Leveraging industrial statistics in the data revolution: The Youden Memorial Address at the 63rd Annual Fall Technical Conference

We are in the midst of a “Data Revolution” that is transforming our economy. This revolution is as large and profound as other major economic shifts from the introduction of the printing press to the Industrial Revolution. In this article, we compare the development of the field of Industrial Statistics as an outgrowth of the Machine Age to the development of the field of Data Science as an outgrowth of the Information Age. It is shown how the knowledge, skills, and abilities required for “Data Scientists” have evolved to support companies as they try to differentiate themselves in the Information Age. It is discussed how the unique skills that Industrial Statisticians possess can provide a transformative advantage to Data Scientists working in the Information Age. Advice is given on how to leverage Industrial Statistics in the midst of the Data Revolution so that we ethically and responsibly implement the tools of Data Science, address important problems, and inclusively educate future generations.     

Highly Tunable Thiol-Ene Photoresins for Volumetric Additive Manufacturing

Volumetric additive manufacturing (VAM) forms complete 3D objects in a single photocuring operation without layering defects, enabling 3D printed polymer parts with mechanical properties similar to their bulk material counterparts. This study presents the first report of VAM-printed thiol-ene resins. With well-ordered molecular networks, thiol-ene chemistry accesses polymer materials with a wide range of mechanical properties, moving VAM beyond the limitations of commonly used acrylate formulations. Since free-radical thiol-ene polymerization is not inhibited by oxygen, the nonlinear threshold response required in VAM is introduced by incorporating 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) as a radical scavenger. Tuning of the reaction kinetics is accomplished by balancing inhibitor and initiator content. Coupling this with quantitative measurements of the absorbed volumetric optical dose allows control of polymer conversion and gelation during printing. Importantly, this work thereby establishes the first comprehensive framework for spatial–temporal control over volumetric energy distribution, demonstrating structures 3D printed in thiol-ene resin by means of tomographic volumetric VAM. Mechanical characterization of this thiol-ene system, with varied ratios of isocyanurate and triethylene glycol monomers, reveals highly tunable mechanical response far more versatile than identical acrylate-based resins. This broadens the range of materials and properties available for VAM, taking another step toward high-performance printed polymers.     

Rice field geochemistry and hydrology: an explanation for why groundwater irrigated fields in Bangladesh are net sinks of arsenic from groundwater

Irrigation of rice fields in Bangladesh with arsenic-contaminated groundwater transfers tens of cubic kilometers of water and thousands of tons of arsenic from aquifers to rice fields each year. Here we combine observations of infiltration patterns with measurements of porewater chemical composition from our field site in Munshiganj Bangladesh to characterize the mobility of arsenic in soils beneath rice fields. We find that very little arsenic delivered by irrigation returns to the aquifer, and that recharging water mobilizes little, if any, arsenic from rice field subsoils. Arsenic from irrigation water is deposited on surface soils and sequestered along flow paths that pass through bunds, the raised soil boundaries around fields. Additionally, timing of flow into bunds limits the transport of biologically available organic carbon from rice fields into the subsurface where it could stimulate reduction processes that mobilize arsenic from soils and sediments. Together, these results explain why groundwater irrigated rice fields act as net sinks of arsenic from groundwater.     

Cross-Omics Analysis of Fenugreek Supplementation Reveals Beneficial Effects Are Caused by Gut Microbiome Changes Not Mammalian Host Physiology

Herbal remedies are increasing in popularity as treatments for metabolic conditions such as obesity and Type 2 Diabetes. One potential therapeutic option is fenugreek seeds (Trigonella foenum-graecum), which have been used for treating high cholesterol and Type 2 diabetes. A proposed mechanism for these benefits is through alterations in the microbiome, which impact mammalian host metabolic function. This study used untargeted metabolomics to investigate the fenugreek-induced alterations in the intestinal, liver, and serum profiles of mice fed either a 60% high-fat or low-fat control diet each with or without fenugreek supplementation (2% w/w) for 14 weeks. Metagenomic analyses of intestinal contents found significant alterations in the relative composition of the gut microbiome resulting from fenugreek supplementation. Specifically, Verrucomicrobia, a phylum containing beneficial bacteria which are correlated with health benefits, increased in relative abundance with fenugreek. Metabolomics partial least squares discriminant analysis revealed substantial fenugreek-induced changes in the large intestines. However, it was observed that while the magnitude of changes was less, significant modifications were present in the liver tissues resulting from fenugreek supplementation. Further analyses revealed metabolic processes affected by fenugreek and showed broad ranging impacts in multiple pathways, including carnitine biosynthesis, cholesterol and bile acid metabolism, and arginine biosynthesis. These pathways may play important roles in the beneficial effects of fenugreek.     

Eco-driving: the role of feedback in reducing emissions from everyday driving behaviours

Eco-driving has been proposed as an approach to significantly reduce greenhouse gas emissions arising from personal automobile use. Eco-driving is the adoption of a measured driving style, minimising unnecessary breaking and aggressive acceleration. Eco-driving can be seen as a low cost and immediate approach to emission reduction as it involves the modification of drivers’ behaviours as opposed to the development and implementation of newer, more efficient technology. Despite the proposed benefits of eco-driving, numerous challenges are faced in order to encourage the adoption of these behaviours and maintain them long term. This narrative review presents the concept of eco-driving, with a focus on the long-term maintenance of these behaviours, including training programmes and feedback devices. It is clear within current literature that, despite the economic and environmental benefits of adopting eco-driving, drivers require feedback on their actions in order to promote long-term, behavioural, change.     

Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic Subepithelial PDGFRα+ Cells Is a New Marker for Inflammatory Bowel Disease

Metalloendopeptidase ADAM-Like Decysin 1 (ADAMDEC1) is an anti-inflammatory peptidase that is almost exclusively expressed in the gastrointestinal (GI) tract. We have recently found abundant and selective expression of Adamdec1 in colonic mucosal PDGFRα⁺ cells. However, the cellular origin for this gene expression is controversial as it is also known to be expressed in intestinal macrophages. We found that Adamdec1 mRNAs were selectively expressed in colonic mucosal subepithelial PDGFRα⁺ cells. ADAMDEC1 protein was mainly released from PDGFRα⁺ cells and accumulated in the mucosal layer lamina propria space near the epithelial basement membrane. PDGFRα⁺ cells significantly overexpressed Adamdec1 mRNAs and protein in DSS-induced colitis mice. Adamdec1 was predominantly expressed in CD45⁻ PDGFRα⁺ cells in DSS-induced colitis mice, with only minimal expression in CD45⁺ CD64⁺ macrophages. Additionally, overexpression of both ADAMDEC1 mRNA and protein was consistently observed in PDGFRα⁺ cells, but not in CD64⁺ macrophages found in human colonic mucosal tissue affected by Crohn’s disease. In summary, PDGFRα⁺ cells selectively express ADAMDEC1, which is localized to the colon mucosa layer. ADAMDEC1 expression significantly increases in DSS-induced colitis affected mice and Crohn’s disease affected human tissue, suggesting that this gene can serve as a diagnostic and/or therapeutic target for intestinal inflammation and Crohn’s disease.