Hepatic cholesterol metabolism in experimental nephrotic syndrome

Hypercholesterolemia is a consistent feature of the nephrotic syndrome. However, the mechanisms underlying this perturbation are unclear. In the present work, we have investigated different factors that influence hepatic cholesterol metabolism using the nephrotic rat as a model. The induction of nephrosis resulted in a severe and sustained hypercholesterolemia. However, no effect on the rate-limiting enzyme in cholesterol synthesis, 3-hydroxy-3-methylglutaryl CoA reductase, could be detected. Further, plasma lathosterol/cholesterol ratio, a measure of cholesterol synthesis, was not altered. Also, plasma levels of mevalonate, both a substrate for cholesterogenesis beyond the rate-limiting step and a marker for cholesterol synthesis, did not differ between control rats and those with established hypercholesterolemia. There was no detectable change in the expression of low density lipoprotein (LDL) receptor between the two experimental groups. We conclude that the early increase in cholesterol synthesis reported after the induction of nephrosis is not necessary for the maintenance of hypercholeserolemia. Established hypercholesterolemia of the nephrotic syndrome seems to represent a steady state in which neither enhanced hepatic cholesterol synthesis nor retarded LDL cholesterol clearance is of major importance.     

Hydrophobic polyethersulfone porous membranes for membrane distillation

Membrane distillation (MD) is a thermal, vapor-driven transportation process through micro porous hydrophobic membranes that is increasingly being applied to seawater and brine desalination processes. Two types of hydrophobic microporous polyethersulfone flat sheet membranes, namely, annealed polyethersulfone and a polyethersulfone/tetraethoxysilane (PES/TEOS) blend were prepared by a phase inversion process. The membranes were characterized and their performances were investigated using the vacuum membrane distillation of an aqueous NaCl solution. The performances of the prepared membranes were also compared with two commercially available hydrophobic membranes, polytetrafluorethylene and polyvinylidene fluoride. The influence of operational parameters such as feed temperature (25–65 °C), permeate vacuum pressure (200–800 mbar), feed flow rate (8–22 mL/s) and feed salt concentration (3000 to 35000 mg/L) on the MD permeation flux were investigated for the four membranes. The hydrophobic PES/TEOS membrane had the highest salt rejection (99.7%) and permeate flux (86 kg/m²·h) at 65 °C, with a feed of 7000 ppm and a pressure of 200 mbar.     

Adsorption separation of condensate oil from produced water using ACTF prepared of oil palm leaves by batch and fixed bed techniques

A novel method is applied to produce amorphous carbon thin film (ACTF) from oil palm leaves. The novel prepared ACTF is in the form of thin films like graphene sheets having winding surface. ACTF was characterized by different methods of characterization: FTIR, BET, SEM, EDX, TEM, and Raman. ACTF employed as an adsorbent to separate emulsified condensate oil from synthetic produced water as a treatment process before reinjection in oil reservoirs. The adsorption performance of batch and fixed bed adsorption systems were investigated. Contact time, initial concentration of condensate oil ($C_o$ = 100–2500 mg/l) and temperature were studied by batch experiments. The obtained results indicated that the adsorption capacity and the removal efficiency increased with time up to 132.77 mg condensate/g adsorbent and 66.38% respectively, within 6 h equilibrium time at 308 K. The thermodynamic adsorption experiments conducted at 288, 308 and 318 K, referring exothermic nature of the adsorption process.The performance study of fixed bed adsorption described through the breakthrough curves concept with two parameters: column bed heights (5, 10 and 15 mm) and flow rate (2.2, 5 and 8.4 ml/min). Two models (Thomas and Yoon-Nelson models) were applied to expect different parameters of fixed bed as adsorption capacity and time need for 50% breakthrough. The results exhibited that 2.2 ml /min feed flowrate and 5 mm bed height at 1000 mg/l initial oil condensate concentration were the optimum conditions for the ACTF column. The experimental breakthrough curves showed acceptable fit with the calculated breakthrough profiles obtained by Thomas model.     

Enhancement of the dissolution and permeation rates of meloxicam by formation of its freeze-dried solid dispersions in polyvinylpyrrolidone K-30

Freeze-drying (FD) and solvent evaporation (SE) were used to prepare solid dispersions (SDs) of meloxicam (MX) in polyvinylpyrrolidone K-30 (PVP). The SDs were prepared at different ratios, namely 1:1, 1:3, and 1:5 MX:PVP weight ratio. Differential scanning calorimetry (DSC), infrared absorption spectroscopy (IR), and x-ray powder diffractometry (XPD) were utilized to characterize the physicochemical properties of the SDs. Meloxicam (MX) in the solid dispersions appeared with less crystallinity form and was present in a complete amorphous form at higher PVP ratio. Dissolution rates of MX as a pure drug, physical mixtures (PMs), and SDs indicated a marked increase of the dissolution rate of MX in presence of PVP. The increase in the dissolution rate was dependent on the ratio of PVP and the method of preparation. In addition, the permeability of the drug through standard cellophane membrane and hairless mouse skin was also evaluated. The permeation rate of MX was significantly increased in the case of SDs and was dependent on the ratio of PVP. The results were primarily due to increase wettability, the solubilization of the drug by the carrier, and formation of MX amorphous form.     

Modeling and simulation of solar-powered liquid desiccant regenerator for open absorption cooling cycle

This paper presents the modeling and simulation of solar-powered desiccant regenerator used for open absorption cooling cycles. The input heat, which is the total radiation incident on an inclined surface, is evaluated via a solar radiation model in terms of the location, day of the year, and time of the day. Calcium Chloride (CaCl₂) is applied as the working desiccant in this investigation. The solar radiation model is integrated with the desiccant regenerator model to produce a more realistic simulation. A finite difference method is used to simulate the combined heat and mass transfer processes that occur in the liquid desiccant regenerator. The system of equations is solved using the Matlab-Simulink platform. The effect of the important parameters, namely the regenerator length, desiccant solution flow rate and concentration, and air flow rate, on the performance of the system is investigated. It has been found that the vapor pressure difference has a maximum value for a given regenerator length. It is also shown that for specified operating conditions, a maximum value of the coefficient of performance occurs at a given range of air and solution flow rates. Therefore, it is essential to select the design parameters for each ambient condition to maximize the coefficient of performance of the system.     

Statistical Analysis on the Cost and Duration of Public Building Projects

A probabilistic model is proposed to predict the risk effects on time and cost of public building projects. The research goal is to utilize a real history data in estimating project cost and duration. The model results can be used to adjust floats and budgets of the planning schedule before project commencement. Statistical regression models and sample tests are developed using real data of 113 public projects. The model outputs can be used by project managers in the planning phase to validate the schedule critical path time and project budget. The comparison of means analysis for project cost and time performance indicated that the sample projects tend to finish over budget and almost on schedule. Regression models were developed to model project cost and time. The regression analysis showed that the project budgeted cost and planned project duration provide a good basis for estimating the cost and duration. The regression model results were validated by estimating the prediction error in percent and through conducting out-of-sample tests. In conclusion, the models were validated at a probability of 95%, at which the proposed models predict the project cost and duration at an error margin of ±0.035% of the actual cost and time.     

Effect of mineralogical composition and kerogen content on oil shale natural floatability

Mineralogical composition is one of the important factors that affect the performance of separation processes. In the current study, two oil shale samples, from El-Nakhil and El-Bieda localities, differ in their mineralogical composition, were subjected to flotation tests. Chemical analysis, differential thermal analysis (DTA), thermo-gravimetric analysis (TGA), and microscopic examination are among the used characterization techniques. In addition, their responses for upgrading by flotation were conducted as a function of pH, solid-liquid ratio, stirring speed and different particle sizes. The characterization results indicated that the kerogen content in El-Nakhil sample was 30% while in El-Beida sample was 10%. On the other hand, the flotation results indicated that El-Bieda responses better than that of El-Nakhil in terms of the difference in kerogen % between the original sample and the concentrated ones. The difference in flotation results of two samples can be explained by the difference in kerogen morphology as well as its interaction with surrounding matrix. In El-Bieda the kerogen has a laminated structure but in El-Nakhil it appears as laminated liptinitic component, in addition to the higher carbonate content in El-Nakhil sample in comparison to higher clay content in El-Bieda sample.     

A Fully Coupled Thermomechanical Model of Friction Stir Welding(FSW) and Numerical Studies on Process Parameters of Lightweight Aluminum Alloy Joints

This paper presents a new thermomechanical model of friction stir welding which is capable of simulating the three major steps of friction stir welding(FSW) process, i.e., plunge, dwell, and travel stages. A rate-dependent Johnson–Cook constitutive model is chosen to capture elasto-plastic work deformations during FSW. Two different weld schedules(i.e., plunge rate, rotational speed, and weld speed) are validated by comparing simulated temperature profiles with experimental results. Based on this model, the influences of various welding parameters on temperatures and energy generation during the welding process are investigated. Numerical results show that maximum temperature in FSW process increases with the decrease in plunge rate, and the frictional energy increases almost linearly with respect to time for different rotational speeds. Furthermore, low rotational speeds cause inadequate temperature distribution due to low frictional and plastic dissipation energy which eventually results in weld defects. When both the weld speed and rotational speed are increased, the contribution of plastic dissipation energy increases significantly and improved weld quality can be expected.     

Effect of Celestite-Calcite Mineralogy on Their Separation by Attrition Scrubbing

Celestite ore is one of the principle economic resources of strantium element. Naturally, it contains some impurities, with the main one being the calcite mineral. In this article, the separation of celestite from calcite was conducted using attrition scrubbing based on the difference in the hardness between the two minerals. Due to the friability of calcite, it was expected to be collected in fine fraction, however, this was not the case. The observed results showed the presence of calcite in both coarse and fine fractions. A high percentage of calcite was found in the coarse fraction and decreased as the size did as well. Yet, at certain sizes its behavior was changed in that the decrease in size increased the calcite percentage. This behavior was clarified using detailed characterization of the studied sample using size analysis, x-ray diffraction, chemical analysis, and microspcopisc investigation. In addition, a detailed microscopic analysis for the products of the attrition scrubbing was conducted to explain the observed behavior.     

Inactivation of pathogenic Klebsiella pneumoniae by CuO/TiO2 nanofibers: A multifunctional nanomaterial via one-step electrospinning

The fabrication and characterization of one-dimensional CuO/TiO₂ nanofibers with high photocatalytic and antibacterial activities are presented. The CuO/TiO₂ nanofibers were prepared by electrospinning of colloid composed of titanium isopropoxide, poly(vinylpyrroliodine) (PVP) and copper nanoparticles and calcination at 700 °C in air for 1 h. The antibacterial activity was tested using Klebsiella pneumoniae as model organism by calculation of the minimum inhibitory concentration (MIC). The obtained CuO/TiO₂ nanofibers showed prominent photocatalytic activity under visible light to degrade reactive black5 and reactive orange16 dyes in aqueous solutions and effectively catalyze K. pneumoniae inactivation. The decomposition process of the cell wall and cell membrane was directly observed by TEM analysis after the exposure of the K. pneumoniae to the nanofibers. Interestingly, the introduced photocatalyst can be reused with the same photocatalytic activity. Overall, the combination of CuO and TiO₂ can be synergistic and resulted in CuO/TiO₂ composite nanofibers having superior photocatalytic and antimicrobial potential to impede K. pneumoniae growth which causes bacterium to die ultimately.