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41.
42.
Evgeny Grigoriev Anastasia V. Ponasenko Anna V. Sinitskaya Artem A. Ivkin Roman A. Kornelyuk 《International journal of molecular sciences》2022,23(23)
Assess the level of mitochondrial DNA depending on the presence of multiple organ failure in patients after heart surgery. The study included 60 patients who underwent surgical treatment of valvular heart disease using cardiopulmonary bypass. Uncomplicated patients were included in the 1st group (n = 30), patients with complications and multiple organ failure (MOF) were included in the 2nd group (n = 30). Serum mtDNA levels were determined by quantitative real-time polymerase chain reaction with fluorescent dyes. Mitochondrial DNA gene expression did not differ between group before surgery. Immediately after the intervention, cytochrome B gene expression was higher in the group with MOF, and it remained high during entire follow-up period. A similar trend was observed in cytochrome oxidase gene expression. Increased NADH levels of gene expressions during the first postoperative day were noted in both groups, the expression showed tendency to increase on the third postoperative day. mtDNA gene expression in the “MOF present” group remained at a higher level compared with the group without complications. A positive correlation was reveled between the severity of MOF according to SOFA score and the level of mtDNA (r = 0.45; p = 0.028) for the end-point “First day”. The ROC analysis showed that mtDNA circulating in plasma (AUC = 0.605) can be a predictor of MOF development. The level of mtDNA significantly increases in case of MOF, irrespective of its cause. (2) The expression of mtDNA genes correlates with the level of MOF severity on the SOFA score. 相似文献
43.
Artem Chesalkin Moldrik Petr Mišák Stanislav Averina J. M. Menshikov V. V. 《Theoretical Foundations of Chemical Engineering》2021,55(1):198-205
Theoretical Foundations of Chemical Engineering - Hydrogen is a modern energy carrier, but storage and transportation to the end consumer still stay a weak point. In this work, an experimental... 相似文献
44.
B. A. Trofimov A. V. Artem’ev N. K. Gusarova A. O. Sutyrina S. F. Malysheva L. A. Oparina 《Journal of Sulfur Chemistry》2018,39(1):112-118
Elemental phosphorus (red or white) reacts with alkyl and aryl vinyl sulfides in the superbase system KOH/DMSO(H2O) at 75–120°C for 2–3?h to afford 2-alkyl(aryl)thioethylphosphinic acids in a yield of up to 31%. 相似文献
45.
Gleb Simanov Irene Dang Artem I. Fokin Ksenia Oguievetskaia Valrie Campanacci Jacqueline Cherfils Alexis M. Gautreau 《International journal of molecular sciences》2021,22(8)
During cell migration, protrusion of the leading edge is driven by the polymerization of Arp2/3-dependent branched actin networks. Migration persistence is negatively regulated by the Arp2/3 inhibitory protein Arpin. To better understand Arpin regulation in the cell, we looked for its interacting partners and identified both Tankyrase 1 and 2 (TNKS) using a yeast two-hybrid screening and coimmunoprecipitation with full-length Arpin as bait. Arpin interacts with ankyrin repeats of TNKS through a C-terminal-binding site on its acidic tail, which overlaps with the Arp2/3-binding site. Arpin was found to dissolve the liquid–liquid phase separation of TNKS upon overexpression. To uncouple the interactions of Arpin with TNKS and Arp2/3, we introduced point mutations in the Arpin tail and attempted to rescue the increased migration persistence of the Arpin knockout cells using random plasmid integration or compensating knock-ins at the ARPIN locus. Arpin mutations impairing interactions with either Arp2/3 or TNKS were insufficient to fully abolish Arpin activity. Only the mutation that affected both interactions rendered Arpin completely inactive, suggesting the existence of two independent pathways, whereby Arpin controls the migration persistence. 相似文献
46.
Boris A. Katsnelson Ivan N. Chernyshov Svetlana N. Solovyeva Ilzira A. Minigalieva Vladimir B. Gurvich Irene E. Valamina Oleg H. Makeyev Renata R. Sahautdinova Larisa I. Privalova Anastasia E. Tsaregorodtseva Artem V. Korotkov Eugene A. Shuman Vladimir G. Panov Marina P. Sutunkova 《International journal of molecular sciences》2021,22(1)
Rats were exposed to nickel oxide nano-aerosol at a concentration of 2.4 ± 0.4 µg/m3 in a “nose only” inhalation setup for 4 h at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Based on the majority of the effects assessed, this kind of exposure may be considered as close to LOAEL (lowest observed adverse effect level), or even to NOAEL (no observed adverse effect level). At the same time, the experiment revealed genotoxic and allergic effects as early as in the first weeks of exposure, suggesting that these effects may have no threshold at all. 相似文献
47.
Artem Arlazarov Mohamed Goune Olivier Bouaziz Frédéric Kegel Alain Hazotte 《Materials Science & Technology》2019,35(17):2076-2083
Cold rolled 0.1C-4.7Mn (wt-%) steel was submitted to double annealing. The holding time of second intercritical annealing at 650°C was varied between 3 min and 30?h. Tensile behavior after each treatment was measured and analysed. Microstructure characterisation was performed using field emission gun scanning electron microscope, transmission electron microscope and saturation magnetisation method. Moreover, interrupted tensile tests were done to obtain the kinetics of austenite destabilisation during straining. An important effect of soaking time on the microstructure and associate mechanical properties was revealed and analysed. Considering thermal and mechanical stability of retained austenite, the optimum combination of phases, providing the best strength-ductility balance, was found after 2?h holding.This paper is part of a Thematic Issue on Medium Manganese Steels. 相似文献
48.
The informative-capacity phenomenon of drying drops. 总被引:1,自引:0,他引:1
Tatiana A Yakhno Vladimir G Yakhno Anatoly G Sanin Olga A Sanina Artem S Pelyushenko Natalia A Egorova Igor G Terentiev Svetlana V Smetanina Olga V Korochkina Elena V Yashukova 《IEEE engineering in medicine and biology magazine》2005,24(2):96-104
This investigation shows fundamentally good prospects for the information phenomenon of drying drops in medical diagnostics. The advantages of this method include the high information capacity, the rapid result obtainment, the small invasivity, the possibility of use by individuals without special qualification, and the low cost of the device in mass production. These properties create hope that this technology, after widescale clinical tests and the development of a prototype device, can be useful for making a preliminary diagnosis and extracting a risk group for both screening examinations and home use. 相似文献
49.
O.?A.?ShilovaEmail author T.?V.?Khamova G.?G.?Panova L.?M.?Anikina A.?M.?Artem’eva D.?L.?Kornyukhin 《Glass Physics and Chemistry》2018,44(1):26-32
Silica sols obtained by acidic or alkaline hydrolysis of tetraethoxysilane in an excess of water or ethanol in the presence of a number of salts and/or acids are used to treat the surface of barley seeds. The surface state and the elemental composition of the seeds are studied before and after their treatment in silica sols. The conditions of the sol–gel synthesis of silica sols, their effect on the state and chemical composition of the seed surface, and the sowing characteristics are analyzed. The plant’s resistance to phytopathogen, the causative agent of root rot is studied. 相似文献
50.
Andreas Weu Rhea Kumar Julian F. Butscher Vincent Lami Fabian Paulus Artem A. Bakulin Yana Yaynzof 《Advanced functional materials》2020,30(5)
Despite many advances toward improving the stability of organic photovoltaic devices, environmental degradation under ambient conditions remains a challenging obstacle for future application. Particularly conventional systems employing fullerene derivatives are prone to oxidize under illumination, limiting their applicability. Here, the environmental stability of the small molecule donor DRCN5T together with the fullerene acceptor PC70BM is reported. It is found that this system exhibits exceptional device stability, mainly due to almost constant short‐circuit current. By employing ultrafast femtosecond transient absorption spectroscopy, this remarkable stability is attributed to two separate mechanisms: 1) DRCN5T exhibits high intrinsic resistance toward external factors, showing no signs of deterioration. 2) The highly sensitive PC70BM is stabilized against degradation by the presence of DRCN5T through ultrafast, long‐range energy transfer to the donor, rapidly quenching the fullerene excited states which are otherwise precursors for chemical oxidation. It is proposed that this photoprotective mechanism be utilized to improve the device stability of other systems, including nonfullerene acceptors and ternary blends. 相似文献