Water Resources Management - Diversified water supply schemes can reduce both peak demand and overall demand in the urban water supply network. Consequently, they provide benefits to both the water... 相似文献
At the chromosomal level of evolution, recombination is a major factor for genetic variations. However, recombination does not occur with equal frequency at various regions of genome. The recombination has the tendency to occur at specific region with higher frequency and with low frequency at other regions, and former regions are named as hot recombination regions whereas later are called cold regions for recombination. In this paper, we have developed supervised machine learning-based models using artificial neural network, support vector machine and Naïve Bayes for efficient and effective classification of such hot and cold recombination regions based on the nucleotide composition of sequences. All models were validated and tested using tenfold cross-validation. Furthermore, neural network model was validated using leave one out and random sampling techniques in addition to tenfold cross-validation. Moreover, models were evaluated using receiver-operating curve. Our results indicate that artificial neural network achieves the best result.
The role of nanotopography on the long‐term response of progenitor cells is explored using polycaprolactone (PCL) nanopillar and nanofiber surfaces seeded with plastic‐adherent rat multipotent mesenchymal stromal cells (MSCs). After 4 weeks in culture under normal expansion media conditions, MSCs cultured on nanofibers exhibit better adherence, increased proliferation, and maintain increasingly dense fibroblast‐like morphologies. In contrast, MSCs seeded on nanopillar surfaces display lowered adherence, reduced proliferation, and adopt highly elongated cellular morphologies. Immunofluorescent staining of MSCs on PCL nanopillars reveals the presence of two bone marker proteins, osteopontin and osteocalcin, providing evidence for surface induced differentiation into osteoblast‐like cells. Unlike the nanopillar topography, MSCs cultured on nanofiber and smooth PCL surfaces did not appear to undergo osteogenesis. Observed differences in cellular response to the PCL nanotopographies offer strategies to direct progenitor cell populations solely based upon submicron surface modifications. This study provides a foundation for future work exploring variations in PCL nanopillar topography with the goal of optimizing adherence and osteogenic response of MSCs. 相似文献
In this investigation, biogas (BG) was used as an alternative fuel in a single-cylinder, four-stroke, air-cooled, direct injection (DI) diesel engine that was operated on a dual fuel mode. Biogas was produced from a non-edible seed de-oiled cake-pongamia pinnata (Karanja), which was collected from the biodiesel industries. The BG was inducted along with the air in suction of the engine at four different flow rates varying from 0.3?kg/h to 1.2?kg/h in steps of 0.3?kg/h. The investigation results revealed that BG inducted at a flow rate of 0.9?kg/h gives better combustion characteristics of engine behaviour than those of other flows throughout the engine operation. The ignition delay (ID) and combustion duration of the engine run by dual fuel operation at a BG flow rate of 0.9?kg/h were found to be longer by about 2 °CA and 2.9 °CA, respectively, in comparison with diesel at full load. The cylinder peak pressure was found to be overall higher by about 11?bar than that of diesel at full load. 相似文献
In this article, we report Co-Co2B and Ni-Ni3B nanocomposites as catalyst for hydrogen generation from alkaline sodium borohydride. Kinetic studies of the hydrolysis of sodium borohydride with Co-Co2B and Ni-Ni3B nanocomposites reveal that the concentration of NaBH4 has no effect on the rate of hydrogen generation. Hydrolysis was found to be first order with respect to the concentration of catalyst. The catalytic activity of Co-Co2B was found to be much higher than that of Ni-Ni3B as inferred from the activation energies 35.245 KJ/mol and 55.810 kJ/mol, respectively. Co-Co2B nanocomposites were found to be more magnetic than Ni-Ni3B. These catalysts showed superior recyclability with almost the similar catalytic activities for several hydrolytic cycles supporting the principles of sustainability. Co-Co2B catalyst showed hydrogen generation rate of about 4300 mL/min/g which is comparable to most of the reported good catalysts till date. 相似文献
Lithium-ion cells are preferred in the electrical powertrain due to high-power density, compactness, and modularity. In real driving conditions, the cells undergo discharge rates as high as 4 C resulting in high heat generation affecting the performance. To obtain the maximum performance the pack construction and thermal management of cells are crucial parameters. In our work, air-cooled technique with diverse air inlet and staggered scheme with a two-channel partition approach for thermal management of the cylindrical lithium-ion cells are studied in computational fluid dynamics. The simulation model is validated with experimental results. The obtained results demonstrate that the cells in the dual-directional air inlet arrangement had low maximum temperature difference among and within the cells and required least fan work. This arrangement required least fan work to generate optimal air inlet velocity of 2 m/s for 1, 2, and 3 C and 4 m/s for 4 C discharge rates. There is a reduction of 50% and 33% fan work for 3 and 4 C discharge rates, which are the majority operating points. Also, it shows that the temperature uniformity within the cells has improved. The results of this study can used to optimize parameters for designing an enhanced thermal management system. 相似文献
Neural Computing and Applications - Heart diseases are of notable public health disquiet worldwide. Heart patients are growing speedily owing to deficient health awareness and bad consumption... 相似文献
Blending of two or more pure polymers is an effective way to produce composites with tunable properties. In this paper, we report dynamic Monte Carlo simulation results on the crystallization of crystalline/crystalline (A/B) symmetric binary polymer blend, wherein the melting temperature of A-polymer is higher than B-polymer. We study the effect of segregation strength (arises from the immiscibility between A- and B-polymers) on crystallization and morphological development. Crystallization of A-polymer precedes the crystallization of B-polymer upon cooling from a homogeneous melt. Simulation results reveal that the morphological development is controlled by the interplay between crystallization driving force (viz., attractive interaction) and de-mixing energy (viz., repulsive interaction between two polymers). With increasing segregation strength, the interface becomes more rigid and restricts the development of crystalline structures. Mean square radius of gyration shows a decreasing trend with increasing segregation strength, reflecting the increased repulsive interaction between A- and B-polymers. As a consequence, a large number of smaller size crystals form with lesser crystallinity. Isothermal crystallization reveals that the transition pathways strongly depend on segregation strength. We also observe a path-dependent crystallization behavior in isothermal crystallization: two-step (sequential) isothermal crystallization yields superior crystalline structure in both A- and B-polymers than one-step (coincident) crystallization. 相似文献