挖掘回归类的混合模型的可识别性

复杂海量数据往往表现为多种结构特征的混合体，回归类混合模型就是对这种混合体的一个描述．该文基于统计学的有限混合分布理论和可识别性的相关结果，针对回归变量的三种情形：(1)解释变量固定，(2)解释变量随机，(3)解释变量固定且类别参数指定，分别讨论挖掘一般回归类的混合模型的可识别性问题，并给出同族回归类混合模型可识别的相应充分条件．这些条件的一个共同特点是它们都与一类特别的解释变量集合有关，而该类集合是由同族的回归函数与回归参数唯一确定的，其元素使不同的回归参数对应回归函数的相同值．特别地，当回归函数线性时，这类集合就是解释变量空间中的超平面．     

Global annealing genetic algorithm and its convergence analysis

A new selection mechanism termed global annealing selection (GAnS) is proposed for the genetic algorithm. It is proved that the GAnS genetic algorithm converges to the global optimums if and only if the parents are allowed to compete for reproduction, and that the variance of population's fitness can be used as a natural stopping criterion. Numerical simulations show that the new algorithm has stronger ability to escape from local maximum and converges more rapidly than canonical genetic algorithm.     

MicroRNA-155 Mediates Augmented CD40 Expression in Bone Marrow Derived Plasmacytoid Dendritic Cells in Symptomatic Lupus-Prone NZB/W F1 Mice

Systemic lupus erythematosus (SLE) is a chronic multi-organ autoimmune disease characterized by hyperactivated immune responses to self-antigens and persistent systemic inflammation. Previously, we reported abnormalities in circulating and bone marrow (BM)-derived plasmacytoid dendritic cells (pDCs) from SLE patients. Here, we aim to seek for potential regulators that mediate functional aberrations of pDCs in SLE. BM-derived pDCs from NZB/W F1 mice before and after the disease onset were compared for toll-like receptor (TLR) induced responses and microRNA profile changes. While pDCs derived from symptomatic mice were phenotypically comparable to pre-symptomatic ones, functionally they exhibited hypersensitivity to TLR7 but not TLR9 stimulation, as represented by the elevated upregulation of CD40, CD86 and MHC class II molecules upon R837 stimulation. Upregulated induction of miR-155 in symptomatic pDCs following TLR7 stimulation was observed. Transfection of miR-155 mimics in pre-symptomatic pDCs induced an augmented expression of Cd40, which is consistent with the increased CD40 expression in symptomatic pDCs. Overall, our results provide evidence for miR-155-mediated regulation in pDC functional abnormalities in SLE. Findings from this study contribute to a better understanding of SLE pathogenesis and ignite future interests in evaluating the molecular regulation in autoimmunity.     

Virtual Interpersonal Touch: Expressing and Recognizing Emotions Through Haptic Devices

ABSTRACT

This article examines the phenomenon of Virtual Interpersonal Touch (VIT), people touching one another via force-feedback haptic devices. As collaborative virtual environments become utilized more effectively, it is only natural that interactants will have the ability to touch one another. In the work presented here, we used relatively basic devices to begin to explore the expression of emotion through VIT. In Experiment 1, participants utilized a 2 DOF force-feedback joystick to express seven emotions. We examined various dimensions of the forces generated and subjective ratings of the difficulty of expressing those emotions. In Experiment 2, a separate group of participants attempted to recognize the recordings of emotions generated in Experiment 1. In Experiment 3, pairs of participants attempted to communicate the seven emotions using physical handshakes. Results indicated that humans were above chance when recognizing emotions via VIT but not as accurate as people expressing emotions through nonmediated handshakes. We discuss a theoretical framework for understanding emotions expressed through touch as well as the implications of the current findings for the utilization of VIT in human-computer interaction.     

An experimental investigation on the effects of exponential window and impact force level on harmonic reduction in impact-synchronous modal analysis

A novel method called Impact-synchronous modal analysis (ISMA) was proposed previously which allows modal testing to be performed during operation. This technique focuses on signal processing of the upstream data to provide cleaner Frequency response function (FRF) estimation prior to modal extraction. Two important parameters, i.e., windowing function and impact force level were identified and their effect on the effectiveness of this technique were experimentally investigated. When performing modal testing during running condition, the cyclic loads signals are dominant in the measured response for the entire time history. Exponential window is effectively in minimizing leakage and attenuating signals of non-synchronous running speed, its harmonics and noises to zero at the end of each time record window block. Besides, with the information of the calculated cyclic force, suitable amount of impact force to be applied on the system could be decided prior to performing ISMA. Maximum allowable impact force could be determined from nonlinearity test using coherence function. By applying higher impact forces than the cyclic loads along with an ideal decay rate in ISMA, harmonic reduction is significantly achieved in FRF estimation. Subsequently, the dynamic characteristics of the system are successfully extracted from a cleaner FRF and the results obtained are comparable with Experimental modal analysis (EMA).     

Bioactive components,ABTS radical scavenging capacity and physical stability of orange,yellow and purple sweet potato (Ipomoea batatas) powder processed by convection‐ or vacuum‐drying methods

This study aims to investigate the antioxidant properties and physical stability of convection‐ or vacuum‐dried orange, yellow and purple sweet potato (Ipomoea batatas) powder upon room temperature storage at different relative humidity (RH) of 33%, 43%, 54% and 75% for 25 days. Both convection and vacuum‐dried samples had lower total phenolic content (TPC), anthocyanin content and antioxidant activity compared to the fresh samples. Vacuum‐dried powder retained higher antioxidant activity than convection‐dried powder. Storage of the powder at high RH of 75% resulted in apparent clump formation, which was likely attributed to the decrease of glass transition temperature (T_g). In general, purple sweet potato powder contained the highest TPC (255.0 mg GAE 100 g DW^?1) and antioxidant activity (1924.0 μmol TEAC 100 g DW^?1), while orange powder had the highest beta‐carotene content (127.2 mg 100 g DW^?1). Vacuum‐dried sweet potato powder, which has relatively higher antioxidant activity, could be a potential functional ingredient or natural colourant for the food industry.     

Displacement bound of beam‐column with time‐dependent boundary constraints

Abstract

A simplified explicit formula for the displacement bounds of the beam‐column subjected to time‐dependent boundary constraints is proposed. The formula is derived by means of removing time dependence from the boundary conditions. The proposed bounds provide a quick estimation of the displacements for problems with complex loading conditions.     

A framework for identification and representation of client requirements in the briefing process

The briefing process is critical to the successful delivery of construction projects. Although a number of briefing guides have been developed, attempting to address the problems of briefing, they are often criticized as being too general and implicit. This paper describes a structured framework for identifying and representing client requirements (CRs) in the briefing process. It integrates the value management (VM) methodology with function analysis system technique (FAST) and functional performance specification (FPS) to enable the client organization and project team to systematically identify, clarify and clearly represent CRs in the briefing process. It comprises four interrelated phases: preparation, information, analysis and evaluation. This paper starts with a critical review of previous work in briefing and function analysis, followed by an introduction to the research methodology and detailed illustration of the proposed framework. The use of this framework can facilitate and lead to systematic identification and clarification of client requirements and the formation of a more precise and explicit representation of these requirements. The limitations of the approach are also discussed in the paper.