is proposed where good accuracy is achieved by careful non‐uniform design space sampling that accounts for nonlinear relationship between the operating frequency of the structure and its geometry parameters, as well as carrying out the modeling process only for selected characteristic points of the structure responses (those that determine satisfaction/violation of given design specifications). Our approach is demonstrated using a miniaturized microstrip rat‐race coupler modeled in a wide range of geometry parameters and compared to conventional data‐driven modeling using kriging interpolation. Design optimization examples are also provided. Copyright © 2016 John Wiley & Sons, Ltd.  相似文献   

    

Alexandra Tasmoc  Mihaela‐Dora Donciu  Gabriel Veisa  Ionut Nistor  Adrian Covic 《Hemodialysis international. International Symposium on Home Hemodialysis》2016,20(3):463-472

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Zongrong Wang  Shan Wang  Jifang Zeng  Xiaochen Ren  Adrian J. Y. Chee  Billy Y. S. Yiu  Wai Choi Chung  Yong Yang  Alfred C. H. Yu  Robert C. Roberts  Anderson C. O. Tsang  Kwok Wing Chow  Paddy K. L. Chan 《Small (Weinheim an der Bergstrasse, Germany)》2016,12(28):3827-3836

A pressure sensor based on irregular microhump patterns has been proposed and developed. The devices show high sensitivity and broad operating pressure regime while comparing with regular micropattern devices. Finite element analysis (FEA) is utilized to confirm the sensing mechanism and predict the performance of the pressure sensor based on the microhump structures. Silicon carbide sandpaper is employed as the mold to develop polydimethylsiloxane (PDMS) microhump patterns with various sizes. The active layer of the piezoresistive pressure sensor is developed by spin coating PEDOT:PSS on top of the patterned PDMS. The devices show an averaged sensitivity as high as 851 kPa^?1, broad operating pressure range (20 kPa), low operating power (100 nW), and fast response speed (6.7 kHz). Owing to their flexible properties, the devices are applied to human body motion sensing and radial artery pulse. These flexible high sensitivity devices show great potential in the next generation of smart sensors for robotics, real‐time health monitoring, and biomedical applications.  相似文献   

    

Adrian Bekasiewicz  Slawomir Koziel 《国际射频与微波计算机辅助工程杂志》2016,26(8):653-659

In this work, the issues of bandwidth enhancement of planar antennas and the relevance of precise and automated response control through numerical optimization have been investigated. Using an example of a planar antenna with parasitic radiator we illustrate possible effects of even minor modifications of the antenna geometry (here, applied to the ground plane) on its reflection performance. In particular, a proper handling of geometry parameters may lead to considerable broadening of the antenna bandwidth. For the sake of computational efficiency, the adjustment of geometry parameters is carried out using surrogate‐based optimization methods exploiting coarse‐discretization EM simulations as the underlying low‐fidelity antenna model. Additionally, suitably defined penalty function allows us to precisely control the maximum in‐band reflection so that sufficient margin to accommodate possible manufacturing tolerances can be achieved. The optimized designs of the two antenna structures considered in this work exhibit over 1.75 GHz (>31%) and 2.15 GHz (>38%) bandwidth, respectively, for the center frequency of 5.6 GHz. Simulation results are validated using measurements of the fabricated prototypes. Comparison with state‐of‐the‐art designs is also provided. © 2016 Wiley Periodicals, Inc. Int J RF and Microwave CAE 26:653–659, 2016.  相似文献   

    

Tomasz Charytoniuk  Klaudia Sztolsztener  Patrycja Bielawiec  Adrian Chabowski  Karolina Konstantynowicz-Nowicka  Ewa Harasim-Symbor 《International journal of molecular sciences》2022,23(4)

It is known that metabolic disturbances, including obesity, predispose to an increased incidence of cardiovascular diseases. Elevated consumption of dietary fat results in intramyocardial accumulation of lipids and their biologically active derivatives, which can disrupt the contractile function of the heart, its metabolism, and intracellular signaling pathways. Therefore, alternative methods, such as phytocannabinoids, are being sought for the treatment of obesity-related effects. In a model of rodent obesity (seven weeks of high-fat-diet (HFD) regime), we used cannabidiol—CBD therapy (intraperitoneal injections for 14 days; 10 mg/kg). High-performance and gas-liquid chromatographies were applied in order to determine sphingolipids in the heart and plasma as well as Western blotting for protein expression. Two-week CBD administration significantly inhibited the de novo ceramide synthesis pathway in the heart of HFD fed rats by lowering sphinganine and sphinganine-1-phosphate contents. The above reductions were accompanied by markedly diminished expressions of myocardial serine palmitoyltransferase 1 and 2 as well as ceramide synthase 5 and 6 in the HFD group with 2-week CBD treatment. To our knowledge, this research is the first that reveals unknown effects of CBD treatment on the heart, i.e., amelioration of de novo ceramide synthesis pathway in obese rats.  相似文献