Changes in volatile composition during fruit development and ripening of ‘Alphonso’ mango

BACKGROUND: Volatile blends of five developing and five ripening stages of mango (Mangifera indica L. cv. Alphonso) were investigated along with those of flowers and leaves. Raw and ripe fruits of cv. Sabja were also used for comparison. RESULTS: A total of 55 volatiles belonging to various chemical classes such as aldehydes, alcohols, mono‐ and sesquiterpene hydrocarbons, lactones and furanones were identified. In all Alphonso tissues monoterpenes quantitatively dominated, with 57–99% contribution; in particular, (Z)‐ocimene was found in the highest amount. Ripeness was characterized by the de novo appearance of lactones and furanones in the blend of monoterpenes. Sabja was distinguished by the abundance of monoterpene hydrocarbons in the raw fruit, and that of sesquiterpene hydrocarbons and their derivatives in the ripe stage. CONCLUSION: Various stages of the Alphonso fruit during transition from flower to ripe fruit are characterized by unique volatile signatures that are distinguished from each other by the qualitative and quantitative appearance of different volatile compounds. Thus volatiles can be highly informative markers while studying the development and ripening of mango. Copyright © 2009 Society of Chemical Industry     

Solid dispersion adsorbate technique for improved dissolution and flow properties of lurasidone hydrochloride: characterization using 32 factorial design

The aim of the present study was to improve the dissolution and flow properties of lurasidone hydrochloride (LH) by solid dispersion adsorbate (SDA) technique. Solid dispersions (SDs) of LH were prepared by fusion method using Poloxamer P188. The melt dispersion was adsorbed onto the porous carrier Florite (calcium silicate). A 3² factorial design was employed to quantify the effect of two independent variables, namely ratio of carrier (Poloxamer 188) and LH in SD and ratio of adsorbent (Florite) to SD. SDA granules of LH were studied for flow properties and characterized using differential scanning calorimetry, scanning electron microscopy, and X-ray diffraction. Tablets of optimized composition of SDA granules (equivalent to 20?mg of drug) and plain tablets were prepared by direct compression method. The dissolution studies were carried out in Mcllvaine buffer (pH 3.8) as per USFDA guidelines and characterized for parameters such as percent dissolution efficiency, t₅₀, and Q₃₀. Tablets prepared from SDA granules showed almost four-fold increase in cumulative percentage drug release as compared to tablets prepared from plain LH. The value of dissolution efficiency was enhanced from 49.60% for plain tablets to 94.15% for SDA tablets. SDA granules did not show any change in drug release and X-ray diffraction pattern after storage at 40?°C/75% of RH for 3?months, which confirms that Florite prevented conversion of drug from amorphous form to crystalline form improving physical stability of the amorphous state of LH.     

Measurements of chemical warfare agent degradation products using an electrophoresis microchip with contactless conductivity detector

This paper reports on a microfluidic device for the screening of organophosphonate nerve agent degradation products. The miniaturized system relies on an efficient chip-based separation of alkyl methylphosphonic acids (breakdown products of Sarin, Soman, and VX nerve agents) followed by their sensitive contactless conductivity detection. Experimental parameters relevant to the separation and detection processes have been optimized to yield high sensitivity (with 48-86 microg L(-1) detection limits), fast response (50 s for a three alkyl methylphosphonic acid mixture), high precision (RSD = 3.8-5.0%), and good linearity (over the 0.3-100 mg L(-1) range). Applicability to natural (river) water samples is demonstrated. The new microsystem offers promise for monitoring degradation products of chemical warfare agents, with advantages of speed/warning, efficiency, portability, sample size, and cost compared to conventional ion chromatography or capillary electrophoresis systems.     

The VVERs at KudanKulam

A Nuclear Power Project is being set-up at KudanKulam in the state of Tamil Nadu, India in collaboration with the Russian Federation. The project comprises of two units each of 1000 MWe VVER type reactor. The design of the plant and supply of all the major equipment is in the scope of the Russian Federation while development of infrastructure and project construction is in Indian scope of works. The VVER (Version V-412) reactor that is under construction at KudanKulam site is an advanced PWR, which incorporates all the features of a modern PWR as per the current Russian, Western and IAEA standards. The KudanKulam site in the southern Indian state of Tamil Nadu was one among the several sites evaluated by the Site Selection Committee, which cleared KudanKulam site for setting up an installed capacity up to 6000 MWe. The design, construction and operation of the plant meets the regulatory and licensing requirements of Russian regulatory body “RTN” as also India's Atomic Energy Regulatory Board. The supply of the equipment from the Russian Federation is on schedule and the project construction work by various Indian agencies is also ahead of schedule. The two units of KudanKulam Nuclear Power Project (KKNPP) are scheduled to achieve first criticality in the year 2007–2008. The paper discusses various design features, project construction and management aspects.     

Use of the nanoindentation technique for studying microstructure/crack interactions in the fatigue of 4340 steel

The objectives of this research are to study the influence of microstructure on the fatigue crack growth behavior in 4340 steel and to explore the application of the nanoindentation technique for determining the plastic deformation zone at a fatigue crack tip. Two heat treatment conditions were chosen for the steel: annealed and quenched plus tempered. The annealed steel consists of coarse pearlite and proeutectoid ferrite, while the quenched and tempered steel consists of fine tempered martensite. Fatigue crack propagation tests were conducted on disklike compact (DCT) specimens. Subsequently, the nanoindentation technique was applied to quantitatively determine the plastic deformation zone at fatigue crack tips. The plastic deformation zone size determined by the nanoindentation test seems larger than the cyclic deformation zone calculated using the fracture mechanics equation, which involves many assumptions. The fatigue crack growth test results show that the annealed steel has a higher resistance to crack growth than the quenched and tempered steel. The fatigue crack in the annealed steel tends to grow along pearlite domain boundaries, or the cementite/ferrite interfaces within a pearlite domain. In contrast, the fatigue crack in the quenched and tempered steel tends to traverse the fine martensite laths. Consequently, the actual crack path in the annealed steel is rougher than in the quenched and tempered steel and more secondary cracks are observed in the annealed steel.     

Sponsored R&D in India: The project sponsoring pattern and main outcome of projects sponsored by major central departments/agencies

This paper examines the project sponsoring pattern and the outcome of extramural R&D with respect to the projects sponsored by country's eleven central agencies during the Seventh Five-Year Plan period. The outcome considered are: contribution of R&D support to development of R&D facilities at the recipient institutions, creation of employment through project posts, development of new technologies, quantum and quality of research publications and generation of doctoral thesis. The paper concludes that sponsored R&D has largely remained one-way flow of funds to a preferred set of institutions (as perceived by each sponsoring agency) and the outcome of the R&D have also remained unexamined by the respective funding agencies. The paper advocates development of a monitoring system which would help in enhancing the utilisation of sponsored R&D and its overall impact on science, society and economy.     

On profit considerations of a maintained system with minor repair

A maintained system is considered which can exit from the operable state to two states: failed and less productive. Profit equations are developed to study the system behaviour and a condition is derived under which the system can be profitably operated in a less productive state. A numerical example has been included to illustrate the results.     

The effect of oxide surface layers on the breakdown voltage in metal-vacuum-metal sandwiches

Correlations are explored between the observed breakdown voltages in metal-vacuum-sandwiches and the properties of the metallic electrodes which are believed to be covered by oxide layers. A linear relationship is indicated between the work function of the electrode and the breakdown voltage. This relationship may prove useful in obtaining more accurate estimates for the breakdown voltage of the vacuum dielectric itself, when it is sandwiched between a wide variety of electrode materials.     

Optimal Inspection Policy For Multistage Production Process With Alternate Inspection Plans

This paper considers a multistage production process with alternate inspection plans. At each stage a number of alternate inspection plans with different cost and reliabilities may be available. Since more reliable inspections are more costly it is essential to find out a compromise between the reliability and cost. A mathematical model is developed. Dynamic programming is used to determine at each stage that out of the available inspection plans (including the case of no inspection) which one will result in minimum s-expected total cost per item.     

Photoconductivity storage in Ga1−xAlxAs alloys at low temperatures

Intentionally undoped n-type and high purity Ga_1?xAl_xAs alloys with compositions in the range 0.19≤x≤0.78 are found to show a long life time photoconductivity effect at low temperatures (T < 80 K) when irradiated with white light filtered through a Ge filter and also when the light source is removed after photoexcitation. For the direct gap materials (0≤x≤ 0.43), it is shown that the deep level in the alloys, which controls the electrical properties of the crystals, captures and emits electrons via the first higher energy subsidiary conduction band inima L although the Γ minimum is the lowest in energy. These indirect electron transitions by the deep level, via the L minima, which is found to have an acceptor like nature, provide a natural explanation of the photoconductivity storage at low temperatures. For indirect gap materials (x > 0.43), when X minima are the lowest energy subsidiary minima, the photoconductivity storage at low temperatures is due to the double acceptor nature of the deep level.